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Head injury. Edited by Paul R. Cooper Baltimore Williams & Wilkins 1982 373 pp illustrated $49

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Morphology of the Rat Brain Ventricles,
Ependyma and Periventricular Structures
Edited by A. Mitro and M . Palkovits
(vol21 of Bibliotheca Anatomica
Edited by W . Lierse)
New York, Karger, 1981
110 pp, illustrated, $58.75
This carefully prepared volume accurately details the
anatomy of the ventricular system and the morphology of its
ependymal surface in the adult male Wistar rat. The first third
of the book is an atlas of the ventricles. Photographs of 10
p n thick Lux01 fast blue-stained sections face corresponding
schematic representations. Sixty-four coronal sections depict
the brain at 300 p m increments from 3 mm rostral to the
bregma to the spinal-medullary junction 15.9 mm posterior
to the bregma. Eight sagittal and eight horizontal serial sections detail the midline ventricular structures and the
mediolateral extent of the ventricles, respectively. Although
this portion of the book is not intended as a stereotaxic atlas,
sufficient detail is given for localization of structures related
to the ventricular system.
The rest of the book gives a light and electron microscopic
analysis of the ependyma bordering (1) the lateral ventricle,
(2) the third ventricle, (3) the cerebral aqueduct and mesencephalic ventricle, and (4)the fourth ventricle and beginning of the central canal. Topographic coordinates, structure
of the ependymal areas, and cell groups composing the ependyma of each location are discussed, as are the anatomical and
physiological relationships between the ependyma and subependymal structures.
A fairly extensive index catalogs subjects (structures)
primarily as they appear in the figures. Because only the page
numbers are given for both text and figure references, finding
the discussion of a particular topic can be tedious.
This work provides an essential text for the neuroscientist
involved in the study of the ependyma and cerebral ventricles.
William T . Talman, M D
Iowa City, IA
Head Injury
Edited by Paul R. Cooper
Baltimore, Williams 6 Wilkins, 1982
373 pp, illustrated, $49.00
During the last 15 years, the advent of computed tomographic scanning and microsurgical techniques has resulted in
improved care of neurosurgical patients. Management of severe head injury has been one of the areas of most conspicuous progress. It is interesting that the improvements in head
injury management have been related primarily not to better
drug therapy or new operative techniques but to improved
understanding of the pathophysiology of head injury.
The widespread use of the Glasgow Coma Score and computed tomographic scanning, begun in the mid-l970s, has
produced a classification system that can delineate distinct
groups of comatose head-injured patients characterized by
mortalities varying from 10 to 84%. Head injury was discovered to be heterogeneous in pathophysiological findings and
outcome. As a result of the recent appreciation of the severe
secondary brain damage caused by elevated intracranial pressure, monitoring of intracranial pressure is now common.
Hypoxia and delayed surgical treatment have been shown to
impair outcome seriously, and emergency services have been
organized to provide prompt care. Care of large numbers of
these critically injured patients in head injury centers has
made possible the development of sophisticated intensive
care techniques, including cerebral blood flow studies, electrophysiological techniques, and improved management of
altered metabolism. There is evidence that extensive research
and the resulting changes in treatment have improved the
outcome in cases of severe head injury over the last 15 years.
This volume comprehensively describes these improvements in our understanding of head injury and relates them
in a practical way to management of the severely headinjured patient. The book fills the need for an up-to-date text
that describes these improvements in care and promotes their
application in the practice of neurology and neurosurgery.
The text contains twenty-four chapters by twenty-five
American authors, each an authority on a specific area of
head injury. The chapters are well illustrated, comprehensive, and highly readable. The subjects are interwoven effectively, with minimal repetition. The book is written for the
physician who cares for the severely head-injured patient and
provides a very practical guide for management as well as a
discussion of its scientific basis. This text should be required
reading for neurosurgeons in training and on the shelf of any
physician who cares for the head-injured patient.
Guy L. Clifton, M D
Houston, T X
Nervous System Toxicology (Target O r g a n
Toxicology Series)
Edited by Clifford L. Mitchell
New York, Raven Press, I982
392 pp, illustrated, $SS.OO
This volume, despite its title, is not intended as a text or
general reference in the field and is not directly relevant to
human neurotoxicology. Its principal focus is early detection
of the effects of toxins on the nervous system. A more appropriate title might have been Experimental Techniques in
Neurotoxicology. Twelve of the eighteen chapters in this
multiauthored volume are concerned with behavioral techniques, and four are devoted to tissue culture, biochemistry,
electrophysiology, and morphology, respectively. Two chapters are clearly out of place in the book: one is a concise
review of metal neuropathology by Krigman, and the other is
Jacob's superb survey of vascular permeability as a determinant of neurotoxicity.
The twelve chapters devoted to behavioral neurotoxicol-
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coope, wilkins, paulo, 1982, william, head, 373, illustrated, edited, injury, baltimore
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