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105th Annual Meeting of the
American Neurological Association
September 7-10, 1980
Sheraton Boston Hotel, Boston, MA
5a. Experimental Hyperglycemia and Diabetes
Mellitus Worsen Stroke Outcome
W . Pulsinelli, B. Sigsbee, S. Waldman, D. Rawlinson,
P. Scherer, and F . Plum, New Yovk, N Y
6a. Ischemic Brain Edema Requires Tissue
Necrosis
C . K. Petito, W. A. Pubinelk, G.Jacobson,
and F . P b m , New York, N Y
7a. T h e Role of Hydrocephalus in
Unexplained Late-Life Gait Disorders
C . M . Fisher, Boston, M A
Program
Sunday, September 7
Joint Session with the American EEG Society
1:30 Presidential Symposium: T h e Topography of
-4:30 Cerebral Function
Chairman: Richard N. Harner, Philadelphia, PA
Participants:
Martin Reivich, Cerebral Metabolism as an Index
of Local Brain Function
Norman Geschwind, Cortical Localization of
Altered Behavior
David Ingvar, Delineation of Functional Cortical
Areas by Regional Blood Flow
Richard N . Harner, Computerized EEG
Topography of Focal Cerebral Lesions
6:OO Cocktail party
-8:oo Museum of Fine Arts, Boston
B. Chairman: James A. Ferrendelli, St. Louis, MO
Secretary: Marvin Fishman, Houston, TX
Ib. Delayed High-Iodine-Dose Contrast
Computed Tomography for Cranial Neoplasms
L. Anne Hayman, Robert A. Evans, and Vincent C.
Hinck, Houston, T X
2b. histological Characteristics and Biological
Behavior of Oligodendrogliomas
M. T. Smith, C . L. Ludwig, V . W. Armbmstmacher,
J . M . Henry, and K . M . Earle, Bethesda, M D , and
Washington, DC
3b. Melanotropic Effects of Benzodiazepines:
Correlation with a High-Affinity Receptor
E. Matthew, D . L. Engelhardt, J . D . L s k i n , and
E . A. Zimmerman, New York, N Y
Monday, September 8
Morning Session
9:OO Presidential Address
Peritz Scheinberg, Miami, FL
9:30 Simultaneous Platform Sessions A and B
-12:oo
4b. Prolonged lntracerebral Infection with
Poliovirus in Asymptomatic Mice
James R. Miller; New York, N Y
5b. Focal Cortical Seizures Inhibit Brain
Protein Synthesis
Robert C. Collins, Carolyn B . Smith, and Louis
Sokolofl, St. Louis, MO, and Bethesda, M D
6b. Clinical Aspects of Status Epilepticus in an
Unselected Urban Population
Roger P. Simon and Michael J . Aminoff, San
Francisco, CA
7b. Removal of Sedative Antiepileptic Drugs
from t h e Regimens of Patients with
Intractable Epilepsy
William H. Theodore and Roger J . Porter, Bethesda,
MD
10:30 Coffee Break
-1 I :oo
A. Chairman: Joseph M. Foley, Cleveland, OH
Secretary: John N. Whitaker, Memphis, TN
la. Positron Imaging of the Normal
Brain-Functional Asymmetries
S. Finklestein, N.A . Alpert, R. I € . Acketman,
F . S. Buonanno, J . A. Correia, J . Chang, S. Kulas,
and G. L. Brownell, Boston, M A
2a. Selective Necrosis i n the Central Nervous
System-Histopathological Observations in
the Macaque Monkey following Transient
Focal Cerebral Ischemia
U . DeGirolami, R . M . Crowell, and F. W . Marcoux,
Worcester, Boston, and Burlington, M A
3a. Local Metabolic Responses in Brain
Accompanying Motor Activity
C. Kennedy, M . Miyaoka, S. Suda, K. Macko,
C . Jarvis, M. Mishkin, and L. Sokolofi, Betbesda,
MD
4a. Recovery from Locked-In Syndrome
Elizabeth A . McCusker, Richard A. Rudick, and
Robert C . Griggs, Rochester, N Y
12:OO First Executive Session of Membership
-I :30
1 2 3 0 Poster Session
-1 :30
8. Electrical Kindling of the Amygdala:
Evidence Against a Muscarinic Mechanism
C. G. Wasterlain, V .Jonec, Harris Hubeman, and
Anne M . Morin, Sepulzvda, C A
83
9. Loss of Autoregulation of Cerebral Blood
23. Postictal Pleocytosis
James W . Schmidley and Roger P. Simon, San
Francisco, C A
24. Effect of Chronic Seizures on Religiosity
L. James Willmore, Kenneth M . Heilman, Eileen
Fennell, and Ruth M . Pinnas, Gainesville and
Miami, FL
25. Hysterical “Seizures”-The Use of Saline
Infusion and Suggestion as a Provocative Test
in 41 Cases
Robert J . Cohen and Cavy Suter, Richmond, VA
26. Cataplexy in Variant Forms of
Niemann-Pick Disease
Raymond S. Kandt, Ronald Emerson, and Hugo
Moser, Baltimore, M D
27. Electrophysiological Assessment of Facial
H ypesthesia
J u n Kimura and Thoru Yamada, Iowa City, IA
28. Major Neurological Learning Experiences
Augmented by Matrix Organization: A Rapid
Method of Assessing Qualitative and
Quantitative Aspects of a Training Program
Anthony C. Breuer, Lisa R. Rogers, andJohn P.
