105th Annual Meeting of the American Neurological Association September 7-10, 1980 Sheraton Boston Hotel, Boston, MA 5a. Experimental Hyperglycemia and Diabetes Mellitus Worsen Stroke Outcome W . Pulsinelli, B. Sigsbee, S. Waldman, D. Rawlinson, P. Scherer, and F . Plum, New Yovk, N Y 6a. Ischemic Brain Edema Requires Tissue Necrosis C . K. Petito, W. A. Pubinelk, G.Jacobson, and F . P b m , New York, N Y 7a. T h e Role of Hydrocephalus in Unexplained Late-Life Gait Disorders C . M . Fisher, Boston, M A Program Sunday, September 7 Joint Session with the American EEG Society 1:30 Presidential Symposium: T h e Topography of -4:30 Cerebral Function Chairman: Richard N. Harner, Philadelphia, PA Participants: Martin Reivich, Cerebral Metabolism as an Index of Local Brain Function Norman Geschwind, Cortical Localization of Altered Behavior David Ingvar, Delineation of Functional Cortical Areas by Regional Blood Flow Richard N . Harner, Computerized EEG Topography of Focal Cerebral Lesions 6:OO Cocktail party -8:oo Museum of Fine Arts, Boston B. Chairman: James A. Ferrendelli, St. Louis, MO Secretary: Marvin Fishman, Houston, TX Ib. Delayed High-Iodine-Dose Contrast Computed Tomography for Cranial Neoplasms L. Anne Hayman, Robert A. Evans, and Vincent C. Hinck, Houston, T X 2b. histological Characteristics and Biological Behavior of Oligodendrogliomas M. T. Smith, C . L. Ludwig, V . W. Armbmstmacher, J . M . Henry, and K . M . Earle, Bethesda, M D , and Washington, DC 3b. Melanotropic Effects of Benzodiazepines: Correlation with a High-Affinity Receptor E. Matthew, D . L. Engelhardt, J . D . L s k i n , and E . A. Zimmerman, New York, N Y Monday, September 8 Morning Session 9:OO Presidential Address Peritz Scheinberg, Miami, FL 9:30 Simultaneous Platform Sessions A and B -12:oo 4b. Prolonged lntracerebral Infection with Poliovirus in Asymptomatic Mice James R. Miller; New York, N Y 5b. Focal Cortical Seizures Inhibit Brain Protein Synthesis Robert C. Collins, Carolyn B . Smith, and Louis Sokolofl, St. Louis, MO, and Bethesda, M D 6b. Clinical Aspects of Status Epilepticus in an Unselected Urban Population Roger P. Simon and Michael J . Aminoff, San Francisco, CA 7b. Removal of Sedative Antiepileptic Drugs from t h e Regimens of Patients with Intractable Epilepsy William H. Theodore and Roger J . Porter, Bethesda, MD 10:30 Coffee Break -1 I :oo A. Chairman: Joseph M. Foley, Cleveland, OH Secretary: John N. Whitaker, Memphis, TN la. Positron Imaging of the Normal Brain-Functional Asymmetries S. Finklestein, N.A . Alpert, R. I € . Acketman, F . S. Buonanno, J . A. Correia, J . Chang, S. Kulas, and G. L. Brownell, Boston, M A 2a. Selective Necrosis i n the Central Nervous System-Histopathological Observations in the Macaque Monkey following Transient Focal Cerebral Ischemia U . DeGirolami, R . M . Crowell, and F. W . Marcoux, Worcester, Boston, and Burlington, M A 3a. Local Metabolic Responses in Brain Accompanying Motor Activity C. Kennedy, M . Miyaoka, S. Suda, K. Macko, C . Jarvis, M. Mishkin, and L. Sokolofi, Betbesda, MD 4a. Recovery from Locked-In Syndrome Elizabeth A . McCusker, Richard A. Rudick, and Robert C . Griggs, Rochester, N Y 12:OO First Executive Session of Membership -I :30 1 2 3 0 Poster Session -1 :30 8. Electrical Kindling of the Amygdala: Evidence Against a Muscarinic Mechanism C. G. Wasterlain, V .Jonec, Harris Hubeman, and Anne M . Morin, Sepulzvda, C A 83 9. Loss of Autoregulation of Cerebral Blood 23. Postictal Pleocytosis James W . Schmidley and Roger P. Simon, San Francisco, C A 24. Effect of Chronic Seizures on Religiosity L. James Willmore, Kenneth M . Heilman, Eileen Fennell, and Ruth M . Pinnas, Gainesville and Miami, FL 25. Hysterical “Seizures”-The Use of Saline Infusion and Suggestion as a Provocative Test in 41 Cases Robert J . Cohen and Cavy Suter, Richmond, VA 26. Cataplexy in Variant Forms of Niemann-Pick Disease Raymond S. Kandt, Ronald Emerson, and Hugo Moser, Baltimore, M D 27. Electrophysiological Assessment of Facial H ypesthesia J u n Kimura and Thoru Yamada, Iowa City, IA 28. Major Neurological Learning Experiences Augmented by Matrix Organization: A Rapid Method of Assessing Qualitative and Quantitative Aspects of a Training Program Anthony C. Breuer, Lisa R. Rogers, andJohn P. Conomy, Cleveland, OH Flow: An Asset during Single Seizures, a Liability during Status Epilepticus Claude G. Wasterlain and Stephen L. Graham, Sepulveda, C A 10. Electrophysiological Effects of Cyclic Nucleotides in Brain Tissue in Vitro J . A. Ferrendelli, A. C. Blank, D. A . Kinrcher- and E. W . Lothman, St. Louis, MO 11. Electroshock Seizures: Effect on Brain Adenosine and Its Metabolites Edward Lewin and Virginia Bleck, Denver, CO 12. Neurotoxicity of a New Chemotherapeutic Agent, Phosphonoacetyl- 1-Aspartate: Clinical Observations and a Laboratory Model R. G. Wiley and R. J . Gralla, New York, N Y 13. Myokymia of Segmental Spinal Cord Origin Godofredo R. Celis, Roger W . Kula, Mahendra Somasundaram, Joanna H . Sher, and Henry S. Schutta, Brooklyn, N Y 14. Phenytoin and the “Safety Margin” of Neuromuscular Transmission L. Fernando Franco and Barry W . Festofi, Kansas City, KS 15. Long-Latency Event-related Potentials in Normal Aging and Dementia Karl Syndulko, Edward C. Hansch, Stanley N . Cohen, James W . Pearce, Barbara Montan, Zw Goldberg, Wallace W . Tourtellotte, and Alfred R. Potvin, Los Angeles, CA, and Arlington, T X 16. Focal Epileptogenesis and the Visual Evoked Response Arthur D . Rosen and Anne H . Remmes, Stony Brook, NY 17. A Novel Approach in Detecting Toxic Axonal Neuropathies: The Brainstem Somatosensory Evoked Potential Joseph Arezzo, Herbert Schaumburg, Peter Spencer, and Herbert G. Vaughan,Jr., Bronx, N Y 18. Binaural Interaction in Human Brainstem Potentials Robert A. Levine, Boston, M A 19. A Comparison of Electrical Studies of Brain Function in Epileptic Patients: Simultaneous EEG and Positron Emission Computed Tomography Jerome Engel, J r , , David E. Kuhl, and Michael E. Phelps, Los Angeles, C A 20. Neurogenic Pulmonary Edema in Unexpected, Unexplained Death in Epileptic Patients Christopher F. Terrence, G u t t i Rao, and Joshua Perper, Pittsburgh, PA 2 1. Mechanisms of Neurogenic Pulmonary Edema following Seizures in Sheep R. P. Simon, L. L. Bayne, and R. F . Tranbaugh, San Franci.uo, C A 22. Electroencephalographic Findings during Cardiac Catheterization Varun K. Saxena, Michael P. McQuillen, Gregory J . Hawington, and Michael H . Keelen, Milwaukee, WI 84 Annals of Neurology Vol 8 No 1 July 1980 Afternoon Session 2:oo Symposium: Surgical Treatment for Epilepsy -3 :30 Chairman: Robert G. Feldman, Boston, MA Participants: Robert Gumnit, Office Evaluation of Candidates