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Inside Cover Biotransformation on PolymerЦPeptide Conjugates A Versatile Tool to Trigger Microstructure Formation (Angew. Chem. Int. Ed. 352009)

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The
BioSwitch Concept …
… uses posttranslational modification to control the formation of hierarchical microstructures. As described by H. Khnle and H. G. Brner in their Communication on
page 6431 ff, the incorporation of phosphorylated threonine residues into the peptide
segment of a polymer–peptide conjugate effectively suppresses the self-assembly of the
bioconjugate. The acid phosphatase cleaves the phosphate groups from the peptide
segment, activates the peptide function of the b-sheet aggregation domain, and triggers
the self-assembly process.
Inside Cover
Hans Khnle and Hans G. Bçrner*
The BioSwitch Concept uses posttranslational modification to control the formation
of hierarchical microstructures. As described by H. Khnle and H. G. Bçrner in their
Communication on page 6431 ff, the incorporation of phosphorylated threonine
residues into the peptide segment of a polymer–peptide conjugate effectively
suppresses the self-assembly of the bioconjugate. The acid phosphatase cleaves the
phosphate groups from the peptide segment, activates the peptide function of the bsheet aggregation domain, and triggers the self-assembly process.
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versatile, biotransformation, formation, tool, polymerцpeptide, int, cover, angel, chem, conjugate, insider, trigger, microstructure, 352009
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