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Eighteenth annual meeting child neurology society.

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Eighteenth Annual Meeting
Child Neurology Society
October 12-14, 1989
San Antonio, Texas
Program
6. Peri-Intraventricular Hemorrhage
Localization, Phenobarbital, and Motor
Abnormalities in Low-Birthweight Children
Wednesday Evening, October 11
Kalpathy S. Krishnamoorthy, Karl C. K. Kuban,
Alan Leviton, Elizabeth R. Brown,
Kathleen R. Sullivan. and Elizabeth N . Allred,
Boston, M A
6:OO Registration
-8:OO
6:OO Early Bird and Junior Member Reception
-8:OO
7. Nasopharyngeal Electrode Recording in
Neonates with Subtle Seizures
August0 Morales, S)rin&eld, IL
Thursday Morning, October 12
7.00 Breakfast
-8:30
7:OO POSTER SESSION I
-1 1:30 Neonatal Neurology, Metabolic Disorders
(Authors present 7:OO-8:30)
1. Anthropometric Measures and Brain
Weight in Relation to Brain Pathology in
Autopsied Very Low Birth Weight Infants
Willzam N . Monte, NigelS. Paneth,
and Raoul D. Rudelli, New York, N Y
2. Effects of Extracorporeal Membrane
Oxygenation on Cerebral Blood Flow in the
Newborn Infant
David H. Beyda, Abraham C. Kuruvilla, and
Allen M . Kaplan, Phoenix, A Z
3. Prognostic Value of Cranial Computed
Tomography in Neonates Undergoing
Extracorporeal Membrane Oxygenation
Suresh Kotagal, Vincent P. Gibbons,
Thomas R. Weber, Robert Connors, and
Barbara Tournour, St Louis, MO
4. Risk of Neurological Sequelae in Patients
Suffering Focal Seizures While on
Extracorporeal Membrane Oxygenation
E. J . Horton, William D. Goldie, C. D. Lew,
A. D.Ramos, K. C. Bui, A. C. G . Platzkw,
M. Garg, D. G . Ashley, and T . A. Nield,
Los Ange1e.r. C A
5. Nephrocalcinosis in Posthemorrhagic
Hydrocephalus Following Treatment with
Furosemide and Acetazolamide
C. Stafstrom, P. Kurtin, and H . Gilmore,
Boston, M A
8. Single-Photon Emission Computed
Tomography Imaging of Neonates with
Arterial Stroke
Robert J , Baumann, Gaty R. Conrad,
U.Yun Ryo, and Charles D. Smith,
Lexington, K Y
9. Relations between Fetal Heart Monitoring
Patterns and the Neonatal Neurological
Evaluation
P. Ellison, M . Sheridan-Pereira, D. MacDonald,
and M . Foster, Denver, CO, and Dublin, Ireland
10. Subcortical Visual Function in the
Newborn
Rmsell D. Snyder, Steven K. Hata,
Benjamin S. Brann, and Rose M . Mills,
Albuquerque, N M , and Rapid City, SD
11. Rapid (Sweep) Visual Evoked Potential
Assessment of Visual Development in
Normal, Premature, and Developmentally
Delayed Infants
Joelle Mast and Jonathan D. Victor,
Neu, York, N Y
12. Hypoxic-Ischemic Cerebral Injury
without Intraventricular Hemorrhage: A
Major Predictor of Outcome in Infants of
1,OOO Grams or Less
Donald F. Macgregor, Elke H . Roland,
Michael F. Whitjield, and Alan Hill,
Vancouver, BC, Canada
13. Protein C Deficiency: A Subpopulation
of Full-Term Infants with Intraventricular
Hemorrhage
Robert J. Gould and Michael Gorqv,
Manhasset. N Y
Copyright 63 1989 by the American Neurological Association 417
14. Vitamin E Pretreatment Reduces
Numbers of Large Endothelial Vacuoles in
Newborn Germinal Matrix after
Hypertension
Jan Goddard-Finegold,Besma I. Adham,
Lloyd H . Michael, and Hal K. Hawkins,
Houston, T X
15. Behavioral Effects of Hypoxia in the
Developing Rat Brain
Morris J . Cohen, Gregory L. Holmes,
Bruce Diamond, and Carmen Cook, Augusta, G A
16. Regional Cerebral Glucose Utilization in
the Immature Rat: Effect of
Hypoxia-Ischemia
Robert C. Vannucci, Melanie A. Christensen, and
Dagmar T . Stein, Hershey, PA
17. Physiological and Neuropathological
Aspects of Hypothermic Circulatory Arrest
in Newborn Dogs
Dennis J . Mujsce, Javad Towjghi, and
Robert C. Vannucci, Hershey, PA
18. Biochemical Effects of Ischemia,
Hypoxemia, and Asphyxia on Selected
Regions of Suckling Rabbit Brain
Robert S. Rust, Jr, St Louis, MO
19. In Vivo Carbon 13 Nuclear Magnetic
Resonance Spectroscopy in Piglet Brain
Donald Younkin and Liz Noyszewski,
Philadelphia, PA
20. Changes in Local Cerebral Protein
Synthesis During Normal Development in
the Cat
John F. Kerrigan, Harry T . Chugani,
David A. Hovda, Jaime R. Villablanca,
Sung-Cheng Huang, Jorge R. Barrio,
Charna H.K. Nissenson, and Michael E. Phelps,
Los Angeles, C A
2 1. Cranial Sonographic Evolution of
Central Nervous System Abnormalities in
Alexander’s Disease
Asma Q.Fischer, David C. Hess, and
Farivar Yaghmai, Augusta, GA
22. Leukodystrophy in GM1 Gangliosidosis
E. Kaye, L. Adelman, J . Alroy, V . Runge,
D. Gelblum, S. S. Raghavan, and J . Thalhammer,
Boston and Waltham, M A
23. P-Ketothiolase Deficiency: New
Approach to Diagnosis and Treatment
May L. Griebel, Diane Gale, Charles R. Roe,
David S. Millington, Michael Stelling, and
Bruce Middleton, Durham, NC, Lexington, K Y ,
and Nottingham, England
24. Hereditary Spastic Paraplegia: Genetic
Patterns and Presenting Features in the
Pediatric Age Range
James J . Riviello, Jr, and Harold G . Marks,
Philadelphia, PA, and Wilmington, DE
418 Annals of Neurology Vol 26 No 3 September 1989
25. Positron-Emission Tomographic
Scanning of Cerebral Metabolism in Classic
Phenylketonuria
P. Kollros, R. J . Allen, B. Shulkin, R. Koeppe,
A. M . Schaefer, B. Giorahi, S. Berent, and
C. Vanderzant, Ann Arbor, MI
26. Isolated 3-Methylcrotonyl Coenzyme A
Carboxylase Deficiency Presenting as a
Reye-like Syndrome
Joyce A. Kobori, Kay Johnston, Lawrence Sweetman,
Kathleen Schmidt, Elaina Jurecki, Barry WOE
Stephen Goodman, and Seymour Packman,
San Francisco, San Diego, and Stanford, CA,
Richmond, V A , and Denver, GO
27. Favorable Clinical Response to Sodium
Benzoate Treatment in Infantile Nonketotic
H yperglycinemia
Vincent P. Gibbons and Suresh KotagaE,
S t Loais, M O
28. Patterns of Visual Memory Dysfunction
in Children with Cystinosis
Doris A. Trauner, Christopher Chase,
Angela Ballantyne, Paula Tallal,
and Jerry Schneider, San Diego, C A
29. Deletion of Mitochondrial DNA in a
Patient with Features of the Kearns-Sayre
and MELAS Syndromes
Mary L. Zupanc, Carlos Moraes, Sara Shanske,
and Salvatore DiMauro, Madison, WI,
and New York, N Y
30. Tryptophan and Serotonin Deficiency in
Hartnup Disease: Long-Term Treatment
with Tryptophan Ethyl Ester
Ian J . Butler and Adam J . Jonas, Houston, TX,
and Torrance, C A
3 1. Neurological Complications in Treated
Galactosemia
Thomas K . Koch, Daniel L. Bluestone.
