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Edited by Wolf-Dieter Fessner and Thorleif Anthonsen Modern Biocatalysis Stereoselective and Environmentally Friendly Reactions Wiley-VCH 2009 400 pp.

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Book Review
Published online in Wiley Online Library: 25 August 2010
( DOI 10.1002/aoc.1718
Book Review
Modern Biocatalysis: Stereoselective and Environmentally
Friendly Reactions
Wiley-VCH, 2009, 400 pp.
price �5.00/�2.30 (hardback)
Biocatalysis continues to have significant potential for the preparation of chiral pharmaceuticals and
industrial chemical production under mild reaction conditions and
via a more sustainable strategy
than current chemical technologies. This multi-author book is
edited by Wolf-Dieter Fessner and
Thorleif Anthonsen, and results
from the EU-funded COST network
D25 entitled ?Applied Biocatalysis:
Stereoselective and Environmentally Friendly Reactions Catalyzed
by Enzymes? over a five year period. As such, it summarizes work in the areas of biocatalysis
research coordinated within that European network. The scope
of the book is wide ranging, reflecting the interdisciplinary field
of biocatalysis, from general concepts such as enzyme screening,
assays and solvent effects to specific classes of enzymes and reaction selectivities and synthetic strategies and opportunities using
enzymes. Aspects such as immobilized systems and microreactors
are also covered.
The book comprises 21 chapters, written by experts in their
field. References are given at the end of each chapter, up to 2008,
reflecting when the book was written. Of particular interest is
Chapter 2 on ?Immobilisation as a Tool for Improving Enzymes?
(Ulf Hanefeld), Chapter 13 ?Chemo-enzymatic Deracemization
Methods? (Davide Tessaro et al.) and Chapter 19, covering ?Novel
Strategies in Aldolase-catalyed Synthesis of Iminosugars? (Pere
Clape?s et al.). In other chapters enzymes catalysing carbon?carbon
bond formation, asymmetric oxidations and hydrolytic reactions
are described. Chapter 7 describing ?Factors Affecting Enantioselectivity: Allosteric Effects? (Elisabeth Egholm Jacobsen et al.) is also
a useful read. Several chapters will make ideal reading material
for undergraduates or graduates who have expertise in organic
synthesis, but wish to learn more about biocatalytic approaches
and how these might be incorporated into synthetic strategies.
This book will be of interest to all those working in or wishing
to move into the field of biocatalysis. Although, reflected by the
authorship, it may appeal most to members of the academic
community, there are chapters that will also be of interest to
industry. Biocatalysis is a large research field and therefore this
book cannot cover all relevant areas, but does provide information
on key concepts and specialist knowledge in the selected areas
represented by the expertise of the authors.
H. C. Hailes
University College London, UK
Appl. Organometal. Chem. 2011, 25, 82
c 2010 John Wiley & Sons, Ltd.
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400, biocatalysts, stereoselective, vch, reaction, fessner, environmentalism, thorleif, anthonsen, modern, friendly, wolf, 2009, edited, wiley, dieter
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