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Cover Picture Palladium-Catalyzed Enantioselective Domino Reaction for the Efficient Synthesis of Vitamin E (Angew. Chem. Int. Ed. 22005)

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Lutz F. Tietze,* Konrad M. Sommer, Julia Zinngrebe, and
Florian Stecker
A domino reaction consists of several consecutive transformations in which the
functions required for one reaction are generated in the preceding bond-formation or
fragmentation step. L. F. Tietze et al. applied this concept to the synthesis of
vitamin E described on page 257 ff. They developed an enantioselective palladiumcatalyzed process for the construction of the chiral chroman framework with 96 % ee
and concomitant introduction of part of the side chain.
Fluorination
The demand for an electrophilic fluorinating agent that is easy to handle, stable, and
highly reactive ultimately led to the development of selectfluor. C.-H. Wong and coworkers discuss the applications and reaction mechanisms of this reagent in their
Review on page 192 ff.
Organofluorine Compounds
Fluorine substitution can have a dramatic effect on the properties of organic
compounds, including pharmaceuticals and materials. Methods for the synthesis of
organofluorine compounds are reviewed by T. Hiyama and M. Shimizu on
page 214 ff.
Fullerenes
In their Communication on page 234 ff. P. A. Troshin, S. I. Troyanov et al. describe a
highly chlorinated stable fullerene consisting of a cylinder-shaped carbon cage.
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reaction, 22005, enantioselectivity, catalyzed, int, efficiency, cover, angel, synthesis, vitamins, domino, chem, palladium, picture
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