Conomy, Cleveland, OH
Flow: An Asset during Single Seizures, a
Liability during Status Epilepticus
Claude G. Wasterlain and Stephen L. Graham,
Sepulveda, C A
10. Electrophysiological Effects of Cyclic
Nucleotides in Brain Tissue in Vitro
J . A. Ferrendelli, A. C. Blank, D. A . Kinrcher- and
E. W . Lothman, St. Louis, MO
11. Electroshock Seizures: Effect on Brain
Adenosine and Its Metabolites
Edward Lewin and Virginia Bleck, Denver, CO
12. Neurotoxicity of a New Chemotherapeutic
Agent, Phosphonoacetyl- 1-Aspartate: Clinical
Observations and a Laboratory Model
R. G. Wiley and R. J . Gralla, New York, N Y
13. Myokymia of Segmental Spinal Cord Origin
Godofredo R. Celis, Roger W . Kula, Mahendra
Somasundaram, Joanna H . Sher, and Henry S.
Schutta, Brooklyn, N Y
14. Phenytoin and the “Safety Margin” of
Neuromuscular Transmission
L. Fernando Franco and Barry W . Festofi, Kansas
City, KS
15. Long-Latency Event-related Potentials in
Normal Aging and Dementia
Karl Syndulko, Edward C. Hansch, Stanley N .
Cohen, James W . Pearce, Barbara Montan, Zw
Goldberg, Wallace W . Tourtellotte, and Alfred R.
Potvin, Los Angeles, CA, and Arlington, T X
16. Focal Epileptogenesis and the Visual
Evoked Response
Arthur D . Rosen and Anne H . Remmes, Stony Brook,
NY
17. A Novel Approach in Detecting Toxic
Axonal Neuropathies: The Brainstem
Somatosensory Evoked Potential
Joseph Arezzo, Herbert Schaumburg, Peter Spencer,
and Herbert G. Vaughan,Jr., Bronx, N Y
18. Binaural Interaction in Human Brainstem
Potentials
Robert A. Levine, Boston, M A
19. A Comparison of Electrical Studies of
Brain Function in Epileptic Patients:
Simultaneous EEG and Positron Emission
Computed Tomography
Jerome Engel, J r , , David E. Kuhl, and Michael E.
Phelps, Los Angeles, C A
20. Neurogenic Pulmonary Edema in
Unexpected, Unexplained Death in Epileptic
Patients
Christopher F. Terrence, G u t t i Rao, and Joshua
Perper, Pittsburgh, PA
2 1. Mechanisms of Neurogenic Pulmonary
Edema following Seizures in Sheep
R. P. Simon, L. L. Bayne, and R. F . Tranbaugh, San
Franci.uo, C A
22. Electroencephalographic Findings during
Cardiac Catheterization
Varun K. Saxena, Michael P. McQuillen, Gregory J .
Hawington, and Michael H . Keelen, Milwaukee, WI
84 Annals of Neurology
Vol 8 No 1 July 1980
Afternoon Session
2:oo Symposium: Surgical Treatment for Epilepsy
-3 :30 Chairman: Robert G. Feldman, Boston, MA
Participants:
Robert Gumnit, Office Evaluation of Candidates
for Temporal Lobectomy
Jerome Engel, Inpatient Evaluation of Candidates
for Temporal Lobectomy
Paul H. Crandall, Temporal Lobectomy:
Technique and Results
Sidney Goldring, Temporal Lobectomy:
Technique and Results
3:30 Coffee Break
4:oo
4.90 Symposium on Cerebrovascular Disease, in
-5 :3 0 Honor of C. Miller Fisher
Chairman: Raymond D. Adams, Boston, MA
Participants :
Clark Millikan, The Differential Diagnosis of
Transient Focal Cerebral Attacks
James F. Toole, Is Subclavian Steal a Syndrome?
Peritz Scheinberg, The Pathophysiology of
Ischemic Edema
Jack P. Whisnant, Mortality from Intracranial
Aneurysms
Jay P. Mohr, The Vascular Basis of Wernicke’s
Aphasia
5:30 Poster Session
-6:3 0
29. a-Adrenergic Control of Brain
Parenchymal Blood Flow
Lewis L. Levy and Jerry D . Wicke, West Haven, CT
30. Temporal Patterns of Cerebral Blood Flow
in Experimental Basal Ganglia Hemorrhage
Allan H. Ropper and Nicholas T . Zewas, Boston,
MA
3 1. Impaired Oxygen Consumption Causes
Tissue Hyperoxygenation in Postischemic
Reperfusion
Kyuya Kogure, Raul Busto, and Peritz Scheinberg,
Miami, FL
32. Induced Hypertension Impairs Recovery of
Electrical Brain Activity during Postischemic
Reperfusion
Kyuya Kogure, Raul Busto, and Peritz Scheinberg,
Miami, FL
33. Tomographic Measurement of Cerebral
Blood Flow with the C1502
Continuous-Inhalation Technique:
Experimental Evidence
J . C. Baron, R. Naquet, M . Steinling, C. Loch, and
F . Soussaline, Orsay and G d France
34. &-Adrenergic-sensitive Adenylate
Cyclase in Cat Pial Vessels
James A . Nathanson, Boston, M A
35. Sleep Apnea: Local Cerebral Blood Flow
Changes during Sleep and Activation
Measured by Xenon CT Scans
John S. Meyer, L. Anne Hayman, S . Nakajima,
T . Amano, Sabri Derman, Parry Lauzon, and
I . Karacan, Houston, T X
36. Cerebral Metabolism during Hypoxia and
during Recovery from Hypoxia: Logic of
Treatment with Cerebral Depressants
Alan A . Artru and John D. Michenfelder, Rochester,
MN
37. A New Approach in the Experimental
Investigation of Stroke
Justin A . Ziuin and Umberto DeGirolami, Worcester,
MA
38. Carotid Ultrasound Real Time in
Cerebrovascular Disease
John A. H. Porter, James C. Barton, and Denis C.
