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Inside Cover Lewis Acid Activated Synthesis of Highly Substituted Cyclopentanes by the N-Heterocyclic Carbene Catalyzed Addition of Homoenolate Equivalents to Unsaturated Ketoesters (Angew. Chem. Int. Ed. 72011)

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A. highly diastereo- and enantioselective …
… N-heterocyclic carbene catalyzed/titanium(IV)-mediated homoenolate addition to
b,g-unsaturated a-ketoesters to assemble cyclopentanols with four contiguous stereogenic centers is described by Scheidt and co-workers in their Communication on
page 1678 ff. The Lewis acid is essential for the reaction and a wide range of b,gunsaturated a-ketoesters and enals are tolerated, with the products obtained in 52–85%
yield and up to 99% ee.
Inside Cover
Daniel T. Cohen, Benoit Cardinal-David, and Karl A. Scheidt*
A highly diastereo- and enantioselective N-heterocyclic carbene catalyzed/
titanium(IV)-mediated homoenolate addition to b,g-unsaturated a-ketoesters to
assemble cyclopentanols with four contiguous stereogenic centers is described by
Scheidt and co-workers in their Communication on page 1678 ff. The Lewis acid is
essential for the reaction and a wide range of b,g-unsaturated a-ketoesters and enals
are tolerated, with the products obtained in 52–85% yield and up to 99% ee.
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acid, ketoesters, homoenolate, carbene, unsaturated, cyclopentane, catalyzed, 72011, equivalence, int, cover, angel, synthesis, chem, additional, insider, heterocyclic, substituted, lewis, highly, activated
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