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Inside Cover A Potent Trans-Diimine Platinum Anticancer Complex Photoactivated by Visible Light (Angew. Chem. Int. Ed. 472010)

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Photoactivation
can be used …
… to activate anticancer drugs selectively just at the site of a tumor. Such targeted
treatments promise fewer side effects and may address the problem of acquired
resistance associated with drugs such as cisplatin. P. J. Sadler and co-workers show in
their Communication on page 8905 ff. that the octahedral complex trans,trans,trans[PtIV(N3)2(OH)2(py)2] is potentially cytotoxic towards a number of cell lines when
activated by blue light, with no toxicity in the absence of irradiation.
Inside Cover
Nicola J. Farrer, Julie A. Woods, Luca Salassa, Yao Zhao,
Kim S. Robinson, Guy Clarkson, Fiona S. Mackay, and Peter J. Sadler*
Photoactivation can be used to activate anticancer drugs selectively just at the site of
a tumor. Such targeted treatments promise fewer side effects and may address the
problem of acquired resistance associated with drugs such as cisplatin. P. J. Sadler and
co-workers show in their Communication on page 8905 ff. that the octahedral
complex trans,trans,trans-[PtIV(N3)2(OH)2(py)2] is potentially cytotoxic towards a
number of cell lines when activated by blue light, with no toxicity in the absence of
irradiation.
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platinum, complex, light, 472010, int, cover, angel, chem, insider, transp, potent, anticancer, diimine, visible, photoactivated
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