Nathan, Milwaukee, WI
39. Differential Risk Factors for Completed
Stroke and Transient Ischemic Attacks: Study
of Vascular Diseases (Hypertension, Cardiac
Disease, Peripheral Vascular Disease) and
Diabetes Mellitus
Bruce S. Schoenberg, Deuera G. Schoenberg, David A .
Pritchard, Abraham M . Lilienfeld, and Jack P.
Whisnant, Bethesda, MD, Brisbane, Australia,
Baltimore, MD, and Rochester, M N
40. Subdural Hematoma Mimicking Other
Stroke Syndromes
L. Caplan, D. Hier, J . Goodwin, and L. Ferguson,
Chicago, I L
41. “Dizzy Spells” in the Elderly-A
Predictor
of Stroke?
A. Heyman, W. Wilkinson, R. Pfeffer, and T . Vogt,
Durham, N C , Irvine, C A , and Seattle, WA
42. Long-term Effect of Internal Carotid
Artery Occlusion With or Without Superficial
Temporal Artery-Middle Cerebral Artery
Anastomosis
M. C. Lee, S . N.Park, R. B . Lowenson,
A. C . Klassen, and J . A. Resch, Minneapolis, MN
43. Excessive Factor VIII Coagulant Activity
in Transient Ischemic Attacks
Marc Fisher, Peter H. Levine, Albert L. Fullerton,
Celeste P. Duffr, and James J . Hoogasian, Worcester,
MA
44. Posttraumatic Spinal Epidural Hemorrhage
without Bony Injury: Case Report and Review
of the Literature
Dominic Foo and Alain B. Rossier, Boston, M A
45. Current Management of Lobar
Intracerebral Hematomas
Joseph C. Masdeu and Frank A. Rubino, Hines, IL
46. Brain Damage Causing Stuttering
David B. Rosenfield, Susan Miller, and Michael
Feltouich, Houston, T X
47. Pseudo Abducens Palsy with Midbrain
Lesions
J . Masdeu, R. Brannegan, M . Rosenberg, and
G. Dobben, Hines and Chicago, IL
Tuesday, September 9
Morning Session
8.00 Poster Session (continental breakfast served)
-9:OO
48. Hormones in Pituitary Tumors: Common
Occurrence of Thyrotropin, Gonadotropins, or
Both
Humberto M . Cravioto, Earl A. Zimmewnan,
Terutaka Fukaya, David L. Kleinberg, and Eugene S.
Flamm, New York, N Y
49. A Direct Inhibitory Effect of Reserpine on
Pituitary Prolactin Release
Ivan S. Login and Robert M . MacLeod,
Charlottesville, V A
50. Impaired Spatial Ability in Men with
Hypogonadotropic Hypogonadism
Daniel B. Hier and William F . Crwley,Jr.,
Chicago, IL, and Boston, M A
5 1. Hyposexuality: A Complication of
Complex Partial Epilepsy
Paul B. Pritchard, I I I , Charleston, SC
52. Daily Pattern of Somatostatin in the
Cerebrospinal Fluid of the Rhesus Monkey:
Effect of Environmental Lighting
Michael A . Arnold, Mark J . Perlow, Steven M.
Reppert, Otto P . Rorstad, andJoseph B . Martin,
Boston, M A , and Washington, DC
53. Axonal Neuropathy in Acute
Streptozotocin Diabetes
S. Chokroverty, M . G. Reyes, D . Seiden, and
N . Nishimura, Lyons and Piscataway, NJ, and
Chicago and Hdnes, IL
54. Protective Effects of Corticosteroids on
Fatty Acid-induced Cerebral Edema
J . J . Caronna, P. H . Chan. and R. A. Fishman, San
Francisco, C A
55. Bulk Flow of Interstitial Fluid in
Periventricular White Matter with Increased
CSF Pressure in Cats
Gary A. Rosenberg and Walter T . Kyner,
Albuquerque, NM
Program and Abstracts, American Neurological Association 85
56. Galvanic Vestibular Tests in the
Assessment of Coma and Brain Death
Joseph U . Toglia, Rasheed U.Adam, and George
Stewart, Philudelph id,P A
57. Short-Latency Somatosensory Evoked
Responses in Evaluation of Comatose Patients
Elliott M . Marcus, Raymond Girouard, and Bernard
Stone, Worcester, M A
58. Evaluating Prognosis in Nontraumatic Coma
David E. L H Jm~ d Fred Plum, New York, N Y
59. Portacaval Shunting Changes Neuronal
Tolerance to Ammonia
W. Raabe and G . Onsted, Minneapolis, M N
60. VEP Latency Changes Due to
Neurotransmitter Deficiency in Humans
ItJanBodis-Wollner. Melvin D . Yahr. and Leland H .