for Temporal Lobectomy Jerome Engel, Inpatient Evaluation of Candidates for Temporal Lobectomy Paul H. Crandall, Temporal Lobectomy: Technique and Results Sidney Goldring, Temporal Lobectomy: Technique and Results 3:30 Coffee Break 4:oo 4.90 Symposium on Cerebrovascular Disease, in -5 :3 0 Honor of C. Miller Fisher Chairman: Raymond D. Adams, Boston, MA Participants : Clark Millikan, The Differential Diagnosis of Transient Focal Cerebral Attacks James F. Toole, Is Subclavian Steal a Syndrome? Peritz Scheinberg, The Pathophysiology of Ischemic Edema Jack P. Whisnant, Mortality from Intracranial Aneurysms Jay P. Mohr, The Vascular Basis of Wernicke’s Aphasia 5:30 Poster Session -6:3 0 29. a-Adrenergic Control of Brain Parenchymal Blood Flow Lewis L. Levy and Jerry D . Wicke, West Haven, CT 30. Temporal Patterns of Cerebral Blood Flow in Experimental Basal Ganglia Hemorrhage Allan H. Ropper and Nicholas T . Zewas, Boston, MA 3 1. Impaired Oxygen Consumption Causes Tissue Hyperoxygenation in Postischemic Reperfusion Kyuya Kogure, Raul Busto, and Peritz Scheinberg, Miami, FL 32. Induced Hypertension Impairs Recovery of Electrical Brain Activity during Postischemic Reperfusion Kyuya Kogure, Raul Busto, and Peritz Scheinberg, Miami, FL 33. Tomographic Measurement of Cerebral Blood Flow with the C1502 Continuous-Inhalation Technique: Experimental Evidence J . C. Baron, R. Naquet, M . Steinling, C. Loch, and F . Soussaline, Orsay and G d France 34. &-Adrenergic-sensitive Adenylate Cyclase in Cat Pial Vessels James A . Nathanson, Boston, M A 35. Sleep Apnea: Local Cerebral Blood Flow Changes during Sleep and Activation Measured by Xenon CT Scans John S. Meyer, L. Anne Hayman, S . Nakajima, T . Amano, Sabri Derman, Parry Lauzon, and I . Karacan, Houston, T X 36. Cerebral Metabolism during Hypoxia and during Recovery from Hypoxia: Logic of Treatment with Cerebral Depressants Alan A . Artru and John D. Michenfelder, Rochester, MN 37. A New Approach in the Experimental Investigation of Stroke Justin A . Ziuin and Umberto DeGirolami, Worcester, MA 38. Carotid Ultrasound Real Time in Cerebrovascular Disease John A. H. Porter, James C. Barton, and Denis C. Nathan, Milwaukee, WI 39. Differential Risk Factors for Completed Stroke and Transient Ischemic Attacks: Study of Vascular Diseases (Hypertension, Cardiac Disease, Peripheral Vascular Disease) and Diabetes Mellitus Bruce S. Schoenberg, Deuera G. Schoenberg, David A . Pritchard, Abraham M . Lilienfeld, and Jack P. Whisnant, Bethesda, MD, Brisbane, Australia, Baltimore, MD, and Rochester, M N 40. Subdural Hematoma Mimicking Other Stroke Syndromes L. Caplan, D. Hier, J . Goodwin, and L. Ferguson, Chicago, I L 41. “Dizzy Spells” in the Elderly-A Predictor of Stroke? A. Heyman, W. Wilkinson, R. Pfeffer, and T . Vogt, Durham, N C , Irvine, C A , and Seattle, WA 42. Long-term Effect of Internal Carotid Artery Occlusion With or Without Superficial Temporal Artery-Middle Cerebral Artery Anastomosis M. C. Lee, S . N.Park, R. B . Lowenson, A. C . Klassen, and J . A. Resch, Minneapolis, MN 43. Excessive Factor VIII Coagulant Activity in Transient Ischemic Attacks Marc Fisher, Peter H. Levine, Albert L. Fullerton, Celeste P. Duffr, and James J . Hoogasian, Worcester, MA 44. Posttraumatic Spinal Epidural Hemorrhage without Bony Injury: Case Report and Review of the Literature Dominic