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Cover Picture УCascade-Release DendrimersФ Liberate All End Groups upon a Single Triggering Event in the Dendritic Core Self-Immolative Dendrimers (Angew. Chem. Int. Ed. 372003)

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Cover Picture
Franciscus M. H. de Groot,* Carsten Albrecht, Ralph Koekkoek,
Patrick H. Beusker, and Hans W. Scheeren,
Roey J. Amir, Neta Pessah, Marina Shamis, and Doron Shabat*
Cascade-release dendrimers or self-immolative dendrimers, as shown in the cover
picture, spontaneously release all the end-group molecules following a single
activation event. This triggering event induces a cascade of self-eliminations which
leads to complete dissociation of the dendrimer into its separate building blocks. As
the research groups of both F. M. H. de Groot (on page 4490 ff) and D. Shabat (on
page 4494 ff) describe, such functionally novel dendrimers open up new modes of
application of dendrimers, for example, for drug delivery.
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