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Inside Cover Stability and Shape of HepatitisB Virus Capsids InVacuo (Angew. Chem. Int. Ed. 332008)

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Precise
biophysical characterization …
… of macromolecular complexes is possible by mass spectrometry. Heck et al. report in
their Communication on page 6247 ff. how two distinct icosahedral geometries of intact
megaDalton capsids of the hepatitis B virus (a major human pathogen) can be measured
and separated by mass spectrometry. Ion mobility measurements established that the
viral structures are largely preserved in vacuo and two distinct conformers per capsid
geometry could be distinguished.
Inside Cover
Benjamin Glettner, Feng Liu, Xiangbing Zeng, Marko Prehm,
Ute Baumeister, Goran Ungar,* and Carsten Tschierske*
Precise biophysical characterization of macromolecular complexes is possible by mass
spectrometry. Heck et al. report in their Communication on page 6247 ff. how two
distinct icosahedral geometries of intact megaDalton capsids of the hepatitis B virus
(a major human pathogen) can be measured and separated by mass spectrometry. Ion
mobility measurements established that the viral structures are largely preserved
in vacuo and two distinct conformers per capsid geometry could be distinguished.
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int, cover, angel, invacuo, chem, hepatitis, virus, insider, 332008, shape, capsid, stability
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