Cover Picture Single DNA Rotaxanes of a Transmembrane Pore Protein (Angew. Chem. Int. Ed. 232004)код для вставкиСкачать
Cover Picture Jorge Snchez-Quesada, Alan Saghatelian, Stephen Cheley, Hagan Bayley, and M. Reza Ghadiri* A single rotaxane structure created by threading and capturing a DNA–poly(ethylene glycol) (DNA–PEG) strand inside an a-hemolysin (a-HL) transmembrane pore protein is described by M. R. Ghadiri and co-workers on page 3063 ff. The DNA–aHL rotaxanes exhibit a reversible two-state switching capacity that depends on the applied transmembrane potential, the orientation, and the method of threading and capture used. Functional rotaxanes might provide a means for critically assessing the feasibility of the pore-mediated single-molecule DNA sequencing hypothesis.