вход по аккаунту


Graphical Abstract Angew. Chem. Int. Ed. 402006

код для вставкиСкачать
The following Communications have been judged by at least two referees to be “very
important papers” and will be published online at soon:
C. M. Erben, R. P. Goodman, A. J Turberfield*
Single-Molecule Protein Encapsulation in a Rigid DNA Cage
F. D. Lewis,* H. Zhu, P. Daublain, B. Cohen, M. R. Wasielewski*
Hole Mobility in DNA A-Tracts
S. Sekharan, M. Sugihara, V. Buss*
Origin of Spectral Tuning in Rhodopsin: It is Not the Binding
H. Braunschweig,* T. Kupfer, M. Lutz, K. Radacki, F. Seeler,
R. Sigritz
Metal-Mediated Diboration of Alkynes with
[2]Borametalloarenophanes under Stoichiometric,
Homogeneous, and Heterogenous Conditions
M. E. Chiu, D. J. Watson, G. Kyriakou, M. S. Tikhov, R. M. Lambert*
Tilt the Molecule and Change the Chemistry: Mechanism of
S-Promoted Chemoselective Catalytic Hydrogenation of
Crotonaldehyde on Cu(111)
H. Ma, T. P. Spaniol, J. Okuda*
Highly Heteroselective Ring-Opening Polymerization of
rac-Lactide Initiated by Bis(phenolato) Scandium Complexes
Organic Chemistry: Nakamura, Bach, and Dupont honored
Polymorphism in the Pharmaceutical
Rolf Hilfiker
reviewed by R. K. Harris
High Temperature Superconductor Bulk
Gernot Krabbes, G%nter Fuchs
Wolf-R%diger Canders, Hardo May,
Ryszard Palka
reviewed by O. Eibl
Which pathway? Aerobic Pd-catalyzed
oxidation reactions couple organic-substrate oxidation to the reduction of O2.
Two pathways are prevalent for the
regeneration of the active PdII catalyst
(see scheme; SubH2 = substrate;
SubOx = oxidized substrate), and recent
studies have provided a deeper fundamental understanding of the interactions
of Pd with O2.
Aerobic Oxidations
K. M. Gligorich,
M. S. Sigman*
6612 – 6615
Mechanistic Questions about the
Reaction of Molecular Oxygen with
Palladium in Oxidase Catalysis
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
The heat of formation of cyclobutadiene
has recently been determined by Kass and
co-workers. This determination is taken as
an occasion to reflect on the difficulty to
extract from this number the “antiaromatic destabilization” and the strain
energy of this most fundamental species.
6616 – 6619
T. Bally*
Cyclobutadiene: The Antiaromatic
Chemical biology in action: The progress
in the fields of lipidated-peptide synthesis
and protein-ligation methods has enabled
access to natural and modified Ras
GTPases. The generated peptides and
proteins have served to elucidate
unsolved biological questions in the field
of the Ras-superfamily GTPases. Pal =
palmitoyl, Far = farnesyl.
Bioorganic Chemistry
L. Brunsveld, J. Kuhlmann, K. Alexandrov,
A. Wittinghofer, R. S. Goody,
H. Waldmann*
6622 – 6646
Lipidated Ras and Rab Peptides and
Proteins—Synthesis, Structure, and
Solvent-Directed Self-Assembly
T. M. Hermans, J. Choi, B. G. G. Lohmeijer,
G. Dubois, R. C. Pratt, H.-C. Kim,
R. M. Waymouth,
J. L. Hedrick*
6648 – 6652
An inverse relationship: Mixtures of
poly(dimethylacrylamide)-block-polylactide copolymer (PDMA-b-PLA) with organosilicate oligomers (PMSSQ) selectively
sequestered into the PDMA phase form
micelles and inverse micelles in solution
depending on the solvent. The micellar
structures are imprinted into the resulting
cured organosilicate to give monoliths or
assemblies of densely packed organosilicate nanoparticles, respectively.