Mylin, New! York, N Y
61. Metrizamide Competitively Inhibits
Hexokinase
John M. Bertoni, Guillermo M . Alexander, and
Robert Jay Schwartzman, San Antonio, TX
62. Herpes Simplex Virus Thymidine Kinase
Expression in Infection of the Trigeminal
Ganglion
Richard B. Tenser, Hershey, PA
63. The Syndrome of Head Tilt and
Convergence-Retractory Nystagmus:
Localization in a Fragment of the Sylvian
Aqueduct Syndrome
Sanford H . Auerbach, ThesleeJ . DePiero, and Flaviu
Romanul, Boston, M A
64. Nontraumatic Bilateral Fourth Nerve
Palsies: A Dorsal Midbrain Sign
W. H. Cobbs, N.J . Schatz, and P. J . Savino,
P hiladeelphia, PA
65. Neuronal Ceroid Lipofuscinosis Diagnosed
by Semi-thin Sections of Peripheral
Lymphocytes from Patients with Normal
Routine Light Microscopy
Richurd G. Curless,Joseph C. Parker, John T . Flynn,
und Joj) Harrison, Miumi, FL
66. Real-Time B-Mode Ultrasonography
(Sector Scan) of the Infant Brain
L. Matthew Frank, Frederick H . Wirth,Jr., and
Edward H. Karotkin, Norfolk, V A
67. Hemidystonia following “Minor” Head Trauma
Anthony J . Mauro, Stanley Fahn, and Burry
Russman, Seattle, WA, New York, N Y , and
Newington, C T
68. Modulation of Tardive Dyskinesia by
Estrogen: Neurochemical and Behavioral
Studies in Male Rats
K. O’Neil Perry, Bruce 1. Diamond, and John H .
Gordon, Chicago, IL
69. Prolonged but Reversible Parkinsonism
following Injections of Fluphenazine Decanoate
G . F. Wooten, R. H . Sundermann, C.-H. Cheng, and
W . E. Dodson, St. Louis, MO
70. Physiological Observations in Sydenham’s
Chorea
Mark Hallett and Chavles Kaufmun, Boston, M A
86
Annals of Neurology Vol 8 No 1 July 1980
7 1. Electromyography during Ballistic
Movement: Possible Mechanism of the
Two-Burst Pattern
Ronald W . Angel. Palo Alto, C A
7 2 . “Late” Electromyographic Responses to
Ankle Displacement in Hemiplegia and Basal
Ganglion Diseases
Naunihal Singh and Stanley Fuhn, New York, N Y
9:OO Symposium on Pituitary Tumor
-12:OO Chairman: Joseph B. Martin, Boston, MA
Participants:
Seymour Reichlin, Hypothalamic Regulation of
Anterior Pituitary
G. M. Besser, Treatment of Hypersecretory
Tumors by Dopamine Agonists
10:OO Coffee Break
--10:30
Dorothy T. Krieger, Medical Approaches to
Cushing Disease
Edward R. Laws, Jr., Surgical Removal of
Hypersecretory Adenomas by Microsurgery
I 1 3 0 Panel Discussion
--12:oo
12:OO Second Executive Session of Membership
-1:3O
Afternoon Session
12:jO Poster Session
-1:30
73. Solitary Intracranial Plasmacytoma
Howard D . Weiss, Allen Krunzholz, VioletJiji, and
Daniel Bakal, Baltimore, M D
74. Orthostatic Hypotension with Brainstem
Neoplasms
C. Y . Hsu, W . Wingfield,Jr., E. L. Hogan,
J . G. Webb, P. L. Perot, P. J . Privitera,
J . D. Balentine, and 0. R. Talbert, Charleston, SC
75. Diagnostic Features of Intracranial
Malignant Melanoma
Gary Gerard and Richard F. Wagner, Great Neck
and Valhalla, N Y
76. Computed Tomography and Horseradish
Peroxidase Permeability: Correlation in
Experimental Gliomas in Dogs
Dennis R. Groothuis, Joan M . Fischer, Michael A.
Mikhael, and Nicholas A . Vick, Evanston, I L
77. Cerebellopontine Angle Lipoma: A Review
William Deans, Robert Shuman, Solomon Bloch, Lyal
G. Leibrock, and F. Miles Skultety, Omaha, N B
78. Immune Surveillance and Brain Cancer
H . Richard Beresford, J . Gregorji Cairncross, and
Lloyd J . Old. Manhasset and N w York, N Y
79. Computed Tomographic Findings in
Intracranial Gliosis
Leon A. Weisberg, New Orleans, L A
80. Mismatch between Neuropathology
Manpower and Workload: Analysis of 100
Neurology Training Centers, with
Implications for Training and Research
Anthony C . Breuer, William C . Schoene, andJohn P.
Conomy, Cleoeland, OH, and Boston. M A
92. A Low-Molecular-Weight Demyelinating
Factor in Human Serum
Frederick Wougram, Los Angeles, C A
93. Serial Changes in Cognitive Components of
Auditory Evoked Potentials in Dementing
Illness
K. Squires, T. Chippendale, and A. Starr, Imine, C A
81. Use of a Visual Evoked Potential Battery in
the Evaluation of Multiple Sclerosis
Stanley N.Cohen, Karl Syndulko, Edward C .
Hansch, Eugene Gilden, Kenneth Phillips, and
Wallace W . Tourtellotte, Los Angeles, C A
82. Evidence for the Presence of Abnormal
B-Lymphocyte Clones in the Peripheral Blood
of Patients with Multiple Sclerosis
Stephen L. Hauser, Kenneth A. Ault, and Howard L.