Kathleen A. Schmidt, Joseph Wagstaff;
Won G. Ng, and Seymour Packman, San Francisco
and Los Angeles, C A
32. The Mutation in a Lebanese Child with
Late-onset GM2-Gangliosidosis Is Different
from that of Jewish Adults with Tay-Sachs
Disease
Rose-May Boustany and Kunihiko Suzuki,
Durham and Chapel Hill, NC
33. Clinical, Laboratory, and MRI Findings
in 17 Patients with the Diagnosis of
Pelizaeus-Merzbacher Disease: MRI Findings
in Obligate Carriers
Marianne B. Larsen and Sharon E. Byrd,
Chicago, 1L
34. Free Radical Scavenging Enzyme
Activities in Alper Disease
Paul Maartens, Eric Weisman, and
C. E. Pippenger, Mobile, AL, and CleveLand, OH
8:30 Welcome and Introduction
-8:45
8:45 Bernard Sachs Lecture
-9:30 Mitochondrial Encephalomyopathies in
Childhood
Salvatore Di Mauro, New York, NY
9:3 0 SYMPOSIUM
-1 1:30 New Concepts in Epilepsy
Moderator: Richard Young, New Haven, CT
Seizures and Epilepsy in Children: Frequency
and Prognosis
W. Allen Hauser, New York, N Y
Controversies in the Treatment of Epilepsy
Peter Camfzeld, UaliJax, Nova Scotia
Seizures and Selective Brain Damage
Robert Sloviter, New York, N Y
Physiological and Metabolic Changes During
Seizures
Richard Young, New Haven, C T
1130 First Business Meeting
-12:30
12:30 Lunch
-2:oo
39. Selective Dorsal Rhizotomy: Selection
and Outcome after Surgery and
Rehabilitation in 38 Patients
Rick Abbott, Sandra L. Forem, Marjorie Johann,
Joan T . Gold, David Quartermain, and
Fred J . Epstein, New York, N Y
40. Rate of Taper of Antiepileptic Drugs
and the Risk of Seizure Recurrence
Michael B. Tennison, Robert S. Greenwood,
Darrell V . Lewis, and Susan E. Benoit,
Chapel Hill and Durham, NC
41. Dietary Erucic Acid Therapy for
Adrenoleukodystrop hy
W. B. Rizzo, R. T . Leshner, A. Odane,
A. L. Dammann, D. A. Craft, S. S. Jennings,
R. Jaitly, S.Davis, and J . A. Sgro,
Richmond, V A , and Sacramento, C A
42. Intermittent Oral Zidovudine Therapy
in Pediatric AIDS
May L. Griebel, Karen J . O’Donnell,
Ross E. McKinney, Catherine Wigert, and
Stanley Wehn, Durham, NC
2:OO PLATFORM SESSION I1
-4:OO Regulation of Cerebral Blood Flow,
Neurobiology
Moderators: Faye Silverstein, Ann Arbor, MI,
and Michael Pranzatelli, New York, NY
(Platform Sessions I and I1 run concurrently)
Thursday Afternoon
43. Cerebral Blood Flow during
2:OO PLATFORM SESSION I
-4:OO Clinical Studies in Pediatric Neurology
Moderators: Ruth Nass, New York, NY, and
Deborah Hirtz, Bethesda, MD
(Platform Sessions I and I1 run concurrently)
35. Neurological Findings and Brain Death
Determination in Twelve Liveborn
Anencephalic Infants
Stephen tlrhwal, Sanford Schneider,
Lawrence G. Tomasi, and Joyce L. Peabody,
Loma Linda, C A
36. Metabolic Alterations in the Dorsal
Prefrontal Cortex of Autistic Patients with
Normal IQ
Nancy J . Minshew, Jay W . Pettegrew,
James B. Payton, and Kanagasabi Fanchalingam,
Pittsburgh, PA
Hyperventilation with and without
Subsequent Barbiturate Therapy during
Intracranial Hypertension
Penny T . Louis,Jan Goddard-Finegold,
Johnny R. Griggs, Fernando Stein,
John P. Laurent, and Mavvin A. Fishman,
Houston, T X
44. Cerebrovascular Abnormalities in
Pediatric Stroke: Diagnosis Using Magnetic
Resonance Angiography
Max Wiznitzer and ThomasJ . Masaryk,
Cleveland, OH
45. Cerebral Blood Flow and Metabolism Is
Uncoupled in Infants with Meningitis
David H. Bey& and Allen M . Kaplan,
Phoenix, A Z
46. Cerebral Blood Flow and COz Reactivity
37. Monoamine Oxidase in Human Disease
K. Sims, A. delachapelle, L. Ozelius, R. Norio,
E. Sankila, J . Gusella, D. Murphy, and
X . 0. Breakefeld, Waltham and Boston, M A ,
Helsinki, Finland, and Bethesda, M D
in Children with Bacterial Meningitis
Stephen Asbual, Wawen A . Stringer,
Lawrence G . Tomasi, Sanford Schneider,
Joseph R. Thompson, and Ron M . Perkin,
Loma Linda, C A
38. Evidence of Developmental Brain
Plasticity Detected with Positron Emission
Tomography
Hamy T . Chugani, Michael E. Phelps, and
John C. Mazziotta, Los Angeles, C A
47. Astrocytes Induce Dendritic
Development in Cultured Sympathetic
Neurons
M . I. Johnson, D. Higgins, and M . D. Ard,
St Louis, MO, Buflalo, N Y , and Jackson, MS
Program and Abstracts, Child Neurology Society 419
48. Evidence That Postnatal Development of
the Mouse Olfactory Bulb Occurs by
Gradual Addition of Newly Constructed
Neural Elements
S. L. Pomeroy, A.4. LaMantia, and D . Purves,
S t Louis, MO
49. Induction of Nerve Growth Factor I-A, a
Neuronal Zinc Finger Transcription Factor,
After Seizures
Kenneth J . Mack, Mark Day, David 1. Gottlieb,
and Jeffrey Milbrandt, St Louis, MO
50. Neuronal and Glial Cytoskeletal Protein
Metabolism in Quaking Mice
Michael J . Noetzel, S t Louis, MO
2:OO POSTER SESSION I1
-5 :30 Neurobiology, Neuromuscular Disorders
(Authors present 400-5:30)
5 1 , Effects of Excitatory Neurotransmitters
and Na+ Channel Toxins on Wobbler Mouse
Spinal Cord Cell Excitability
Raul N. Mundler, Lisa Sornosa, Lany C. Seamer,
and David Whitling, Albuquerque, NM
52. “Physiological” Glutamine Currents Are
Attributable to Residual Glutamate
Kelvin A . Yamada and Steven M . Rothman,
