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Cover Picture Phloroglucinol Derivatives GuttiferoneG Aristoforin and Hyperforin Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed

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Cover Picture
Claudia Gey, Sergiy Kyrylenko, Lothar Hennig, Lien-Hoa D. Nguyen,
Anita Bttner, Hung D. Pham, and Athanassios Giannis*
Hippocrates
(the father of medicine) described the healing properties of St. Johns wort 2500 years
ago and prescribed it for the treatment of depression. Hyperforin, which is considered
to be responsible for this activity, also has anticancer, antibacterial, and woundhealing activity. A. Giannis et al. describe in their Communication on page 5219 ff.
that hyperforin and two related compounds are inhibitors of sirtuins SIRT1 and
SIRT2. This property could explain some of the pharmacological properties of
hyperforin.
Ansa Complexes
In their Review on page 5060 ff., I. Manners and co-workers describe the synthesis
and properties of strained metallocenophanes and related compounds, some of
which undergo insertions and ring-opening polymerization under the right
conditions.
Polyferrocenylsilanes
Numerous polyferrocenylsilane materials with exceptional physical properties and
functions are accessible through ring-opening polymerization, as M. Rehahn and V.
Bellas summarize in their Review on page 5082 ff.
Fluorinated Carbocycles
Reversal is the trump card when the traditional approach to fluorinated ring
systems by Diels–Alder reaction and subsequent fluorination fails. In their
Communication on page 5105 ff, V. Gouverneur et al. show how inverting the two
steps solves selectivity issues.
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human, derivatives, guttiferoneg, int, phloroglucinol, cover, angel, hyperforin, sirt2, aristoforin, chem, inhibitors, sirt1, picture, sirtuins
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