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Inside Cover Site-Directed Asymmetric Quaternization of a Peptide Backbone at a C-Terminal Azlactone (Angew. Chem. Int. Ed. 42009)

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A. D2-symmetric chiral tetraaminophosphonium salt …
… functions as an effective phase-transfer catalyst to achieve highly stereoselective
alkylation of C-terminal azlactones of growing peptides, as described by T. Ooi and coworkers in their Communication on page 733 ff. The judicious combination of this
method with a direct ligation process is a practical strategy for incorporating various
chiral, non-racemic a,a-dialkyl-a-amino acids into a specific site of the peptide strand.
Inside Cover
Daisuke Uraguchi, Yoshihiro Asai, and Takashi Ooi*
A D2-symmetric chiral tetraaminophosphonium salt functions as an effective phasetransfer catalyst to achieve highly stereoselective alkylation of C-terminal azlactones
of growing peptides, as described by T. Ooi and co-workers in their Communication
on page 733 ff. The judicious combination of this method with a direct ligation
process is a practical strategy for incorporating various chiral, non-racemic a,adialkyl-a-amino acids into a specific site of the peptide strand.
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azlactones, site, asymmetric, quaternization, terminal, backbone, int, cover, angel, chem, 42009, insider, directed, peptide
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