St Louis, MO
53. Quantitative Physiological
Characterization of a Quinoxalinedione
Non-NMDA Receptor Antagonist
Kelvin A. Yamada,Janet M . Dubinsky, and
Steven M . Rothman, St Louis, MO
54. Calcium-Dependent Regulation of
N-Methyl-D-Aspartate Receptors in Rat
Hippocampal Neurons
Gary D. Clark, David B . CliRord, and
Charles F. Zorumki, St Louis, MO
5 5 . Decreases in Aspartate and Increases in
GABA andlor Glutamine in Developing
Mouse Brain after Treatment with Three
Vastly Different AnticonvulsantsBromides, Valproate, and Ketone Bodies
Jean Holmach Thurston, Robert C. Woody,
and Richard E. Hauhart, S t Louis, MO
56. Influence of Hypoglycemia on Striatal
Extracellular Fluid Levels of Neuroactive
Amino Acids in Perinatal Rats: An In Vivo
Microdialysis Study
Jennifer Simpson, Kevin Gordon, and
Faye S . Silverstein, Ann Arbor, MI
57. Alterations in Excitatory Amino Acid
and Gamma-Aminobutyric Acid Receptor
Binding in Excised Hippocampus from
Patients with Temporal Lobe Epilepsy
E. A. Garofalo,J . W. McDonald, J . C. Sackellares,
T. Hood, B. W . Khald, P. E. McKeever,
S. Gilman,J . Troncoso, and M. V .Johnston,
A n n Arbor, MI, and Baltimore, M D
420 Annals of Neurology Vol 26 No 3 September 1989
58. Effect of Neural Transplantation on
Seizures in the Developing Brain: A Study
Using the Kainic Acid Model of Epilepsy
Gregoy L. Holmes, James L. Thompson,
Kyoon Huh, Frank G. Carl, Pamela S. Gabriel,
Colleen A. Holmes, Michelle Edwards, and
Martha Hagan, Boston, M A , and Augusta, GA
59. The Quisqualate Analogue a-Amino-3Hydroxy-5-MethyI-4-IsoxazoleProprionate
Is Neurotoxic to Neonatal Rat Striatum
Donna M . Perriero, Roger P. Simon, and
Hernani Q. Soberano, San Francisco, C A
60. Neuropathological Effects of Glutamate,
Quisqualate, and N-methyl-D-aspartate in
Neonatal Brain
Richard S . K. Young, WilliamJ . Aquila,
Lori Steinberg, and Johnnie Yates,
New Haven, C T
61. A Membrane-Associated Factor
Influences Central Cholinergic Neuron
Development
David N. Hammond, Hen y J . Lee, and
Bruce H. Wainer, Chicago, I L
62. Cyclic Adenosine Monophosphate
Inhibits Guanine Nucleotide-Dependent
Stimulation of Inositol Phosphates in
Astrocytes
Patricia L. Robertson, George R. Bruno, and
Subhash C. Datta, A n n Arbor, MI
63. Tourette Syndrome: A Neurochemical
Analysis of Cortical Brain Regions
Harvey S . Singer, In-Hei Hahn, Eric Nelson, and
Timothy Morun, Baltimore, M D
64.Hyperendorphinism: Results and
Treatment in Movement Disorders
Edwin C. Myer, Hem L. Tripathi, and
William L. Dewey,Richmond, V A
65. Corticotropin-releasing Hormone:
Prenatal and Postnatal Gene Expression in
the Developing Rat Hypothalamus
Tallie Z. Baram and Linda Schultz,
Los Angeles, C A
66. Somatostatin Transgenic Mice: A Model
of Altered Neuropeptide Expression during
Development
Stephen L. Kinsman, Jean Bennett, Bruce O’Hara,
Roger Rewes, John Gearhart, and
M a y L. Oster-Granite, Baltimore, M D
67. Lineage of Motoneurons in Chick Spinal
Cord Studied with a Retrovital Marker
Steven M . Leber, S . Marc Breedlove,
and Joshua R. Sanes, St Louis, MO
68. Molecular Cloning and Analysis of the
Human Myelin P2 Protein Gene
Vinodh Narayanan and Gihan Tennekoon,
Baltimore, M D
69. The Role of Plasmapheresis in Childhood
Guillain-Barre Syndrome
Mark A. Epstein and John T. Sladky,
Philadelphia, P A
70. Beneficial Effect of High-Dose
Intravenous Serum Gamma Globulin in
Severe Guillain-Barre Syndrome
Eli Shahar, E. Gordon Murphy, and
Chaim M. Roifmran, Toronto, Ontario, Canada
71. The Use of Plasmapheresis in the
Management of Guillain-Barre Syndrome in
Pediatric Patients
Nancy Niparko, William D. GoMie,
Wendy Mitchell, Allen Lipsey, S. Robert Snodgrass,
and Lawrence Fishman, Los Angeles, C A
72. Floppy Infant Syndrome with
“Congenital Infantile Polymyositis”
Samuel M . Chou and Janet M . Miles,
Cleveland, OH
73. Relapse of Infant Botulism
Tracy A. Glauser, H e n y C. Maguire, and
John T . Sladky, Philadelphia, PA
74. Upper Brachial Plexus Birth Injuries: A
Surgical Approach
Rita T. Lee, John P. Laurent, Julie T . Parke,
Saleh Shenaq, and Itzel Solzs, Houston, T X
75. Acute Severe Combined Demyelination
Rami Amit, Benjamin Glick, Yakov Itzchak,
Yawn Dgani, and Shirley Meyer, Beer-Sheba,
Jerusalem, and Tel-Hashomer, Israel
76. Studies of Fasting Adaptation Yield
Further Evidence of a Defect of Ketone
Utilization in Spinal Muscular Atrophy
George Fidone, Damell Crisp, and Charles R. Roe,
Temple, T X , and Durham, NC
82. A Monozygotic Female Twin Expressing
Delayed Motor Development: Molecular
Analysis
J . Cook, N. Schneider, E. Hoffman,J . Cortadu,
I. Mihark, K . Katz, and S. Richards, Dallas, T X ,
and Boston, M A
83. Lumbosacral Plexus Neuropathy of
Childhood
Gavin Awerbuch, Jeflrey R. Levin,
Edward Dabrowski, and Michael A. hrigro,
Detroit, MI
84. Beevor’s Sign in Childhood
Facioscapulohumeral Dystrophy
Gavin Awerbuch, JeffveyR. Levin, and
Michael A. Nigro, Detroit, M I
6:OO ABBOTT SYMPOSIUM
-1O:OO Juvenile Myoclonic Epilepsy
Juvenile Myoclonic Epilepsy: Clinical
Characteristics of a Primary Generalized
Epilepsy
W. Edwin Dodson, St Louis, MO