Foo and Alain B. Rossier, Boston, M A 45. Current Management of Lobar Intracerebral Hematomas Joseph C. Masdeu and Frank A. Rubino, Hines, IL 46. Brain Damage Causing Stuttering David B. Rosenfield, Susan Miller, and Michael Feltouich, Houston, T X 47. Pseudo Abducens Palsy with Midbrain Lesions J . Masdeu, R. Brannegan, M . Rosenberg, and G. Dobben, Hines and Chicago, IL Tuesday, September 9 Morning Session 8.00 Poster Session (continental breakfast served) -9:OO 48. Hormones in Pituitary Tumors: Common Occurrence of Thyrotropin, Gonadotropins, or Both Humberto M . Cravioto, Earl A. Zimmewnan, Terutaka Fukaya, David L. Kleinberg, and Eugene S. Flamm, New York, N Y 49. A Direct Inhibitory Effect of Reserpine on Pituitary Prolactin Release Ivan S. Login and Robert M . MacLeod, Charlottesville, V A 50. Impaired Spatial Ability in Men with Hypogonadotropic Hypogonadism Daniel B. Hier and William F . Crwley,Jr., Chicago, IL, and Boston, M A 5 1. Hyposexuality: A Complication of Complex Partial Epilepsy Paul B. Pritchard, I I I , Charleston, SC 52. Daily Pattern of Somatostatin in the Cerebrospinal Fluid of the Rhesus Monkey: Effect of Environmental Lighting Michael A . Arnold, Mark J . Perlow, Steven M. Reppert, Otto P . Rorstad, andJoseph B . Martin, Boston, M A , and Washington, DC 53. Axonal Neuropathy in Acute Streptozotocin Diabetes S. Chokroverty, M . G. Reyes, D . Seiden, and N . Nishimura, Lyons and Piscataway, NJ, and Chicago and Hdnes, IL 54. Protective Effects of Corticosteroids on Fatty Acid-induced Cerebral Edema J . J . Caronna, P. H . Chan. and R. A. Fishman, San Francisco, C A 55. Bulk Flow of Interstitial Fluid in Periventricular White Matter with Increased CSF Pressure in Cats Gary A. Rosenberg and Walter T . Kyner, Albuquerque, NM Program and Abstracts, American Neurological Association 85 56. Galvanic Vestibular Tests in the Assessment of Coma and Brain Death Joseph U . Toglia, Rasheed U.Adam, and George Stewart, Philudelph id,P A 57. Short-Latency Somatosensory Evoked Responses in Evaluation of Comatose Patients Elliott M . Marcus, Raymond Girouard, and Bernard Stone, Worcester, M A 58. Evaluating Prognosis in Nontraumatic Coma David E. L H Jm~ d Fred Plum, New York, N Y 59. Portacaval Shunting Changes Neuronal Tolerance to Ammonia W. Raabe and G . Onsted, Minneapolis, M N 60. VEP Latency Changes Due to Neurotransmitter Deficiency in Humans ItJanBodis-Wollner. Melvin D . Yahr. and Leland H . Mylin, New! York, N Y 61. Metrizamide Competitively Inhibits Hexokinase John M. Bertoni, Guillermo M . Alexander, and Robert Jay Schwartzman, San Antonio, TX 62. Herpes Simplex Virus Thymidine Kinase Expression in Infection of the Trigeminal Ganglion Richard B. Tenser, Hershey, PA 63. The Syndrome of Head Tilt and Convergence-Retractory Nystagmus: Localization in a Fragment of the Sylvian Aqueduct Syndrome Sanford H . Auerbach, ThesleeJ . DePiero, and Flaviu Romanul, Boston, M A 64. Nontraumatic Bilateral Fourth Nerve Palsies: A Dorsal Midbrain Sign W. H. Cobbs, N.J . Schatz, and P. J . Savino, P hiladeelphia, PA 65. Neuronal Ceroid Lipofuscinosis Diagnosed by Semi-thin Sections of Peripheral Lymphocytes from Patients with Normal Routine Light Microscopy Richurd G. Curless,Joseph C. Parker, John T . Flynn, und Joj) Harrison, Miumi, FL 66. Real-Time B-Mode Ultrasonography (Sector Scan) of the Infant