Weiner, Boston, M A
94. Instrumental Neutron Activation Analysis
of Brain Aluminum and Other Trace Elements
in Alzheimer Disease and Aging
W. R. MarkeJbery, W. D . Ehmann, T . 1. M . Hosuin,
M . Alauddin, and D . T . Goodin, Lexington, KY
95. Nonfamilial Olivopontocerebellar
Atrophy: Clinical and CT Features
L. Caplan, C . Thomas, D . Patel, I . Sherman, and
T . Kemper, Chicago, IL, and Boston, M A
83. Primary Progressive Multifocal
Leukoencephalopathy of the Cerebelloponti ne
Type Diagnosed Premortem by Cerebellar
Biopsy
H . Royden Jones, E. Tessa Hedley- Whyte,
Joseph E . Kelleher, and Stephen R. Friedberg,
Boston, M A
96. Cerebellar Atrophy: Relationship to Aging
and Cerebral Atrophy.
W. C . Koller, S. L. Glatt,J . H . Fox, A. W . Kaszniak,
R . S. Wilson, and M . S. Huckman, Chicago, IL
97. Epidemiological Patterns and Clinical
Features of Dementia in a Defined U.S.
Population
Emre Kokmrn and Bruce S. Schoenberg, Rochester.
M N , and Bethesda, M D
84. Myelin Proteolipid Protein in Sera and
Cerebrospinal Fluid after Damage to the
Central Nervous System
John L. Trotter, Harish C. Agrawal, Cindy
Wegerschiede,and Larry Lieberman, St. Louis, MO
85. Possible Risk Factors in Multiple Sclerosis
as Found in a National Twin Study
R. D . Currier and R. Eldridge. Jackson, MS, and
Bethesda, M D
2;OO Simultaneous Platform Sessions C and D
-4:30
86. Primacy Central Nervous System
Demyelination in Ross River Virus
3:OO Coffee Break
Encephalitis
Alan R. Seay, J e r v S. Wolinsky, and Richard T .
Johnson, Baltimore, M D
-3 ;.3 0
87. Serum Immunoglobulin Levels in
Guamanian Amyotrophic Lateral Sclerosis and
Parkinson Disease
Paul M. Hoffman, Deanna S. Robbins, Clarence J .
Gibbs, Jr., and D . Carleton Gajdusek, Charleston,
SC, and Bethesda, M D
88. Antibody-dependent Cytotoxicity
Mediated by Normal and MS Mononuclear
Cells against Isolated Cultured Glial and
Neuronal Targets
Roger M . Morrell, Detroit, MI
89. Fucosidosis Presenting as a
Leukodystrophy
Edwin H . Kolodny, Ana Sotrel, William Cable,
Atilano Lacson, Michael J . Bresnan, Peter Daniel,
Roger Williams, James Evans, and Allen C. Crocker,
Waltham and Boston, M A
90. Plasmapheresis in Multiple Sclerosis:
Correlation of Clinical Improvement with
Increased Suppressor Cell Activity in
Peripheral Blood
Bhupendra 0. Khatri, Michael P. McQuillen, Susan
M. Koethe, Clara Hussey, and A n n Cook, Milwaukee,
Wl
91. Cerebrospinal Fluid Mononuclear
Phagocytes and IgG-binding Mononuclear
Cells in Multiple Sclerosis: Effect of Steroid
Treatment
B. R. Brooks, P . K. Coyle, R. L. Hirsch, S. Cohen,
and R . T .Johnson, Baltimore, M D
C. Chairman: David Pleasure, Philadelphia, PA
Secretary: Walter G. Bradley, Boston, MA
98c. Delayed Metrizamide CT Observations in
Syringomyelia
H . J . M . Barnett, A. Fox, F . Vinuela, and
S. J . Peerless, London. Ont, Canada
99c. Relief of Chronic, Intractable Sciatica by
Dorsal Root Ganglionectomy
Arthur Taub, New Haven, C T
1OOc. Studies in Familial Multiple Sclerosis
G. C. Ebers and D. W. Paty, London, Ont, Canada
101c. Treatment of Multiple Sclerosis with a
Synthetic Polypeptide: Preliminary Results
M . B. Bornstein, A . , I . Miller, D . Teitelbauni,
R. Arnon, and M . Sela, Bronx, N Y . and Rehovot,
Israel
102c. Association of Autoimmune Diseases and
Cellular Immune Response to the
Neuritogenic Protein in Guillain-Bar&
Syndrome
Oded Abramsky, Isabelle Korn-Lubrtzky, and Dvora
Teitelbaum,Jerusalem and Rehouot, Israel
103c. Experimental Pontine and Extrapontine
Myelinol ysis
Robert Laureno, Washington, DC
104c. Promotion of Microtubule Assembly
by Isaxonine in Avian and Human
Dystrophic Cells
Jerry W. Shay, Howard Feit, and Leigh E. Thomas,
Dallas, T X
Program and Abstracts, American Neurological Association 87
105c. Iris Pigmentation (Melanin) in
Segmental Dystonic Syndromes Including
Torticollis
Julius Korein, New York, N Y
D. Chairman: Robert J. Joynt, Rochester, NY
Secretary: Alexander G. Reeves, Hanover, N H
98d. The Tegmental Mechanism for Conjugate
Eye Movement
Derek Denny-Brown, Boston, M A
99d. Diagnosis of Sleep Apnea by Daytime
Polysomnogram
G. Browne Goode and Howard Slyter, San Francisco,
CA
100d. Sleep Duration, Sleep Stages, and
Waking Time Are Related to Circadian Phase
in Young and Older Men during
Nonentrained Conditions
Elliot D . Weitzman, Charles A. Czeisler, Janet C.
