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Inside Cover Chemical Tags Facilitate the Sensing of Individual DNA Strands with Nanopores (Angew. Chem. Int. Ed. 302008)

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Chemical
tags …
… help detect separate bases in individual DNA strands, as demonstrated by S. Howorka
and N. Mitchell in the Communication on page 5565 ff. In the sensing strategy, a single
DNA strand is threaded through a “nanotunnel”. Owing to their larger diameter,
individual bases with attached chemical tags are slowed at the narrow constriction. The
pattern of modified and unmodified bases gives rise to a characteristic current signal for
the DNA. The picture was prepared by Hugh Martin.
Inside Cover
Nick Mitchell and Stefan Howorka*
Chemical tags help detect separate bases in individual DNA strands, as demonstrated
by S. Howorka and N. Mitchell in the Communication on page 5565 ff. In the sensing
strategy, a single DNA strand is threaded through a “nanotunnel”. Owing to their
larger diameter, individual bases with attached chemical tags are slowed at the narrow
constriction. The pattern of modified and unmodified bases gives rise to a
characteristic current signal for the DNA. The picture was prepared by Hugh Martin.
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strands, dna, tags, facilitates, 302008, int, cover, angel, chemical, chem, sensing, nanopore, insider, individual
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