Brain L. Matthew Frank, Frederick H . Wirth,Jr., and Edward H. Karotkin, Norfolk, V A 67. Hemidystonia following “Minor” Head Trauma Anthony J . Mauro, Stanley Fahn, and Burry Russman, Seattle, WA, New York, N Y , and Newington, C T 68. Modulation of Tardive Dyskinesia by Estrogen: Neurochemical and Behavioral Studies in Male Rats K. O’Neil Perry, Bruce 1. Diamond, and John H . Gordon, Chicago, IL 69. Prolonged but Reversible Parkinsonism following Injections of Fluphenazine Decanoate G . F. Wooten, R. H . Sundermann, C.-H. Cheng, and W . E. Dodson, St. Louis, MO 70. Physiological Observations in Sydenham’s Chorea Mark Hallett and Chavles Kaufmun, Boston, M A 86 Annals of Neurology Vol 8 No 1 July 1980 7 1. Electromyography during Ballistic Movement: Possible Mechanism of the Two-Burst Pattern Ronald W . Angel. Palo Alto, C A 7 2 . “Late” Electromyographic Responses to Ankle Displacement in Hemiplegia and Basal Ganglion Diseases Naunihal Singh and Stanley Fuhn, New York, N Y 9:OO Symposium on Pituitary Tumor -12:OO Chairman: Joseph B. Martin, Boston, MA Participants: Seymour Reichlin, Hypothalamic Regulation of Anterior Pituitary G. M. Besser, Treatment of Hypersecretory Tumors by Dopamine Agonists 10:OO Coffee Break --10:30 Dorothy T. Krieger, Medical Approaches to Cushing Disease Edward R. Laws, Jr., Surgical Removal of Hypersecretory Adenomas by Microsurgery I 1 3 0 Panel Discussion --12:oo 12:OO Second Executive Session of Membership -1:3O Afternoon Session 12:jO Poster Session -1:30 73. Solitary Intracranial Plasmacytoma Howard D . Weiss, Allen Krunzholz, VioletJiji, and Daniel Bakal, Baltimore, M D 74. Orthostatic Hypotension with Brainstem Neoplasms C. Y . Hsu, W . Wingfield,Jr., E. L. Hogan, J . G. Webb, P. L. Perot, P. J . Privitera, J . D. Balentine, and 0. R. Talbert, Charleston, SC 75. Diagnostic Features of Intracranial Malignant Melanoma Gary Gerard and Richard F. Wagner, Great Neck and Valhalla, N Y 76. Computed Tomography and Horseradish Peroxidase Permeability: Correlation in Experimental Gliomas in Dogs Dennis R. Groothuis, Joan M . Fischer, Michael A. Mikhael, and Nicholas A . Vick, Evanston, I L 77. Cerebellopontine Angle Lipoma: A Review William Deans, Robert Shuman, Solomon Bloch, Lyal G. Leibrock, and F. Miles Skultety, Omaha, N B 78. Immune Surveillance and Brain Cancer H . Richard Beresford, J . Gregorji Cairncross, and Lloyd J . Old. Manhasset and N w York, N Y 79. Computed Tomographic Findings in Intracranial Gliosis Leon A. Weisberg, New Orleans, L A 80. Mismatch between Neuropathology Manpower and Workload: Analysis of 100 Neurology Training Centers, with Implications for Training and Research Anthony C . Breuer, William C . Schoene, andJohn P. Conomy, Cleoeland, OH, and Boston. M A 92. A Low-Molecular-Weight Demyelinating Factor in Human Serum Frederick Wougram, Los Angeles, C A 93. Serial Changes in Cognitive Components of Auditory Evoked Potentials in Dementing Illness K. Squires, T. Chippendale, and A. Starr, Imine, C A 81. Use of a Visual Evoked Potential Battery in the Evaluation of Multiple Sclerosis Stanley N.Cohen, Karl Syndulko, Edward C . Hansch, Eugene Gilden, Kenneth Phillips, and Wallace W . Tourtellotte, Los Angeles, C A 82. Evidence for the Presence of Abnormal B-Lymphocyte Clones in the Peripheral Blood of Patients with Multiple Sclerosis Stephen L. Hauser, Kenneth A. Ault, and Howard L. Weiner, Boston, M A 94. Instrumental Neutron Activation Analysis of Brain Aluminum and Other Trace Elements in Alzheimer Disease and Aging W. R. MarkeJbery, W. D . Ehmann, T . 