Zimmerman, Martin C. Moore-Ede, and Joseph M .
Ronda, New York, N Y , and Boston, M A
]Old. Sleep Apnea and Hypoventilation
Syndrome Associated with Acquired
Nonprogressive Dysautonomia
Yitzchak Frank, Richard E. Kravath, Kiyoharu
Inoye, Asao Harano, Charles P. Pollak, and Elliot D .
Weitzman. Bronx? N Y
102d. An Electrophysiological Study of
Complex Spinal Reflexes in Brain Death
Douglas B. Gersh, Leopold J . Streletz, Richard A.
Chambers, and Richard G. Berry, Philadelphia, P A
103d. Apneic Facial Immersion-A Test of
Vagal Function
Raniesh K. Kburana, Baltimore, M D
104d. Perivascular Connections from the
Trigeminal Ganglia of the Cat: A Possible
Neuroanatomical Substrate for Vascular
Headaches in Humans
Marc Mayherg, Robert Langer, and Michael A.
Moskowitz, Cambridge, M A
105d. Hydrocephalus-A Hemodynamic and
Hydrodynamic Disorder
D . N . White, Kingston,, Ont, Canada
4:30 Poster Session
-5 :30
106. Dominantly Inherited Ataxia with Motor
Neuron Disease and Abnormal Urinary
Glycolipid
Richard Berenberg, George Howard, and Donald H .
Harter, Chicago, IL
107. Amino Acid Content of Spinal Tissue
from Patients Dying of Motor Neuron Disease
Bernard M. Patten, Harold M . Kurlander, and
Bradley Euans, Houston, T X
108. Circulating Protease Inhibitors in
Amyotrophic Lateral Sclerosis: Reduced
az-Macroglobulin
Barry W . Festofl. Kansas City, KS
109. Increased Sensitivity to Neuromuscular
Blockade in Amyotrophic Lateral Sclerosis
Ajit Chikarnzane and Barry W . FeJtofl, Kansas City,
KS
88 Annals of Neurology
Vol 8 No 1 July 1980
110. Familial Myasthenia with Marked Type I1
Fiber Atrophy and Negative Antibody Studies
Ajit Chikamane, John Kepes, Philip A. Singer, and
Barry W . Festofi, Kansas City, KS
111. Eaton-Lambert Myasthenic Syndrome:
Long-term Treatment of Three Patients with
Prednisone
Ericb W . Streib and David A. Rothner, Omaha, N B ,
and Cleveland, OH
112. Pharyngoesophageal Motor Function in
Patients with Myotonic Dystrophy
H. M. Swick, S. L. Werlin, W . J . Dohbs, and
W.J . Hogan, Milwaukee, WI
113. Muscle Mitochondrial Abnormalities in
the Marinesco-Sjogren Syndrome
Harold G . Marks, Frances Kelleher, Guillermo A .
DeLeon, and J . Richard Bowen, Wilmington, DE,
and Philadelphia, P A
114. Tibial Muscular Atrophy: Familial
Syndromes of Posterior Tibial Weakness
Linton C . Hopkins and Charles M . Epstean, Atlanta,
GA
115. Uniform Type I Fiber Myopathy:
Another Form of Nonprogressive Congenital
Myopathy ?
Shin Joong Oh, Birmingham, A L
116. Fibroblast Stimulating Factor (or Factors)
in Neuromuscular Disease
Judith B. Ulreich, Lawrence Z. Stern, and Milos
Chvapil, Tucson, A 2
117. Variability of Clinical and Pathological
Manifestations in Familial Fiber Type
Disproportion
Roger W . Kula, JGanna H . Sher, S. A. Shafiq, and
Judith Hardy-Stashin, Brookhn, N Y
118. Dominantly Inherited Muscular
Dystrophy with “Ragged-Red’’ Fibers and
Abnormal Mitochondria
Clarence Washington, Arthur Ginsberg, and
S. M . Sumi, Baltimore, M D , and Seattle, W A
119. Membrane Fluorescence Studies of
Dystonic Fibroblasts
Jay W . Pettegrew, Nancy J . Minshew, and John S.
Nichols, Dallas, T X
120. Skeletal Muscle Adaptation to Alcohol
R. G. Haller, N . W . Carter, E. Ferguson, and
J . P. Knochel, Dallas, T X
121. The Effect of Electrical Stimulation on
Denervated Skeletal Myofibers
Bruce R. Pachter, Arthur Eberstein, and Joseph
Goodgold, New York, N Y
122. Introducing a New, Computer-assisted
Technique for Measuring Muscle Fiber
Conduction Velocities at Full Interference
Pattern
Israel Y a m , Mamin B. Shapiro, Andrew Mitz, and
Erik W . Pottala, Bethesda, M D
123. Postpoliomyelitis Amyotrophy with Rod
(Nemaline) Bodies in Skeirtal Muscle
R. A . Brumback, A. F . Borge, and R. W . Leech,
Fargo, N D
124. Xenograft Studies in Primary Amyloid
Neuropathy
Mario Kornfeld, Otto Appenzeller, and Ruth
Atkinson, Albuquerque, N M
125. The Pathogenesis of Pneumatic
Tourniquet Paralysis in Humans
William F. Brown and Stephen K . Yates, London,
Ont, Canada
126. Familial Subacute
Polyradiculoneuropathy of Infancy
S. M . Sumi, Cheng-Mei Shaw, and Coldevin B.
Carlson, Seattle, W A
127. Value of Needle Examination versus
Sensory Latencies in Carpal Tunnel Syndrome
Lisa P. Trofatter and E. Wayne Massey, Durham,
NC
128. In Vivo Documentation of Dysfunction in
Alpha Motor Axons of Different Diameter
James Domingue, B. T . Shahani, and R. R. Young,
Boston, M A
129. Frequency and Type of Nerve Injury
Associated with Coronary Artery Bypass Graft
Surgery
Richard J . Lederman, Anthony C . Breuer, Anthony J .
