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Peptides and Proteins. By Shawn Doonan

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radicals, or wish to do so. It can be recommended for final-year degree students and post-graduates working in
the area of free-radical chemistry,
whether their interests are in spectroscopy and structure, in mechanisms, or
in synthesis. For these, the book is an
ideal introduction to the analysis and
understanding of the electronic structure of organic free radicals. It can also
be strongly recommended for chemists
who are not involved in the analysis of
ESR spectra on a daily basis, but who
occasionally meet the problem of identifying organic free radicals.
Hans-Gert Korth
Institut fr Organische Chemie
Universitt Duisburg-Essen (Germany)
Peptides and Proteins
By Shawn Doonan.
Royal Society of
Chemistry, Cambridge 2002.
186 pp., softcover
£ 12.95.—ISBN
0-85404-692-5
Peptides and Proteins is a textbook for
students in their first semester who are
encountering this subject for the first
time. The six chapters cover the basic
principles of peptide and protein structure, chemical synthesis of peptides, protein purification, protein analysis, folding of protein molecules, and structure
simulation. At the beginning of each
chapter is a bold-type list of learning
objectives, which thoroughly covers the
topics treated within, and can be referred to later by the student to test his
or her new knowledge. In addition, the
text is interrupted frequently by colorhighlighted questions; however, the
2470
intended stimulus to thought is rather
blunted by the fact that the answers
are given in the same place. Additional
and background information is presented in boxes that are separated
from the text, so that it is quickly accessible but need not interrupt the reading
flow. More exercise questions are provided at the end of the chapter, and
answers to these are given at the end
of the book. Finally each chapter has a
list of literature references, including
more advanced material for further
reading.
This textbook enables the student to
work through the elementary fundamentals of peptides and proteins without the need for any previous knowledge of the subject. The more complex
problems are presented in a greatly simplified way, as is appropriate for the
intended readership, but sometimes in
ways that could lead to misunderstanding. For example, structural formulas
and abbreviations are sometimes mixed
in the figures, for example in GluCOOH (where the intention was to
emphasize the carboxylic acid moiety
of the glutamic acid side chain), or
where Me is shown instead of CH3 in
structural formulas, a practice that can
be confusing for beginners. All the chapters have a very good didactic structure,
although the connection between individual chapters is often not clearly
brought out. However, the book's most
serious limitation is the very brief
index, which fails to include many of
the words and expressions that students
will have read and worked on in the text.
Therefore, the book cannot be recommended as a collection of methods for
studying peptides and proteins. On the
other hand, it can certainly be recommended as a didactic and well-written
introduction to the subject.
Annette G. Beck-Sickinger
Institut fr Biochemie
Universitt Leipzig (Germany)
DOI: 10.1002/anie.200385020
3 2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
www.angewandte.org
Angew. Chem. Int. Ed. 2004, 43, 2469 – 2470
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