Genetics of Juvenile Myoclonic Epilepsy
Antonio V. Delgado-Escueta, Los Angeles, C A
Treatment of Juvenile Myoclonic Epilepsy
J . KifFn Peny, Winston-Salem, NC
77. Neurosonography in the Evaluation of
the Hypotonic Infant
Asma Q. Fischer, Patricia L. Hartlage,
Sharon Stephens,Jill Trefz, and Carmen Cook,
Augusta, GA
Panel Discussion
Moderator: John M. Pellock, Richmond, VA
78. Acute Inflammatory Demyelinating
Polyradiculoneuropathy following
Immunization with Hernophihs InfEIcenzae
Type b Conjugate Vaccine
0. F. DCruz, E. Shapiro, K . Spiegelman,
B. 0. Khatri, and W. B. Dobyns, Milwaukee, WI,
New Haven, C T , and East Hartford, CT
Friday Morning, October 13
79. Critical Illness Polyneuropathy: A
Reversible Cause of Paralysis in Asthmatic
Children
Keith J. Goulden,Joseph M . Dooley, Sharon Peters,
and Gabriel M . Ronen, St John’s, Newfoundland,
and Halifax, Nova Scotia, Canada
80. Navajo Neuropathy with
Encephalomyelopathy: Clinical Features
Russell D. Snyder, Rosalyn Singleton,
Steven D. Helgerson, and Stanley D. Johnsen,
Albuquerque, N M , and Phoenix and Tucson, A Z
81. Ultrastructural Evidence of Myofiber
Atrophy Distinguishes Benign Congenital
Fiber Type Disproportion from Progressive
Denervating Conditions
E. L. Zalneraitis, M . L. Grunnet, and
B. S. Russman, Farmington, C T
7.QO POSTER SESSION I11
-1I:30 Neuroimaging, Pharmacology,
Neuro-oncology
(Authors present 7:OO-8:30)
85. Transcranial Doppler: A Noninvasive
Method to Monitor Hydrocephalus
Asma Q. Fischer, Alexis Norelle,
and Ann M . Flanney, Augusta, G A
86. Neuroimaging Studies in Children with
Human Immunodeficiency Virus Type 1
Infection
Sansnee Chatkupt, Mark Mintz, Leon G. Epstein,
Daksha Bhansali, and M . Richard Koenigsberger,
Newarh, NJ
87. Magnetic Resonance Imaging of Parents
of Children with Tuberous Sclerosis
E. S. Roach, J e f f e yKerr, and D. W . Laster,
Dallas, T X , and Winston-Salem, NC
Program and Abstracts, Child Neurology Society 421
88. Quantitative Morphometric Analysis of
33. Nifedipine Prophylaxis of Migraines in
Brain Growth Using Magnetic Resonance
Imaging
John B. Bodensteiner, G. Bradley Schaejer,
James N . Thompson,Jr, Moshen Hamza,
Robert R. Tucker, Warren M a r h , Charles T . Gay,
and Don Wilson, Morgantown, WV,
Oklahoma City and Norman, OK, Los Angeles,
CA, and Fort Worth, T X
Children
Sarah M . Roddy and Dantel W . Giang,
Rochester, NY
89. Normal Relative Areas of the Cerebellar
Vermis: Lobules I Through V, Compared
with VI and VII, and VIII
M . Gingold, J . B. Bodensteiner, G. 8. Scha&er,
J . N . Thompson, R. R. Tucker, and D. Wilson,
Morgantown, WV, and Oklahoma City, OK
90. Cerebral Iophetamine-Single Photon
Emission Computed Tomographic Scan:
Analysis of 100 Cases
J . R. Flamini, R . J . Konkol, R. G . Wells, and
J . R. Sty, Milwaukee, WI
91. Iodine 123 Iodoamphetamine
Single-Photon Emission Computed
Tomography Brain Imaging in a Child with
Alternating Hemiplegia
Mary L. Zupanc, Jeff A. Dobkin, and
Scott B. Perlman, Madison, WI
92. Parenchymal and Vascular Magnetic
Resonance Imaging of the Brain after
Extracorporeal Membrane Oxygenation
Max Wiznitzer, Thomas J . Masayk,
Jonathan Lewin, Eileen K. Stork, and
Michele Walsh, Cleveland, OH
93. The Use of Magnetic Resonance
Imaging with Magnetic Resonance
Spectroscopy in the Study of
Medulloblastoma
H. T . Whelan, D. Strother, and
S. Li, Milwaukee, WI
94. Exacerbation of Benign Neonatal Sleep
Myoclonus by Benzodiazepines
James D. Reggin and M a y I . Johnson,
St Louis, MO
95. Valproate-Induced Mitochondrial
Encephalopathy with Ketosis and Adipic
Aciduria
Timothy P. Bohan, WilliamJ . Triggs,
L. James Willmore, and Shen-nan Lin,
Houston, T X
96. Reversible Myopathy Due to Labetalol
J . Willis,A. Tilton, J . Harkin, and F . Boineau,
New Orleans, LA
97. Control of Valproate-Induced
Hepatotoxicity with Carnitine
Carol K. Vance, W. Hugh Vance,
Sman C. Winter, Gnegorz Opala, and
Amy Szabo, Fresno, C A
98. Induction of Omega-Oxidation by
Aspirin
Ramendra K. Kundu and James H. Tonsgard,
Chicago, I L
422
Annals of Neurology Vol 26 No 3 September 1989
100. Theophylline-Induced Seizures
H . U . Parekh, D. W. Dunn, and V . Ackerman,
Indianapolis, IN
101. Allergic Rash Due to Antiepileptic
Drugs: Clinical Features and Management
J . T . Pelekanos, P. R. Camfield, C. Camfield, and
K. Gordon, Halifax, Nova Scotia
102. Thrombocytopenia Associated with
Valproic Acid That Requires Platelet
Transfusions
Raymond D. Cheng, Michael H. Kohrman,
Susan L. Kerr, Patricia K. Duffner, and
Michael E. Cohen, Bsrffalo, N Y
103. The Role of Amantadine Hydrochloride
in the Treatment of Posttraumatic Ataxia
Edward Dabrowski and Michael A. Nigro,
Detroit, MI
104. Fulminant Hepatorenal Failure in Two
Patients Receiving Carbamazepine
Jerome V. Murphy, Charles C. Roberts, and
C. B. Prancisco, Kansas City, KS
105. Retinal Defects in Cocaine-exposed
Infants
Donna M. Ferriero, Joyce A. Kobori,
William V. Good, and Mahin Golabi,
San Francisco, C A
106. Cocaine as a Teratogen: A Controlled
Retrospective Review
Joelle Mast, Carmela Carpanzano, and
Linda Hier, New York, NY
