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Inside Cover O-Glycoside Orientation Is an Essential Aspect of BaseJ Recognition by the Kinetoplastid DNA-Binding Protein JBP1 (Angew. Chem. Int. Ed. 162007)

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Inside Cover
Rajesh K. Grover, Stephanie J. K. Pond, Qizhi Cui, Prem Subramaniam,
David A. Case, David P. Millar, and Paul Wentworth, Jr.*
Protein recognition of DNA is key to the control of genome expression within living
cells. Kinetoplastid parasites like those in the background possess the protein JBP1,
which binds to double-stranded DNA containing the glycosylated base shown
(nucleoside dJ). In their Communication on page 2839 ff., P. Wentworth, Jr. et al.
analyze the binding and find that JBP1 recognizes a critical edge-on conformation of
the pyranosyl ring of nucleoside dJ. These results are important for the development
of new biological targets for antiparasitic drugs.
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essential, aspects, dna, recognition, base, int, orientation, cover, angel, kinetoplastida, chem, 162007, protein, glycosides, insider, binding, jbp1
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