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Inside Cover Synthesis and Biological Activity of Argiotoxin636 and Analogues Selective Antagonists for Ionotropic Glutamate Receptors (Angew. Chem. Int. Ed. 172009)

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Spiders
of the genus Argiope, …
… such as Argiope lobata, contain polyamine toxins that are potent but nonselective
blockers of glutamate receptors. However, by very subtle modifications of the structure
of native toxins, it is possible to obtain selectivity for subtypes of these receptors, as
described by K. Strømgaard and co-workers in their Communication on page 3087 ff.
Inside Cover
Jared K. Nelson, Sidsel U. Frølund, Dennis B. Tikhonov,
Anders S. Kristensen, and Kristian Strømgaard*
Spiders of the genus Argiope, such as Argiope lobata, contain polyamine toxins that
are potent but nonselective blockers of glutamate receptors. However, by very subtle
modifications of the structure of native toxins, it is possible to obtain selectivity for
subtypes of these receptors, as described by K. Strømgaard and co-workers in their
Communication on page 3087 ff.
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selective, biological, glutamate, analogues, int, cover, angel, synthesis, chem, activity, antagonisms, receptors, insider, 172009, ionotropic, argiotoxin636
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