107. Oligodendroglioma Masquerading as
Arteriovenous Malformation: A Potentially
Curable Cause of Intractable Seizures
Andrew K. Hodson, William R. Turk,
Gary L. Wismer, and Mary K. Clancy,
Jacksomille, FL
108. Preradiation Chemotherapy in the
Treatment of Infant Brain Tumors
Jack S. Jacobs, Russell W . Walker,
Mark T . Jennings, and Mary C. McElwain,
New York, N Y
109. "Poor-Risk" Medulloblastoma:
Improved Three-Year Disease-Free Survival
After Treatment with Chemotherapy
Roger J . Packer, Leslie N . Sutton,
Audrey E. Evans, Giulio D'Angio,
Brace H . Cohen,Jonathan Finlay, and Luis Schut,
Philadelphia, PA
110. Immunohistological Profile of
Childhood Primitive Neuroectodermal
Tumorshiedulloblastoma Using a Panel of
Monoclonal Antibodies
R. J . Packer, W . M . Molenaar, D . Jansson,
V . E. Gould, L. B. Rorke, V . M . Y . Lee.
W. W. Franki, and J . Q. Tmjanowski,
Philadelphia, PA
11 1. Late-onset Globoid Cell
Leukodystrophy Mimicking an Infiltrating
Glioma
Mark A. Epstein, John T. Sladky, Lucy B. Rorke,
and Robert A. Zimmeman, Philadelphia, PA
112. The Treatment of Choroid Plexus
Carcinoma in Infancy with Chemotherapy
Patricia K . Duffner, Michael E. Cohen,
Marc Horowitz, Larry Kun, Peter C. Burger,
Richard Kadota, Leticia Vakaez, Peter Phillips,
and Jeffrq Krischer, Buffalo, N Y , and Dayton,
OH
113. Chordomas in Children: Fractionated
Proton Radiation Therapy
Elizabeth C. Dooling, John R. Munzenrider, and
Barry E. Kosofsky, Boston, M A
114. Choroid Plexus Carcinoma: Responses
to Chemotherapy Alone in Newly Diagnosed
Young Children
Jeffrg C . Allen, JeffrevWisoff;Jennsfr Pierce, and
Lawrence Helson, Albany and Valhalla, N Y
11 5. Morphometric Analysis of Central
Nervous System Neoplasms
Pauline A. Fdipek, David N . Kennedy, and
Verne S. Caviness,Jr, Boston, M A
116. Stroke as a Late Sequela of Cranial
Irradiation for Childhood Brain Tumors
Wendy G. Mitchell, Lawrence S. Fisbman,
Stuart M . Siegel, Paul M. Zeltzer, John H. Miller,
Daljit Soni, and Mawin Nelson, Los Angeles,
CA
117. Selective Activation of P-Glucuronidase
from Neuroblastoma Cells by a Novel
Bleomycin Analogue: A Possible Strategy
for Chemotherapy
Nina Felice Schor, Asish Saha, Robert H. Glew,
and Thomas Lomis, Pittsburgh, PA
118. Targeted Chemotherapy for Neural
Crest Tumors
Nina Felice Schor, Pittsburgh, PA
8:45 Young Investigator Award
-9:30 Scott Pomeroy, St Louis, MO
9:30 SYMPOSIUM
-1 1 :30 Developmental Neurobiology
Moderator: Faye Silverstein, Ann Arbor, MI
Neurotropic Factors and Central Nervous
System Development
William Mobley, San Francisco, C A
Neuron-Glia Interactions
Mary Hatten, New York, N Y
Cellular Basis o f the Blood-Brain Barrier
Gary Goldstein, Baltimore, M D
Development o f the Mammalian Visual System
Carla Shatz, Stanford, C A
11:30 Second Business Meeting
-12~30
12.30 Lunch
-2.60
Friday Afternoon
2.60 PLATFORM SESSION I11
-4.00 Cerebral Metabolism, Epilepsy
Moderators: Richard Young, New Haven, CT,
and Jerome Murphy, Kansas City, MO
(Platform Sessions 111 and IV run concurrently)
119. Determination of Cerebral Metabolic
Rates In Vivo Using Stable Isotopically
Labeled Glucose
E. J . Nwotny, Jr, D. L. Rothman, M . J . Avison,
0. A . C. Petroff, G. L m t o s , J . W. Prichard, and
R. G. Shulman, New Haven, C T
120. The Influence of Growth Retardation
on Perinatal Hypoxic-Ischemic Brain
Damage
William H . Trescher, Ralph A. Lehmun, and
Robert C. Vannucci, Washington DC, and
Hershey, PA
121. Protective Effect of Glucose on
Hypoxic Glial Cell Injury
David J . Callahan, Michael J . Engle, and
Joseph J . Volpe, St Louis, MO
122. y-{3H}-Hydroxybutyrate Binding Sites
in the Genetic Rat Model of Spontaneous
Spike-Wave Discharges
0. Carter Snead, Viviane Hechjer,
Marguerite Vergnes, Christian Marescaux,
and Michel Maitre, Birmingham, AL,
Los Angeles, CA, and Strasbourg, France
123. Technetium HMPAO-SPECT and
High-Resolution MRI in Mesial Temporal
Sclerosis
Daniel L. Bluestone, Bamy L. Engelstad,
Nicholas M. Barbaro, and Kenneth D. Laxer,
San Francisco, C A
124. Clinical Manifestations of Complex
Partial Seizures of Temporal Lobe Origin in
Childhood
Prasanna Jayakar, Michael S. Duchowny,
Jerome S. Hailer, TrevorJ . Resnick,
and Luis A. Alvarez, Miami, FL
125. Prospective Evaluation of Seizures
Following Bacterial Meningitis
S . L. Pomeroy, S. J . Holmes, P. R. Dodge, and
R. D . Feigin, St Louis, MO, and Houston, T X
126. Why Children with Epilepsy Do Poorly
in School
Wendy G. Mitchell, Hang Lee, John M . Chavez,
and Bianca L. Guzman, Los Angeles, C A
Program and Abstracts, Child Neurology Society 423
2.QO PLATFORM SESSION IV
-4:OO Clinical Studies in Pediatric Neurology
Moderators: Bennett Shaywitz, New Haven,
CT, and Sakkubai Naidu, Baltimore, MD
(Platform Sessions 111 and IV run concurrently)
127. Sensitivity of DNA and Dystrophin
Testing in Patients with DuchennelBecker
Muscular Dystrophy
L. Specht, F. Shapiro, A. Beggs, E . Hoffman,
and L. Kunkel, Boston, M A
128, Peripheral Neuropathy and Ataxia: A
Uniquely Benign Clinical Presentation of a
Panperoxisomal Syndrome
Mia Madollin, Ann Moser, and