For the USA and Canada:
Edition (ISSN 1433-7851) is published weekly
by Wiley-VCH PO Box 191161, D 69451 Weinheim, Germany. Air freight and mailing in the
USA by Publications Expediting Inc. 200
Meacham Ave., Elmont, NY 11003. Periodicals
postage paid at Jamaica NY 11431. US POSTMASTER: send address changes to Angewandte
Chemie, Wiley-VCH, 111 River Street, Hoboken,
NJ 07030. Annual subscription price for institutions: US$ 5685/5168 (valid for print and
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
Application of Solvent-Directed Assembly
of Block Copolymers to the Synthesis of
Nanostructured Materials with Low
Dielectric Constants
electronic / print or electronic delivery); for
individuals who are personal members of a
national chemical society prices are available
on request. Postage and handling charges
included. All prices are subject to local VAT/
sales tax.
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
V. Lavallo, Y. Ishida, B. Donnadieu,
G. Bertrand*
6652 – 6655
Isolation of Cyclopropenylidene–Lithium
Adducts: The Weiss–Yoshida Reagent
Luck is important: In the 1970s, Yoshida
and Weiss both had the right cyclopropenium cation precursor. With the right
counteranion, they would have isolated
the first carbene–lithium adduct (see
scheme; C black, N blue, O red, Li pink,
B yellow, F green). With the right base and
counteranion combination, they would
have isolated the first stable free carbene.
It’s all in the spin: The initial sticking
probability of O2 on a CO-precovered
Pd(100) surface and the rate of CO2
production are strongly affected by the
alignment of the incoming molecules.
Whereas O2 molecules impinging with
cartwheel-like motion can stick in small
holes, molecules moving with helicopterlike motion need a large array of free sites
(see picture).
Surface Chemistry
A. Gerbi, L. Savio, L. Vattuone,* F. Pirani,
D. Cappelletti, M. Rocca
6655 – 6658
Role of Rotational Alignment in
Dissociative Chemisorption and
Oxidation: O2 on Bare and CO-Precovered
Economic power: A robust and low-cost
microbial fuel cell has a tungsten carbide
anode electrocatalyst, a pyrolyzed iron(III)
phthalocyanine cathode catalyst for
oxygen reduction, and hydrogen-producing soil bacteria as biocatalysts (see
picture). Power and current densities of
up to 585 mWcm2 and 3 mA cm2,
respectively, are achieved.
Fuel Cells
Colorimetric guest signaling is effected by
a supramolecular approach that uses a
mesoporous hybrid solid functionalized
with gatelike scaffoldings. When the gate
is open, a dye (see scheme; orange dots)
embedded in the pore walls of a mesoporous solid is released into the solution
giving color. If the appropriate anion (red
dots) is present the gate is closed, the dye
is locked into the pores, and the solution
remains colorless.
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
M. Rosenbaum, F. Zhao, U. SchrNder,*
F. Scholz
6658 – 6661
Interfacing Electrocatalysis and
Biocatalysis with Tungsten Carbide: A
High-Performance, Noble-Metal-Free
Microbial Fuel Cell
R. Casasffls, E. Aznar, M. D. Marcos,
R. MartPnez-MQRez,* F. SancenSn, J. Soto,
P. AmorSs
6661 – 6664
New Methods for Anion Recognition and
Signaling Using Nanoscopic Gatelike
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Supramolecular Chemistry
A. R. Williams, B. H. Northrop, T. Chang,
J. F. Stoddart,* A. J. P. White,
D. J. Williams*
6665 – 6669
Molecules in suits: Supramolecular
assistance leads to the self-assembly of a
mechanically interlocked compound
called a suit[2]ane (see picture). Two
bisformyldipyrido[24]crown-8 rings (red)
recognize and encircle two secondary
ammonium ion centers on a rigid linear
scaffold (blue for the most part in the
picture) with a bulky midriff, followed by
the dynamic formation of four imine
bonds involving two p-phenylenediamine
molecules as linkers.
R. P. Bontchev, M. Nyman*
A new geometry for polyoxoniobates is
observed in {Nb24O72H9}15, the largest
isopolyoxoniobate cluster anion known to
date. Its structural evolution from isolated
Lindqvist anions [Nb6O19]8 and the cyclic
pyrochlore unit [Nb6O30] through to the
complex dimer [({Nb24O72H9}
{Cu(en)2(H2O)}2{Cu(en)2})2]18 is discussed.
6670 – 6672
Evolution of Polyoxoniobate Cluster
Asymmetric Self-Assembly
Asymmetric disk-shaped Janus micelles
form spontaneously and reversibly when
simple water-soluble diblock copolymers
in aqueous solutions are mixed. The
combination of associative and segregative phase separation within one nanostructure results in a disk-shaped micelle
with a complex coacervate core and an
asymmetric water-swollen corona which is
microphase-separated into two distinct
domains or faces.
