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Iatrogenic amyloidotic apoplexy.

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Amyloidotic Apoplexy
Society for Progressive
Supranuclear Palsy, Inc
Melvyn J. Ball, MD, FRCP(C)
David Saks
The timely warning by Pendlebury and coworkers {I] of
the danger of triggering fatal intracerebral hemorrhage by
thrombolytic therapy with tissue plasminogen activator for
the treatment of acute myocardial infarction was already
drawn to our attention somewhat earlier by our Canadian
colleagues [2], who published the case of a 56-year-old man
dying with multifocal temporoparietal hemorrhages 8 hours
after an intravenous infusion of streptokinase for an acute
myocardial infarction. Both patients had cerebral amyloid angopathy pathologically.
This is to inform you and your physician-readers that there
is a new advocacy and mutual support group in the neurological field.
A small group of patients with progressive supranuclear
palsy (PSP) have banded together to see that research into
this debilitating illness receives more attention by the public
and members of Congress. We feel that as an organized
group, with a membership of representative size, we can penetrate the fund-allocation system of the federal government.
Increased clinical and advanced scientific research into the
cause and cure of PSP may produce medications and treatments that will be new and effective tools in the hands of
neurologists as they care for PSP patients-and replace present helplessness (matched only by the helplessness of the
patients themselves).
Neurologists: please pass this information on to your patients. Please ask them to write to the Society for Progressive
Supranuclear Palsy (SPSP), 2904-B Marnat Road, Baltimore,
MD 21209.
Thank you very much.
Division of Nezlropathology
Oregon Health Sciences University
Portland, OR
1. Pendlebury WW, Iole ED, Tracy RP, Dill BA. lntracerebral hemorrhage related to cerebral amyloid angiopathy and t-PA treatment. Ann Neurol 1991;29:210-213
2. Ramsay DA, Penswick JL, Roberston DM. Facal streprokinaseinduced intracerebral haernorrhage in cerebral amyloid angiopathy. Can J Neurol Sci 1990;17:336-341
Society for Progressive Supranuclear Palsy
Baltimore, M D
Editor’s Note
The report by Ramsay and colleagues appeared the month
after the paper by Pendlebury and coworkers was submitted.
A. K. A.
Annals of Neurology
Vol 30 No 2
August 1991 229
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iatrogenic, amyloidotic, apoplexy
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