Darryl C. De Viva, New York, N Y
129. Familial X-Linked Myalgia and
Cramps: A Nonprogressive Myopathy
Associated with a Deletion in the
Dystrophin Gene
S. M. Gospe,Jr, R. P . Luzaro, N . S. Lava,
D . M . Grootscholten, M . 0. Scott, and
K. H . Fischbeck, Sacramento, CA, Albany, N Y ,
Philadelphia, PA, and Leiden, The Netherlands
130. Molecular Diagnosis of Duchenne
Muscular Dystrophy
Bruce R. Kor- Pamela P . Hawley, Jennifer Kasper,
and Uma Tantravahi, Boston, M A
131. Girls with Autistic Behavior
Roberto F . Tuchman, Isabelle Rapin, and
Shlomo Shinnar, Bronx. N Y
132. Altered Neurochemical Markers in Rett
Syndrome
Gary L. W e n t Sakkubai Naidu, and Hugo Moser,
Baltimore, M D
133. Acute Disseminated Encephalomyelitis
and Childhood Multiple Sclerosis
Robert S. Rust, Jan Matheson, Arthur L. Prensky,
John S. Trotter, and W . Edwin Dodson, S t Louis,
MO
134. Neuronal Ceroid Lipofuscinosis:
Clinical and Pathological Characteristics in a
Review of 262 Cases
Omar F. Patxot, Krystyna E . Wdsniwski,
Tetsuo Kitaguchi, Paul Dyken, Michel Phildppart,
and Edwin H . Kolodny, Staten Island, N Y ,
Mobile, AL, LOJAngeles, CA, and Boston, M A
2:OO POSTER SESSION IV
-5:30 Epilepsy, CNS Inflammation
(Authors present 4:OO-5;30)
135. Follow-up Study of Intractable Seizures
in Childhood
Peter R. Huttenlocher and Ronald J . Hapke,
Chicago, IL
136. Generalized Tonic-Clonic and
Secondarily Generalized Seizures: Prediction
of Remission During Childhood
Carol Camfield, Peter Camfield, and Joseph Dooley,
Halifax, Nova Scotia
424 Annals of Neurology Vol 26 No 3 September 1989
137. Carnitine Reduction and
Anticonvulsants in Children
Stephen R. Bates and George Hug,
Little Rock, AR, and Cincinnati, OH
138. Recurrence Risk Following Febrile
Status Epilepticus
Joseph Maytal and Shlomo Shinnar, Bronx, N Y
139. Subpial Cortical Transection in
Landau-Kleffner Syndrome
R. Andrews, F. Morrell, and W . W . Whisler,
Minneapolis, M N , and Chicago, IL
140. Hemispheric Electroencephalographic
Asymmetries During Sleep in Newborn
Infants
Jean Hayward and Robert Clancy,
Philadelphia, PA
141. Hemihypsarrhythmia: Presenting
Features, Etiological Factors, and Outcome
C. Stajjtrom, G. B. Mannheim, D. Marks,
R. Schiffmann, and G . Holmes, Boston, M A , and
Jerusalem, lsrael
142. Relationship of Hypsarrhythmia and
Modified Hypsarrhythmia to Developmental
Outcome
Glenn B. Mannherm, Carl Stafstrom,
David A. Marh, Rafael Schdffmann, and
Gregory L. Holmes, Boston, MA,
and Jerusalem, Israel
143. Unusual Variants of Infantile Spasms
Jane F. Donat and Francis S. Wright,
Columbus, OH
144. Apparent Synergism Between Valproic
Acid and Clonazepam in the Treatment of
Infantile Spasms
Warren Lo,Jane Donat, and Fruncis Wright,
Columbus, OH
145. Alteration of Blood-Brain Barrier
Permeability in Bacterial Cerebritis
Warren D. Lo and David McNeely, Columbus,
OH
146. Ocular Compression Reapplied
Jerome S. Haller, Michael S. Duchowny, and
Prasanna Jayakar, Miami, FL
147. Flexible Epidural Peg Electrodes for
Chronic Electroencephalographic
Recording
Elaine Wyllie, Richard Burgess, h a m Awad,
Gene Barnett, and Hans Lcders, Cleveland, OH
148. Hereditary Quivering Chin and REM
Behavioral Disorder
Michael E. Blaw, Robert F. Leroji,
Joel B. Steinberg, and John Herman, Dallas, T X
149. A Characteristic
Electroencephalographic Pattern in Infants
with Bronchopulmonary Dysplasia and Its
Prognostic Implications
Jin S. Hahn and Barry R. Tharp, Stanford, C A
150. The Inappropriate Treatment of
Children Who Have Nonepileptic Events
and Generalized EEG Discharges
Fereydoun Dehkharghani, Iftekhar Ahmed, and
Jerome V . Murphy, Kansas City, MO
151. Hypocarnitinemia and the Ketogenic
Diet
S. Lane Rutledge, Stephen L. Kinsmn,
Michael T . Geraghty, Eileen P. G . Vining, and
George Thomas, Baltimore, M D
152. Intravenous Diazepam Administration
by Paramedics in the Treatment of Status
Epilepticus in Children
Stwen A. Phillips and Robin J . Shanahan,
Stanjbd and Oakland, C A
153. Bromide Therapy for Pediatric Seizure
Disorders Intractable to Other
Anticonvulsants
Robert C . Woody and S. Mark Laney,
Baltimore, M D , and Rochester, M N
154. Management of Febrile Seizures:
Questionnaire Survey
J . Gordon Millichap, John L. Hennessy, and
Gordon T . Millichap, Springfield, IL
155. Adenosine Receptor Activation Induces
a Rapid Increase in C-fos, but not C-jun,
Expression in Neuron-Glia Hybrids and
Fibroblasts
R. M . Gubits,J . B. Wollack, El. Y u , and
W . K. Liu, New York, N Y
156. Neurotransmitter Receptors on Human
Neural Crest Tumors: A New Hypothesis
for the Opsoclonus-Myoclonus Syndrome
Michael R. Pranzatelli, Joanne Balletti, and
Mark Levy, New York, N Y
157. Bivalent Analogs of Adenosine:
New Agents Active at the Adenosine
Receptor
Jan B. Wollack, New York, N Y
158. Binaural Effects in Brainstem
Auditory Evoked Potentials of Jaundiced
Rats
Steven M . Shapiro, Richmond, V A
159. Parainfectious Encephalopathies and
Encephalitis in Children
Nancy A. Niparko and Wendy G . Mitchell,
Los Angeles, C A
160. Interferon Treatment of Experimental
Acute Viral Encephalitis