I. K. Voets, A. de Keizer, P. de Waard,
P. M. Frederik, P. H. H. Bomans,
H. Schmalz, A. Walther, S. M. King,
F. A. M. Leermakers,
M. A. Cohen Stuart*
6673 – 6676
Double-Faced Micelles from WaterSoluble Polymers
Carbon Nanotubes
H. Isobe,* T. Tanaka, R. Maeda, E. Noiri,
N. Solin, M. Yudasaka, S. Iijima,
E. Nakamura*
6676 – 6680
Preparation, Purification,
Characterization, and Cytotoxicity
Assessment of Water-Soluble, TransitionMetal-Free Carbon Nanotube Aggregates
The risk assessment of carbon materials,
an important topic in nanomaterials
research, has been hampered by the lack
of characterizable samples. Transitionmetal-free carbon nanohorn aggregates
have been prepared that are covalently
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
bonded aggregates of single-walled
nanotubes. They were functionalized to
give water-soluble derivatives (see picture), which were incubated with cells in
cytotoxicity assessments.
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
A mixed-valent subnitride host structure
1:5þ 3
with parallel channels (Ca2þ
N4 )
3 Ca4
readily accommodates metal guest chains
(see picture; Ca2+ orange, Ca1.5+ red,
N green, M black). These incommensurate guests, which comprise linear chains
of equidistant metal atoms (M = Ag, Ga)
or fragments thereof (M = In, Tl), interact
only weakly with their hosts.
Host–Guest Systems
The carbon–phosphorus–antimony cage
of P2C2tBu2SbCl (see picture) adopts an
envelope-type structure which is quite
distinct from its phosphorus analogue,
the tricyclic compound P2C2tBu2PCl. DFT
calculations reveal that subtle changes in
electronic structure as a result of the inertpair effect lead to profound differences in
structural and dynamic behavior.
Envelope Clusters
P. HNhn, G. Auffermann, R. Ramlau,
H. Rosner, W. Schnelle,
R. Kniep*
6681 – 6685
(Ca7N4)[Mx] (M = Ag, Ga, In, Tl): Linear
Metal Chains as Guests in a Subnitride
C. Fish, M. Green,* J. C. Jeffery, R. J. Kilby,
J. M. Lynam,* J. E. McGrady,*
D. A. Pantazis, C. A. Russell,*
C. E. Willans
6685 – 6689
A Main-Group Analogue of Housene: The
Subtle Influence of the Inert-Pair Effect in
Group 15 Clusters
J. Lim, B. C. Grove, A. Roth,
R. R. Breaker*
6689 – 6693
A tweak here, a tweak there: A series of
analogues of glucosamine-6-phosphate
(GlcN6P, see picture) was used to examine the molecular-recognition characteristics of a glmS ribozyme that is activated
by this ligand. Although several functional
groups on the ligand are critical for
binding, there are opportunities to create
new analogues that fully trigger ribozyme
Characteristics of Ligand Recognition by a
glmS Self-Cleaving Ribozyme
Molecular Recognition
O. Francesconi, A. Ienco, G. Moneti,
6693 – 6696
C. Nativi, S. Roelens*
A Self-Assembled Pyrrolic Cage
Receptor Specifically Recognizes
Fishing for b-glucose: Three dialdehydic
and two triamino components quantitatively self-assemble into a pyrrolic cage
receptor that effectively discriminates
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
d-glucopyranosides among various
monosaccharides and recognizes the
b anomer exclusively.
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Lead Iron Oxides
Shear innovation: By analyzing the crystallographic shear (CS) structures of
“Pb2Fe2O5” (see picture; spheres Pb,
polyhedra FeO6/FeO5), new building principles are derived for perovskite-based
compounds containing cations with a
lone electron pair in the A sites of the
perovskite structure. The chemical composition can be adjusted by varying the
orientation of the CS planes and the
thickness of the perovskite slabs between
the planes.
