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Erratum to УGenome-wide association analysis of age at onset and psychotic symptoms in bipolar disorderФ American Journal of Medical Genetics Part B Neuropsychiatric GeneticsФ April 1; 156(3) 370Ц378.

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ERRATUM
Neuropsychiatric Genetics
Erratum to ‘‘Genome-wide association analysis of age
at onset and psychotic symptoms in bipolar
disorder’’, American Journal of Medical Genetics Part
B: Neuropsychiatric Genetics’’, April 1;
156(3):370–378
The authors have recently discovered an error in analysis that
alters the results of their recently published GWAS of age at onset in
bipolar disorder. Figure 1 and Table II below show the corrected
information. Please note that all results remain statistically nonsignificant and thus the conclusions drawn remain the same.
The results for the analysis of psychotic symptoms were not affected
by this mistake and no other publications were influenced. The
authors sincerely regret this error and apologize for any confusion it
may have caused.
FIG. 1. Manhattan plot for GWA of age at onset of BP. Genome-wide association results for observed and imputed allelic dosages using linear
regression.
Published online in Wiley Online Library
(wileyonlinelibrary.com).
DOI 10.1002/ajmg.b.31228
2011 Wiley-Liss, Inc.
749
750
AMERICAN JOURNAL OF MEDICAL GENETICS PART B
TABLE II. Top Regions in the Analysis of Age at Onset in the GAIN-BP þ BiGS þ German Samplea
GAIN-BP þ
BiGS þ German
SNP
rs455313
rs7623652
rs872303
rs2013725
rs10211220
rs12586412
rs259218
rs10859064
rs2072254
rs6130803
a
Chr
6
3
10
15
2
14
19
12
17
20
Gene
Intergenic
TTMP
CPXM2
Intergenic
ARHGAP15
RGS6
ANKRD27/RGS9BP
Intergenic
RICH2/ARHGAP44
SLPI/MATN4
BP Location
95117275
113321634
125585154
59778185
144131629
72044592
37829965
89771333
12793184
43356516
The most significant SNP per region is listed as a representative SNP.
b is calculated for the rare allele.
N/A ¼ not applicable when the direction of effect is opposite in the two samples.
b
c
bb
1.51
3.99
2.05
3.82
1.63
1.24
1.34
1.21
2.13
2.28
P-value
1.40 107
3.01 106
3.53 106
3.92 106
4.87 106
6.15 106
8.33 106
8.56 106
1.05 105
1.07 105
Replication Sample
bb [PM1]
0.13
0.43
N/A
0.75
0.46
0.04
0.18
0.08
0.01
0.29
P-value
0.64
0.61
N/A
0.44
0.16
0.88
0.52
0.73
0.97
0.61
Meta-Analysis
P-valuec
1.46 104
5.79 104
N/A
N/A
5.33 105
2.13 103
N/A
N/A
N/A
N/A
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156, april, disorder, journal, 370ц378, wide, neuropsychiatry, уgenome, onset, part, associations, psychotic, analysis, symptom, american, age, medical, bipolar, genetics, erratum
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