Alan R. Seay, Denver, CO
163. Pattern of Neurological Abnormalities
in Infants at Risk of Developing AIDS
Joseph C. Marcus, Carolyn A. Butler,
Joan H. Nittelman, Herman Mendez,
James J . Goedert, Ann Willoughby, and
Sheldon Landesman, Brooklyn. N Y . and
Bethesda, M D
164. Absence of an AIDS-related Peripheral
Neuropathy in Children and Young Adult
Hemophiliacs
Thomas K. Koch, Marion A. Koevper,
Ann M. Wesley, Edwin M. Lewis,
Peggy S. Weintrub, and Dale E. Bredesen,
San Francisco, C A
165. Cerebral Blood Flow and Oxygen
Metabolism in Severe Bacterial Meningitis
Mark G. Goettrng and Gregory Preston,
Detroit, MI
166. A New Concept for the Symptomatic
Type of Infantile Spasms and Early Infantile
Epileptic Encephalopathy Using Positron
Emission Tomography
Mikio Hiraiwa, Noriaki Funamoto,
Chizuru Nonaka, Mikiko Mishima, Toshiaki Abe,
and Masaaki Iio, Tokyo, Japan
167. Ferritin Levels in Pyogenic
MeningitisNentriculitis
Richard J . Katnik, Columbia, MO
168. Hemorrhagic Shock and
Encephalopathy: Clinical Features of a
Catastrophic Syndrome in Infants
Enrique Chaves-Carballo, Norfolk, V A
Saturday Morning, October 14
7.30 POSTER SESSION V
-11:30 Stroke, Behavioral Neurology,
Developmental Disorders
(Authors present 7 3 0 - W 0 )
169. Isolated Central Nervous System
Angiopathy Associated with Busulfan
Edwin L. Zalneraitis, Margaret L. Grunnet,
John J . Quinn, and Jonathan Kramer,
Farmington, CT
170. Ischemic Stroke in Childhood: A
Five-year Review of Twenty-eight Cases
Gavin Awerbuch, Jejfrey R. Levin, Rashmi Gupta,
and Michael A. Nigro, Detroit, MI
161. Neurological Manifestations of Lyme
Disease in Children
Dorothy M . Pietrucha, Neptune, NJ
171. Isolated Angiitis of the Central
Nervous System in Children
Jeffrey R. Levin, Gavin Awerbuch,
Michael A. Nigro, and Louis Rentz, Detroit, MI
162. Neurological Involvement in Pediatric
Lyme Disease
A. L. Belman, P. K. Coyle, S. E. Schutzer,
M . Engel, and R. Dattwyler, Stony Brook, N Y ,
Newark, ILY,and Stanford, CT
172. Happy Puppet Syndrome of Angelman:
Clinical, Anatomical, and Physiological
Correlates
J . R. Levin, G. I. Awerbuch, L. Kuhns,
M . Galloway, and M . A. Nigro, Detroit, MI
Program and Abstracts, Child Neurology Society 425
173. Idiopathic Childhood Stroke Is
Associated with Human Leukocyte Antigen
B5 1
Mark Mintz, Leon G. Epstein, and
M . Richard Koenigsberger, Newark, NJ
185. The IQ-Syndrome: Neurological,
Behavioral, and Linguistic Uniqueness
Keiko Murayama, Robert S. Greenwood,
Arthur S. Aylsworth, and Kathleen W . Rao,
Chapel Hill, NC
174. Neurological Complications of
Lymphoproliferative Disorders in Bone
Marrow Transplant Recipients
James F. Bale, Jr, Yutaka Sato, and
Michael E. Trigg, Iowa City, IA
186. A Specific Memory Deficit in a Group
of Children with Neurofibromatosis and
Learning Disability
Catherine A. Chapman, Bruce R. Korf; and
David K. Urion, Boston, M A
175. Stroke in Children: A Ten-year
Experience at a Children’s Hospital
Joseph J . Higgins, Lisa A. Kammerman, and
Charles K. Fitz, Washington, DC
187. Expression of a Neural Cell Adhesion
Molecule Serum Fragment Is Depressed in
Autism
Audrius V. Pldoplys, Susan E. Hemmens,
and Ciaran M . Regan, Toronto, Ontario, Canada,
and Be&eld, Dublin, Ireland
176. The Neurological Manifestations of
Phosphoglycerate Kinase Deficiency
Meredith J . Wilson, Marcus R. Vowels,
and Grabame Wise, Randwick, NSW, Australia
177. Hormones and Learning Disabilities:
Incidence in Congenital Adrenal
Hyperplasia
Ruth D. Nass and Susan W . Baker,
New York, N Y
188. The Hippocampus in Autism: Golgi
Analysis
Gerald Raymond, Margaret Bauman,
and Thomas Kemper, Boston, M A
180. Response to Desipramine in Attention
Deficit Hyperactivity Disorder Is Predicted
by Neurological Subtype
Daeid K. Urion,Boston, M A
189. Vascular Complications of
Neurofibromatosis-I
M . G. Chez, A. D. Rothner, and S. Chou,
Cleveland, OH
190. Angelman’s Syndrome in Infancy
Kelvin A. Yamada and Joseph J . Volpe,
St Louis, M O
191. Linkage Localization of
Borjeson-Forssman-LehmannSyndrome to
Distal Xq
Katherine D. Mathews, Holly H. Ardinger,
Darryl Y . Nishimura, and Jeffrey C. Muway,
I m a City, IA
192. P-Amyloid Immunoreactivity in
Hippocampus from Fetal, Neonatal, Infant,
Adolescent, and Adult Down Syndrome
Robert C. Woody, Laura C. Stanley,
Gareth W . Roberts, and Sue T . Gr@n,
Little Rock, AR, and Harrow. IJK
181. Prosodic and Gestural Characteristics
of Developmental Right-Hemisphere
Syndrome
Theodore Sunder and Salvatore DeMarco,
Greenuille, NC
193. Isolated Congenital Malformation of
Hippocampal Formation as a Cause of
Intractable Neonatal Seizures
E. Bevy-Kravis, P. R. Huttenlocher, and
R. L. Wollmann, Chicago, IL
182. Morphometry of the Cerebral
Hemispheres in Developmental Dysphasia
Ton J . De Grauw, Charles Njiokiktjien,
and Leo M. J . de Sonneuille,
Amsterdam, The Netherlands
183. Relationship of Language Impairment
and Seizures in Children with Verbal
Auditory Agnosia
Susan K. Klein, Roberto F . Tuchman,
and Isabelle Rapin, Bronx, N Y
194. Unexplained Cerebral Palsy:
Dopa-responsive Dystonia?