A. M. Abakumov,* J. Hadermann, S. Bals,
I. V. Nikolaev, E. V. Antipov,
G. Van Tendeloo
6697 – 6700
Crystallographic Shear Structures as a
Route to Anion-Deficient Perovskites
Catalytic Isomerization
J. Xu, J. Y. Ying*
6700 – 6704
A Highly Active and Selective
Nanocomposite Catalyst for C7+ Paraffin
No coking: A Pt/WO3/Al-ZrOx nanocomposite enables the efficient conversion of
various hydrocarbons at a temperature as
low as 150 8C (see figure, X = conversion)
without deep cracking or coking problems. This novel catalyst might potentially be used for the production of highoctane fuel with a low content of aromatics by converting n-alkanes into their
multibranched isomers with excellent
Furan Synthesis
J. Zhang, H.-G. Schmalz*
6704 – 6707
Gold(I)-Catalyzed Reaction of 1-(1Alkynyl)-cyclopropyl Ketones with
Nucleophiles: A Modular Entry to
Highly Substituted Furans
Ring round: 1-Acyl-1-alkynyl-cyclopropanes smoothly react with nucleophiles in
the presence of a gold(I) catalyst to afford
substituted furans in a fully atom-eco-
Iron(III) Compounds
P. J. Alonso,* A. B. Arauzo, J. ForniYs,
M. A. GarcPa-Monforte, A. MartPn,
J. I. MartPnez, B. MenjSn,* C. Rillo,
J. J. SQiz-Garitaonandia
6707 – 6711
nomical fashion (see scheme; Nu = nucleophile, Tf = trifluoromethanesulfonyl).
The reaction tolerates a wide range of
Square-planar iron(III) species bearing no
axial ligands can still behave as spinadmixed systems (S = 3=2 , 5=2 ). The highly
unusual homoleptic s-organoiron complex [Li(thf)4][FeIII(C6Cl5)4] (see anion in
picture; green Cl, gray C) is an example of
such a system.
A Square-Planar Organoiron(III)
Compound with a Spin-Admixed State
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
Top stuff: The configuration of tetrafluoromethane–water is driven by dipole–
dipole interactions rather than hydrogen
bonds. The complex, which consists of a
planar and a spherical moiety, is an
asymmetric top in its equilibrium conformation, but its effective behavior is that of
a symmetric top, owing to its high internal
Candidate for Candida: A high-yielding
and versatile synthesis of bengazole A has
been developed; the first to provide
access to a single stereoisomer of the
natural product. Key steps include the
construction of the 2,4-disubstituted oxazole under mild conditions and a diastereoselective 1,3-dipolar cycloaddition.
Dipole–Dipole Interactions
W. Caminati,* A. Maris, A. Dell’Erba,
P. G. Favero
6711 – 6714
Dynamical Behavior and Dipole–Dipole
Interactions of Tetrafluoromethane–Water
Total Synthesis
J. A. Bull, E. P. Balskus, R. A. J. Horan,
M. Langner, S. V. Ley*
6714 – 6718
Stereocontrolled Total Synthesis of
Bengazole A: A Marine Bisoxazole
Natural Product Displaying Potent
Antifungal Properties
Transfer Hydrogenation
X. Wu, J. Liu, X. Li, A. Zanotti-Gerosa,
F. Hancock, D. Vinci, J. Ruan,
J. Xiao*
6718 – 6722
Water as solvent: A fast, selective, and
high-yielding transfer hydrogenation of a
wide range of aldehydes is achieved using
IrIII catalysts containing simple ethylenediamine (en) ligands (see scheme; Ts =
p-toluenesulfonyl, TOF = turnover frequency). This procedure is suitable for
aldehydes with a wide range of functional
Seeing is believing: Treatment of tryptophan with formic acid and hydrochloric
acid generates a violet-blue color. The
reaction is very specific, and can be used
to identify tryptophan in a mixture of
amino acids, or corroborate the existence
of tryptophyl groups in peptides or proteins (see picture; A: blank; B: a mixture
of 9 representative amino acids; C: tryptophan; D: mixture (B) and tryptophan; E:
reduced glutathione; F: egg-white albumin).
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
On Water and in Air: Fast and Highly
Chemoselective Transfer Hydrogenation
of Aldehydes with Iridium Catalysts
Analytical Methods
Z. Bao, S. Sun, J. Li, X. Chen, S. Dong,
H. Ma*
6723 – 6725
Direct Identification of Tryptophan in a
Mixture of Amino Acids by the Naked Eye
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Synthetic Methods
S. Couty, C. Meyer, J. Cossy* 6726 – 6730
Diastereoselective Gold-Catalyzed
Cycloisomerizations of Ene-Ynamides
Around they go: 1,6-Ene-ynamides
undergo highly diastereoselective goldcatalyzed cycloisomerizations that lead to
functionalized cyclobutanones or carbonyl
compounds with a 2-azabicyclo[3.1.0]hexane subunit, depending on the
substitution pattern (Ts = p-toluenesulfonyl).
