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Cover Picture Total Synthesis and Antitumor Activity of ZK-EPO The First Fully Synthetic Epothilone in Clinical Development (Angew. Chem. Int. Ed. 472006)

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Cover Picture
Ulrich Klar,* Bernd Buchmann, Wolfgang Schwede, Werner Skuballa,
Jens Hoffmann, and Rosemarie B. Lichtner
Nature is a brilliant architect for the design of compounds with interesting biological
functions. Epothilone B (top), a metabolite of myxobacteria (fruiting body in
background), served as the lead structure for the development of an anticancer drug
candidate. Optimization efforts led to ZK-EPO (bottom) as a candidate for clinical
development. ZK-EPO has an improved therapeutic window and is not recognized by
multidrug-resistance efflux pumps. Its total synthesis starting from simple
compounds (blue) is described by U. Klar et al. on page 7942 ff.
Anion Coordination
Crystallographic data are used to categorize the coordination modes of anions with
amide-based ligands according to coordination number and geometry. This
classification is explained by K. Bowman-James and co-workers in the Minireview on
page 7882 ff.
Gold Catalysis
Gold is equally effective as a heterogeneous and a homogeneous catalyst. An account
of the chemistry of gold catalysis, with particular emphasis on redox reactions and
nucleophilic additions, is found in the Review by A. S. K. Hashmi and G. J. Hutchings
on page 7896 ff.
Chiral Microporous Materials
In their Communication on page 7938 ff., J. Rocha et al. describe the discrimination
of enantiomeric domains in microporous lanthanide silicates with unpolarized light
and in the absence of external fields. This phenomenon could be important in the
interaction of light with condensed matter.
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development, epo, epothilone, synthetic, int, cover, angel, synthesis, tota, first, chem, clinical, 472006, activity, full, picture, antitumor
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