Cover Picture Solid-Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin3147A2 (Angew. Chem. Int. Ed. 492008)код для вставкиСкачать
D 3461 International Edition www.angewandte.org 2008–47/49 Azadirachtin S. V. Ley et al. Ernest Rutherford J. M. Thomas Ribosomal Peptide Synthesis B. S. Moore Cortistatin A C. F. Nising and S. Bräse ACIEFS 47 (49) 9357–9574 (2008) · ISSN 1433–7851 · Vol. 47 · No. 49 Cover Picture Vijaya R. Pattabiraman, Shaun M. K. McKinnie, and John C. Vederas* A two-peptide lantibiotic is active against certain pathogenic bacteria in nanomolar concentrations. In their Communication on page 9472 ff., J. C. Vederas and coworkers describe the first solid-supported synthesis of lacticin 3147, the bis(desmethyl) analogue of lacticin A2. This compound shows potent synergistic antimicrobial activity in the presence of lacticin A1. Other lantibiotics can be prepared for the study of structure–activity relationships by using this strategy. Annie Tykwinski is thanked for the cover graphic design. History of Science The physicist Ernest Rutherford was awarded the Nobel Prize in Chemisty in 1908. To mark this centennial, Sir J. M. Thomas looks back on the life and achievements of this brilliant scientist in his Essay on page 9392 ff. Natural Product Synthesis The natural product azadirachtin, which was first isolated in 1968 from the neem tree, has been the focus of intense research efforts for decades. S. V. Ley and co-workers indicate in their Review on page 9402 ff. which routes fell by the wayside and which paths finally led to success. Hypervalent S S Bonds N. Kano, T. Kawashima, and co-workers describe the synthesis, characterization, and reactivity of a stable hypervalent SIV SII bond in a sulfurane in their Communication on page 9430 ff.