Desperately seeking silyenylium: Electrophilic attack of silylene 1 (R = 2,6-diisopropylphenyl) by B(C6F5)3 and H+ afforded
the silylene-like zwitterion 2 and the “free”
silyliumylidene cation 3 (in the presence
of the noncoordinating [B(C6F5)4] anion),
respectively. Cations 2 and 3 represent a
novel class of low-coordinate silicon cations with promising potential for the
synthesis of heteroleptic silylenes.
Silicon Chemistry
M. Driess,* S. Yao, M. Brym,
6730 – 6733
C. van W%llen
Low-Valent Silicon Cations with TwoCoordinate Silicon and Aromatic
Homocyclic Phosphorus Compounds
J. J. Weigand,* N. Burford,*
M. D. Lumsden, A. Decken 6733 – 6737
A Melt Approach to the Synthesis of
catena-Phosphorus Dications To Access
Derivatives of [P6Ph4R4]2+
Biaryl Synthesis
B. O. Ashburn, R. G. Carter* 6737 – 6741
Diels–Alder Approach to Polysubstituted
Biaryls: Rapid Entry to Tri- and Tetra-orthosubstituted Phosphorus-Containing
P analogues of cyclohexane: The first
examples of hexaphosphorus homocyclic
dications [P6Ph4R4]2+ (R = Ph, Me; see
picture, P yellow, C dark gray) were prepared in a melt reaction from readily
accessible starting materials in essentially
quantitative yield. X-ray analysis of the
dications reveals cyclohexane-like twistboat and chair conformations of the
phosphorus homocycle in the solid state.
Rapid construction: A Diels–Alder-based
approach to the synthesis of highly functionalized biaryls from readily available
precursors is disclosed. The utility of
these biaryl templates in palladiummediated couplings is explored along with
subsequent reductions of the nitro and
phosphine oxide moieties. Finally, initial
application of a synthesized biaryl as a
highly active ligand in palladium-mediated coupling is carried out.
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
A C3-symmetric palladium complex
formed from a new readily accessible and
rigid tripodal phosphorus-based ligand
has no chirality in either of its pendent
arms but is intrinsically chiral (see picture). The potential of the racemic complex as a catalyst is demonstrated in
several Suzuki cross-coupling reactions.
The enantiomerically pure compound is
also tested for asymmetric catalysis in a
model reaction.
Homogeneous Asymmetric Catalysis
M. Ciclosi, J. Lloret, F. Estevan,
P. Lahuerta,* M. Sanaffl,
J. PYrez-Prieto*
6741 – 6744
A C3-Symmetric Palladium Catalyst with a
Phosphorus-Based Tripodal Ligand
C. Pr[sang, P. Amseis, D. Scheschkewitz,
G. Geiseler, W. Massa, M. Hofmann,
A. Berndt*
6745 – 6747
Charge separation in the reference molecules is the main reason for the unusually
high aromatic stabilization energies
(ASEs) of nonclassical 1-sila-3,4-diboracyclopentanes of type 1. Compound 1 a
was synthesized, and the ASE for its
model compound 1 b was computed. In
reference molecule 2 the two electrons,
which are cyclically delocalized in 1 b, are
localized in a BB bond (R = SiMe3,
Dur = 2,3,5,6-tetramethylphenyl).
Strong Neutral Homoaromatics
A light remedy to overdosing: Aptamers
with an intramolecular “caged” antisense
region remain active until they are irradiated. Upon irradiation, the antisense
activity is released and the aptamer
refolds into an inactive structure (see
Antisense Agents
A. Heckel,* M. C. R. Buff, M.-S. L. Raddatz,
J. M%ller, B. PNtzsch,
6748 – 6750
G. Mayer*
An Anticoagulant with Light-Triggered
Antidote Activity
Brønsted Acid Catalysis
M. Rueping,* A. P. Antonchick,
T. Theissmann
6751 – 6755
Remarkably Low Catalyst Loading in
Brønsted Acid Catalyzed Transfer
Hydrogenations: Enantioselective
Reduction of Benzoxazines,
Benzothiazines, and Benzoxazinones
A highly efficient transfer hydrogenation
of benzoxazines, benzothiazines, and
benzoxazinones with as low as 0.01 mol %
binol phosphate catalyst furnishes the
dihydro-2H-benzoxazines, -benzothiazines, and -benzoxazinones in good yields
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
and with excellent enantioselectivities
(see scheme). Particularly noteworthy are
the mild reaction conditions and the wide
scope of substrates, including sulfur-containing compounds.
