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Spotlights on our sister journals Angew. Chem. Int. Ed. 332009

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Spotlights …
Electron Transport
Y. Nishimori, K. Kanaizuka, T. Kurita, T. Nagatsu, Y. Segawa,
F. Toshimitsu, S. Muratsugu, M. Utsuno, S. Kume, M. Murata,
H. Nishihara*
Superior Electron-Transport Ability of p-Conjugated Redox Molecular
Wires Prepared by the Stepwise Coordination Method on a Surface
Hop around the block: p-Conjugated redox complex molecular wires
that have been constructed on a gold surface through a convenient
stepwise ligand–metal coordination method have been shown to
exhibit high long-range electron-transport abilities. This transport is
caused by facile sequential electron hopping between neighboring
metal–complex units within the wire.
Chem. Asian J.
DOI: 10.1002/asia.200900072
Enzyme Catalysis
N. Richter, M. Neumann, A. Liese, R. Wohlgemuth, T. Eggert,
W. Hummel*
Characterisation of a Recombinant NADP-Dependent Glycerol
Dehydrogenase from Gluconobacter oxydans and its Application in the
Production of l-Glyceraldehyde
It’s elementary, dear Watson: We describe the characterisation of a
NADP-dependent glycerol dehydrogenase from Gluconobacter oxydans
(Gox1615), and show that the enzyme can be applied in the kinetic
resolution of glyceraldehydes (see scheme), which is a versatile chiral
building block in the production of fine chemicals, pharmaceuticals
and natural products.
DOI: 10.1002/cbic.200900193
Biological Membranes
C. Amatore,* A. I. Oleinick, O. V. Klymenko, I. Svir*
Theory of Long-Range Diffusion of Proteins on a Spherical Biological
Membrane: Application to Protein Cluster Formation and Actin-Comet
Tail Growth
Diffusional recruitment of proteins: Classical Brownian motion analysis describes the long-range movements of biomolecules on a spherical biological membrane. This protein diffusion process is prerequisite
for the assembly of proteins which then cooperatively catalyze the
polymerization of actin monomers to sustain the growth of actin tails
(see picture).
DOI: 10.1002/cphc.200900176
Drug Discovery
S. Patterson, D. C. Jones, E. J. Shanks, J. A. Frearson, I. H. Gilbert,
P. G. Wyatt, A. H. Fairlamb*
Synthesis and Evaluation of
1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as
Inhibitors of Trypanothione Reductase
Antiparasitic agents: 32 analogues of the phencyclidine analogue
BTCP were synthesised and their inhibitory activities against Trypanosoma brucei trypanothione reductase, a genetically validated drug
target in the T. brucei parasite were evaluated. The most promising
analogues were evaluated further against bloodstream T. brucei.
2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/cmdc.200900098
Angew. Chem. Int. Ed. 2009, 48, 5990 – 5991
… on our Sister Journals
Phosphide Tellurides
K. Tschulik, M. Ruck, M. Binnewies, E. Milke, S. Hoffmann,
W. Schnelle, B. P. T. Fokwa, M. Gilleßen, P. Schmidt*
Chemistry and Physical Properties of the Phosphide Telluride Zr2PTe2
Eur. J. Inorg. Chem.
DOI: 10.1002/ejic.200900346
The synthesis of Zr2PTe2 was accomplished by either a solid-state reaction from the elements or by a thermite-type reaction of Zr and Te8O10ACHTUNGRE(PO4)4. Crystals were grown by chemical vapour transport by using
iodine. The compound exhibits metallic behaviour and temperatureindependent Pauli paramagnetism.
Photoswitchable DNA-Binding Ligand
C. Dohno, T. Yamamoto, K. Nakatani*
Photoswitchable Unsymmetrical Ligand for DNA Hetero-Mismatches
Eur. J. Org. Chem.
DOI: 10.1002/ejoc.200900323
We have established an efficient synthetic route for photoswitchable
DNA-binding ligands incorporating two different base-recognition elements. A novel photoswitchable DNA-binding ligand, NCAA (naphthyridine-carbamate-azaquinolone-functionalized azobenzene), recognizes DNA duplexes containing a CAG/CAG sequence, and the binding is reversibly controlled by external light stimuli.
Fullerene Chemistry
J. Iehl, J.-F. Nierengarten*
A Click–Click Approach for the Preparation of Functionalized
[5:1]-Hexaadducts of C60
Successive attachment: The paper describes a C60 hexaadduct bearing
ten azides and two TMS-protected alkyne groups allowing the successive attachment of ten alkyne building blocks (in blue) and two azide
units (in red) via successive click reactions.
Chem. Eur. J.
DOI: 10.1002/chem.200901291
Synthetic Methods
T. T. T. Ho, T. Jacobs, M. A. R. Meier*
A Design-of-Experiments Approach for the Optimization and
Understanding of the Cross-Metathesis Reaction of Methyl Ricinoleate
with Methyl Acrylate
DOI: 10.1002/cssc.200900091
Angew. Chem. Int. Ed. 2009, 48, 5990 – 5991
A design-of-experiments approach for the study of cross-metathesis
reactions with castor-oil-derived renewable resources reveals an interesting temperature response of the studied metathesis catalysts and
provides optimized results for the synthesis of two new renewable
platform chemicals.
2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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