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Cover Picture Tumor-Associated MUC1 Tandem-Repeat Glycopeptide Microarrays to Evaluate SerumЦ and MonoclonalЦAntibody Specificity (Angew. Chem. Int. Ed. 442009)

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D 3461
www.angewandte.org
2009–48/44
Lithium-Ammonia Solutions
E. Zurek, P. P. Edwards, and R. Hoffmann
Diazo Compounds
G. Maas
Water Splitting
J. N. H. Reek et al.
Complex Zeolites
M. O'Keeffe
ACIEFS 48 (44) 8151–8380 (2009) · ISSN 1433–7851 · Vol. 48 · No. 44
Cover Picture
Ulrika Westerlind, Hendrik Schrçder, Alexandra Hobel,
Nikola Gaidzik, Anton Kaiser, Christof M. Niemeyer, Edgar Schmitt,
Herbert Waldmann,* and Horst Kunz*
A synthetic vaccine consisting of a MUC1 tandem-repeat glycopeptide conjugated to
the tetanus toxoid protein was prepared and immunized in mice. A very strong
immune response with antibodies specific to the MUC1 glycopeptide was obtained, as
described in the Communication by H. Kunz and co-workers in issue 41 on
page 7551 ff. To further evaluate the specificity of the antibodies from this and other
synthetic vaccines, a MUC1 tandem-repeat glycopeptide microarray platform (see
cover picture) was developed by H. Kunz, H. Waldmann, and co-workers, as reported
in their Communication on page 8263 ff.
Diazo Compounds
The interest in diazo compounds continues thanks to their usefulness as versatile
synthetic building blocks. Even today, new methods and improved procedures are
being published. In the Minireview on page 8186 ff., G. Maas gives an overview of
recent studies.
Lithium–Ammonia Solutions
What causes the spectacular colors in the lithium–ammonia solutions that Humphry
Davy first observed 200 years ago? E. Zurek, P. P. Edwards, and R. Hoffmann and coworkers bring enlightenment in their Review on page 8198 ff.
Chemoselective Reactions
C. P. R. Hackenberger and co-workers describe in their Communication on
page 8234 ff. how the Staudinger-phosphite reaction can be used for the
chemoselective, metal-free transformation of azides in peptides and proteins in high
yields.
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associates, muc1, microarrays, serum, evaluate, tandem, repeat, int, cover, angel, chem, glycopeptides, specificity, monoclonalцantibody, picture, 442009, tumors
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