Torbjoern G. Nygaard, Sandy P. Waran,
and Abe M. Chutorian, New York. N Y , and
Mowistmn, NJ
195. Immunohistochemical Study of
Hemimegalencephaly: Relationship to
Tuberous Sclerosis
Janet M. Miles, Samuel M . Chou, and
Elaine Wyllie, Cleveland, OH
184. Neurological and Neurocognitive
Assessment of Survivors of Orthotopic Liver
Transplantation
Mark A. Epstein, Roger J . Packer,
Jerilynn Radcltjfe, Marianne Buzby,
Robert A. Zimmerman, Robert Lenkinski,
and John B. Watkins, Philadelphia, PA
196. Effect of Naloxone on Breathing, Hand
Movements, and Electroencephalogram
during Wakefulness in Patients with Rett
Syndrome
Daniel G . Glaze, James D. Frost, Jr,
Rebecca J . Schultz, and Alan K. Percy,
Houston, TX
178. Effects of Congenital Left-Hemisphere
Injury on Hemispheric Specialization
During the First Year
Ruth D. Nass, Kristine MacKain, and
John J . Sidtis, New York, N Y
179. A Group of Deaf Children with
Attention Deficit Hyperactivity Disorder
with Good Clinical Response to Desipramine
and Poor Clinical Response to
Methylp henidate
David K. Urion, Boston, M A
426 Annals of Neurology Vol 26 No 3 September 1989
197. Rett Syndrome:
Electroencephalographic and Epileptological
Aspects
S. Naidu* H . W . &loser, and E. Niedermeyw.
Baltimore, M D
198. Atypical Rett Syndrome
Michel Philippart, Lor Angeles, C A
199. Rett Syndrome i n Association with a
Complex Translation Involving
Chromosomes 13, 15, and 18
Maty E. Carlin, J . Fernando, P. Arena, and
Paul S . Ing, Miami, FL, and Omaha, NE
200. Airflow Obstruction in Children with
Rett Syndrome
Peter W . Hiatt, Daniel G . Glaze, and
James D . Frost, Jr, Houston, T X
201. A Kinematic Diagnostic System for
Detecting Movement Disorders in Infants
and Children: Preliminary Report
Elizabeth L. Leonard, Ruth A . Maubcci,
Lynn Eliason, and TheodoreJ . Tarby,
Phoenix, AZ, and Scituate, M A
202. Hydrocephalus Management by
Endoscopy
Kim H . Manwaring, Hal Rekate, and
Allen Kaplan, Phoen tx, AZ
9:OO Hower Award: Presentation and Lecture
-9:45 A Tale of T w o Genes
Manuel Gomez, Rochester, MN
9:30 SYMPOSIUM
-11:30 DPT Immunization and t h e Central Nervous
System
Moderator: Deborah Hirtz, Bethesda, MD
British Experience with DPT Vaccine
Roger Gilliatt, Bethesda, M D
Clinical Evaluation of DPT Encephalopathy
Gerald Fenichel, Nashville, TN
National Childhood Vaccine Injury Act
Cynthia McCormick, Bethesda, M D
Panel Discussion
Moderator: Donald Shields, Los Angeles, CA
11:30 Closing Remarks
-11:45
Abstracts
1. Anthropometric Measures and Brain Weight in
Relation to Brain Pathology in Autopsied Very Low
Birth Weight Infants
Walliam N.Monte, Nigel S . Paneth, and Raoul D . Rudklh',
New York, N Y
We examined anthropometric measures at birth and death in
83 very low birth weight (VLBW) infants (mean birth weight
899 gm, mean gestational age 27.2 wk) derived from a prospective population-based study of neonatal brain hemorrhage in infants under 2,000 gm. At birth, birth weight
(BW), crown-heel length (CHL), and head circumference
(HC) were obtained on all subjects, and at death, these measurements plus fresh brain weight, biparietal diameter, occipitofrontal diameter, frontofontanel diameter, crown-rump
length, knee-ankle length, elbow-wrist length, and foot
length were obtained on 54 to 75 subjects. These measures
were assessed for their relationship to the presence of the
following neuropathological entities: germinal matrix hemorrhage (GMH), intraventricular hemorrhage (IVH), choroid
plexus hemorrhage (CPH), cerebellar hemorrhage (CH), and
white matter necrosis (WMN). Birth anthropometric measurements were not statistically associated with any specific
brain lesion. Brain weight was analyzed controlling for body
weight at death, because the two measures were closely correlated (32). We noted that: (1) brain weight, when controlled for body weight, was not related to the presence of
any specific neuropathological entity; (2) HC at death correlated well with brain weight (.78), but in 58 infants who
died in the first 5 days, change in H C was not associated with
any specific neuropathological entity; (3) infants with WMN
died at significantly ( p < .001) more advanced ages (mean
25.5 days) than did infants without this lesion (mean 2.5
days). These findings fail to confirm the hypotheses of
DeCourten and Rabinowicz (Dev Med Child Neurol 1981;
23:287) and Coulter et al (Pediatr Res 1985;19:1322) that
IVH is related to changes in brain weight postnatally. CPH
was not seen to occur preferentially in larger babies, but
WMN was increasingly likely the longer the baby survived.
2. Effects of Extracorporeal Membrane Oxygenation on
Cerebral Blood Flow in the Newborn Infant
David H . Bqdz, Abraham C. Kuruvilla, and
Allen M . Kapkan, Phoenix, A 2
Extracorporeal membrane oxygenation (ECMO) may adversely influence cerebral blood flow (CBF) because of ligadon of the right carotid artery and internal jugular vein and
institution of nonpulsatile partial cardiopulmonary bypass.
Four newborn infants with a mean birth weight of 3,275 2
880 gm, 1-minute Apgar score of 5.1 2 2.7, and 5-minute
Apgar score of 7.1 -+ 1.4 had serial bedside CBF measurements before, during, and after ECMO, using intravenous
xenon 133 and 2 detectors placed in parallel fashion over
each hemisphere. CBF15 was derived as the mean CBF of
the fast- and slow-clearing compartments. All infants were
conventionally ventilated and hemodynamically stable during
the studies. Cranial ultrasounds before and after ECMO
were normal in all children. All survived neurologically intact. Six-month follow-up revealed normal growth and development.
Program and Abstracts, Child Neurology Society 427
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