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Reminiscent of a snowflake: The dimer of
a hydroxy-substituted oligosilane dendrimer (see picture, left; Si yellow, C green,
H white, O red) is remarkably stable
according to IR spectroscopy and DFT
calculations. Strong intermolecular
hydrogen bonds are not only the glue that
holds the “silicon snowflake” together, but
are also the key to understanding the
relationship between the conformation of
the oligosilane backbone and its thermochromic behavior.
U. J[ger-Fiedler, M. KNckerling, R. Ludwig,
A. Wulf, C. Krempner*
6755 – 6759
Hydroxy-Substituted Oligosilane
Dendrimers: Controlling the Electronic
Properties through Hydrogen Bonding
Antimicrobial Coatings
A. D. Fuchs, J. C. Tiller*
Kills germs on contact! Environmentally
friendly aqueous dispersions of polymer
nanobeads with a surface-grafted antimicrobial emulsifier were prepared. Coatings
prepared from these dispersions (see
picture) kill microbes on contact, without
releasing a biocide.
6759 – 6762
Contact-Active Antimicrobial Coatings
Derived from Aqueous Suspensions
Angewandte’s Sister Journals
For more information on
ChemMedChem see
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
The authors have recently determined that the structure of the proposed [4þ3] oxidative
cyclization product 35 (see Scheme 7 in the original Communication) was incorrectly
assigned. The previous structure (35) as well as the revised structure (35’) are shown
below. The authors apologize for the error, but point out that the chemistry leading up to
the oxidative cyclization reported in Scheme 7 is correct.
Synthesis of the Tetracyclic Core of the
Tetrapetalones through Transannular
Oxidative [4þ3] Cyclization
X. Wang, J. A. Porco, Jr.*
Angew. Chem. Int. Ed. 2005, 44
DOI 10.1002/anie.200500247
In Figure 1 B of this Communication, the tile labels in the annealing structure scheme
appeared incorrectly. The correct numbering is shown below (Figure 1).
Finite-Size, Fully Addressable DNA Tile
Lattices Formed by Hierarchical Assembly
S. H. Park, C. Pistol, S. J. Ahn,
J. H. Reif, A. R. Lebeck, C. Dwyer,*
T. H. LaBean*
Angew. Chem. Int. Ed. 2006, 45
DOI 10.1002/anie.200503797
Figure 1. DNA tile and NA structures and assembly schemes. A) Schematic drawings of the strand trace in cross tiles with strand names marked
(arm, shell, and loop). B) MSS strategy and constructs. A converging-stream diagram of the four-step assembly process starting with eight tubes
of two tiles each (i) and concluding with one tube containing all 16 tiles (iv). The blue and red diagram shows the placement of tiles (1 through
16) in the NA and the identity of loop strands (A-loops are blue and B-loops are red). The bottom six panels are AFM height images with
dimensions as labeled and height scale from 0 to 3 nm. Panels i)–iv) correspond to the same labels as in the annealing scheme above; thus,
i) 1 8 2 NA, ii) 2 8 2 NA, iii) 2 8 4 NA, and iv) 4 8 4 NA. The two bottom AFM images are zoom-out and zoom-in pictures of (iv), with error-free NAs
in the zoom-out image circled in turquoise. C) MD strategy and constructs. A converging-stream diagram of the two-step assembly starts with 16
tubes with one tile each (i) and goes directly to one tube of 16 tiles (ii). The blue and red diagram shows the placement of A-loop and B-loop tiles
in the final NA. The bottom four panels are AFM height images with i) showing single tiles and ii) showing complete 4 8 4 NAs. The two bottom
panels are zoom-out images to show the increased production yield of defect-free assemblies from the two-step method.
Angew. Chem. Int. Ed. 2006, 45, 6596 – 6607
2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Без категории
Размер файла
1 947 Кб
abstract, int, angel, chem, 402006, graphical
Пожаловаться на содержимое документа