Furlan, Maurice R. Hanson, Floyd D . Loop, Delos M .
Cosgrove, and F . George Estafanous, Cleveland, OH
6 30 Cocktails and Dinner
136. Increased Blood-Brain Barrier
Permeability and the Effect of Catecholamines
on Cerebral Oxygen Utilization
Alan A. Artru and John D. Michenfelder, Rochester,
MN
137. “Crossed Cerebellar Diaschisis” in Human
Supratentorial Brain Infarction
J . C. Baron, M. G. Bousser, D . Comar, and
P . Castaigne, Orsay and Paris, France
138. Peripheral Sympathetic Nerves Replace a
Central Cholinetgic Pathway after Injury
James N . Davis and Kezth A . Crutcher, Durham, N C
139. Choline Chloride in Huntington Disease
Kenneth L . Davis, Leo E . Hollzster, Stephen M . Stahl,
and Philip A. Berger, New York, N Y , and Stanhrd,
CA
140. Enkephalins and Experimental
Extrapyramidal Movement Disorders
B . I. Diamond and R. L . Borison, Chicago, I L
141. New Therapeutic Forms of L-Dopa
B . I. Diamond, K. S. Rajun, and R. L. Borison,
Chzcago, I L
142. Amantadine and Gilles de la Tourette
Syndrome
R . L. Borison andJ. M . Davis, Chicago, I L
143. Muscle Pyruvate Oxidation in
Spinocerebellar Degenerations
Owen B. Evans, Nashville, T N
Wednesday, September 10
8:OO Poster Session (continental breakfast served)
-9.00
130. Digoxin-induced Cardiac Arrhythmia:
Digitalization of Receptor Sites in Brainstem
A. Bhagat, J . D . Mann, T . W . Furlow, Jr.,
H . Traurig, and N . H . Bass, Lexington, K Y , and
Charlottesville, V A
131. Barbiturates and Transmitter Release at
the Neuromuscular Synapse
Jonathan H. Pincus and Nancy F . Insler, New
Haven, C T
132. Valproic Acid Interaction with
Carbamazepine
G. Mattson, R. H . Mattson, a n d J . A. Cramer,
West Haven, C T
133. Quantitative Measurement of Local
Metabolic Rate for Glucose Utilizing Tritiated
2-Deoxyglucose
Guillevmo M . Alexander, Robert Jay Schwartzman,
Rodney D . Bell, Jen YE, and A n n Renthal, San
Antonio, T X
134. Effect of Norepinephrine Depletion on
Potassium Transport in Cerebral Cortex
Thomas J . Sick, Sami 1. Harik, Joseph C . LaManna,
and Myron Rosenthal, Miamt, FL
135. Dichloroacetate Stimulates Pyruvate
Dehydrogenase Synthesis and Activity in Rat
Liver
Owen B. Evans and Peter W . Stacpoole, Nashville,
TN
144. Glutamate Dehydrogenase Deficiency in
Spinocerebellar Degenerations: Correlation
with Adult-onset Recessive Ataxia
Andreas Plaitakas, Sol1 Bed, William 0 . NicklaJ, and
Melvin D . Yahr. New York, N Y
145. Portuguese Autosomal Dominant
Hereditary Ataxia of Unknown Cause
(“PADHAUC”)
Harmeet Sachdev, Lysia Forno, and Chades A. Kune,
Palo Alto and Hayward, C A
146. Derangement of Voluntary Movement in
Athetosis
Mark Hallett and Norbert0 Alvarez, Boston, M A
147. Isoniazid in Huntington Disease: Effect
on Chorea and GABA Levels
AT. V. Bala Manyarn, Leonard Katz, Theodore A.
Hare, Kathryn KanaefJki, and Robert D . Tremblay,
Wilmington, DE, and Philadelphia, P A
148. Treatment of Face Pain with Baclofen
Gerhard H. Fromm, Chrrstopher F. Terrence, and
Amrik S. Chattha, Pittsburgh, P A
149. Purine Nucleotide Metabolism in
Myoadenylate Deaminase Deficiency
Tetsuo Ashizawa, Bernard M . Patten, and Rzchard
L. Sabina, Hoaston, T X , und Durham, N C
150. Altered Muscle Polyamine Levels in
Human Neuromuscular Diseases
Anna M . Kaminska, Lawrence Z . Stern, Joanne S.
Finch, and Diane H . Russell, Tucson, AZ
Program and Abstracts, American Neurological Association 89
151. Chondrodystrophic Dwarfism w i t h
Continuous Muscle Fiber Activity
(Schwartz-Jampel Syndrome): Description of
Additional Abnormalities
K. Engebretson, W. H . Olson, G. G. Gascon, and
R. A. Brumback, Fargo, N D
152. Trismus: A New Sign in Polymyositis
Ajit Chikarmane, Philip A. Singer, and Barry W.
Festoff; Kansas City, KS
153. Illusions of Supernumerary Limbs i n
Myelopathy
Judith Capraro, Lawrence Jacobs, William McHugh,
and Svend Gdthgen, Bufialo, N Y
154. Characterization of Altered Neuronal
Proteins i n Alzheimer Disease
D . J . Selkoe, F. J . Salazur, B. A. Brown, and
C. A. Marotta, Belmont, MA
9.00 The Foster Ettling Bennett Memorial Lecture
-1 0:OO Receptors i n the Brain
Solomon H . Snyder, Bahimore, M D
1O:OO Coffee Break
-10~30
10:30 Symposium on Neuropeptides
-12:30 Chairman: Earl A, Zimmerman, New York, N Y
Participants :
Earl A. Zimmerman, Peptide Pathways in the
Central Nervous System
Robert L. MacDonald, Peptides as
Neurotransmitters
Wylie Vale, Peptide Analogs: Future Therapeutic
Implications
Alan I. Faden, The Role of Endorphins in Shock
and Spinal Cord Injury: Clinical Implications
Abstracts
la. Positron Imaging of the Normal
Brain-Functional Asymmetries
S. Finklestein, N. A. Alpert, R. H . Ackerman,
F . S. Buonanno, J . A. Correid,J. Chang, S. Kulas,
and G. L. Brownell, Boston, MA
Positron images in 14 awake normal right-handed subjects
indicate functional asymmetries in cerebral blood flow
(CBF) and metabolism. Transverse section imaging permits
investigation of physiology in deep as well as superficial
structures. Studies of CBF (14 subjects) and oxygen metabolism (11 subjects) were obtained in resting volunteers
during continuous inhalation of Cl5O, and l5OZ, respectively. Two of these subjects also had studies of glucose metabolism following intravenous injection of "FDG.
Qualitative images were examined in all subjects. In 3,
quantitative values for flow and metabolism were obtained.
Cerebral blood flow and metabolism were coupled in all
brain regions. Oxygen metabolism was coupled to glucose
metabolism in subjects in whom this was studied. In all
subjects, flow and metabolism were greater in the occipital
than in the parietooccipital cortical regions and in the inferomedial frontal than in the lateral frontal cortical regions. In 8 of the 14 subjects there was evidence of greater
flow and metabolism in the dominant frontotemporal region compared to the corresponding nondominant region.
In no subject was the converse true. Positron images in
90 Annals of Neurology Vol 8 No 1 July 1980
subjects with diseased brains must be interpreted in light of
asymmetries found in normal resting individuals.
2a. Selective Necrosis i n t h e Central Nervous
System-Histopathological Observations in the
Macaque Monkey following Transient Focal
Cerebral Ischemia
U.DeGirokdmi, R. M. Crowell, and F . W . Marcoux,
Worcester,Boston, and Burlington, M A
Forty unanesthetized macaque monkeys underwent reversible middle cerebral artery occlusion via a previously
implanted transorbital snare ligature. Focal cerebral ischemia, followed by reperfusion, was instituted for periods of
15 minutes to four hours. Animals were sacrificed by intracardiac formalin perfusion two weeks later. Brains were
embedded in celloidin and serially cut horizontally, and
sections at 3.75 mm intervals were sained with hematoxylin and eosin, cresyl violet, and Loyez.
The following generalizations summarize our results: (1)
in comparison with our previous studies using the same
protocol and longer periods of occlusion, reduction of the
duration of occlusion below four hours results in a decrease
in the size and change in the distribution of the lesion:
shorter occlusion times involve deep structures and spare
the cortex; (2) gray and white matter have different susceptibilities to ischemia: as the duration of occlusion is decreased, the white matter is less vulnerable to infarction
than the gray; and (3) within the gray matter, gradients to
ischemic injury exist: neurons (small) and pericapillary tissues seem most sensitive. This study presents histological
evidence of selective necrosis presumed to be due to selective
vulnerability in experimentally induced ischemia. (Supported by Grant NS10828 from NINCDS.)
3a. Local Metabolic Responses in Brain
Accompanying Motor Activity
C. Kennedy, M . Miyaoka, S. Suda, K. Macko, C.Jawis,
M . Mishkin, and L. Sokolofi, Bethesda, M D
Alterations in neuronal activity have been shown to be accompanied by corresponding changes in rates of glucose
utilization. We employed the ['4Cldeoxyglucose method to
determine the magnitude of such changes in the niotor,
somatosensory, and cerebellar pathways of rhesus monkeys
during the performance of a task that required reaching
toward and pressing plastic keys. Unilateral arm and hand
movements were executed approximately forty times per
minute throughout a 45-minute experimental period. Rates
of glucose utilization were measured at all levels of the
neuraxis in four working and four inactive monkeys.
No consistent right-left differences were found in any
structure in the inactive animals. In working animals, unilateral increments varying up to 50% were found in the
following structures: laminae I through IX of the cervical
cord, the cuneate nucleus, the lateral reticular nucleus, crus
I1 of the cerebellum, the red nucleus, the ventral posterolateral nucleus of the thalamus, part of the globus pallidus,
and discrete portions of the posterior parietal, somatosensory, primary, premotor, and supplementary motor cortices. The study revealed that more energy is expended in
somatosensory monitoring and cerebellar control systems
than in the primary motor system itself during repetitive
arm and hand movements.
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