1. M . Hosuin, M . Alauddin, and D . T . Goodin, Lexington, KY 95. Nonfamilial Olivopontocerebellar Atrophy: Clinical and CT Features L. Caplan, C . Thomas, D . Patel, I . Sherman, and T . Kemper, Chicago, IL, and Boston, M A 83. Primary Progressive Multifocal Leukoencephalopathy of the Cerebelloponti ne Type Diagnosed Premortem by Cerebellar Biopsy H . Royden Jones, E. Tessa Hedley- Whyte, Joseph E . Kelleher, and Stephen R. Friedberg, Boston, M A 96. Cerebellar Atrophy: Relationship to Aging and Cerebral Atrophy. W. C . Koller, S. L. Glatt,J . H . Fox, A. W . Kaszniak, R . S. Wilson, and M . S. Huckman, Chicago, IL 97. Epidemiological Patterns and Clinical Features of Dementia in a Defined U.S. Population Emre Kokmrn and Bruce S. Schoenberg, Rochester. M N , and Bethesda, M D 84. Myelin Proteolipid Protein in Sera and Cerebrospinal Fluid after Damage to the Central Nervous System John L. Trotter, Harish C. Agrawal, Cindy Wegerschiede,and Larry Lieberman, St. Louis, MO 85. Possible Risk Factors in Multiple Sclerosis as Found in a National Twin Study R. D . Currier and R. Eldridge. Jackson, MS, and Bethesda, M D 2;OO Simultaneous Platform Sessions C and D -4:30 86. Primacy Central Nervous System Demyelination in Ross River Virus 3:OO Coffee Break Encephalitis Alan R. Seay, J e r v S. Wolinsky, and Richard T . Johnson, Baltimore, M D -3 ;.3 0 87. Serum Immunoglobulin Levels in Guamanian Amyotrophic Lateral Sclerosis and Parkinson Disease Paul M. Hoffman, Deanna S. Robbins, Clarence J . Gibbs, Jr., and D . Carleton Gajdusek, Charleston, SC, and Bethesda, M D 88. Antibody-dependent Cytotoxicity Mediated by Normal and MS Mononuclear Cells against Isolated Cultured Glial and Neuronal Targets Roger M . Morrell, Detroit, MI 89. Fucosidosis Presenting as a Leukodystrophy Edwin H . Kolodny, Ana Sotrel, William Cable, Atilano Lacson, Michael J . Bresnan, Peter Daniel, Roger Williams, James Evans, and Allen C. Crocker, Waltham and Boston, M A 90. Plasmapheresis in Multiple Sclerosis: Correlation of Clinical Improvement with Increased Suppressor Cell Activity in Peripheral Blood Bhupendra 0. Khatri, Michael P. McQuillen, Susan M. Koethe, Clara Hussey, and A n n Cook, Milwaukee, Wl 91. Cerebrospinal Fluid Mononuclear Phagocytes and IgG-binding Mononuclear Cells in Multiple Sclerosis: Effect of Steroid Treatment B. R. Brooks, P . K. Coyle, R. L. Hirsch, S. Cohen, and R . T .Johnson, Baltimore, M D C. Chairman: David Pleasure, Philadelphia, PA Secretary: Walter G. Bradley, Boston, MA 98c. Delayed Metrizamide CT Observations in Syringomyelia H . J . M . Barnett, A. Fox, F . Vinuela, and S. J . Peerless, London. Ont, Canada 99c. Relief of Chronic, Intractable Sciatica by Dorsal Root Ganglionectomy Arthur Taub, New Haven, C T 1OOc. Studies in Familial Multiple Sclerosis G. C. Ebers and D. W. Paty, London, Ont, Canada 101c. Treatment of Multiple Sclerosis with a Synthetic Polypeptide: Preliminary Results M . B. Bornstein, A . , I . Miller, D . Teitelbauni, R. Arnon, and M . Sela, Bronx, N Y . and Rehovot, Israel 102c. Association of Autoimmune Diseases and Cellular Immune Response to the Neuritogenic Protein in Guillain-Bar& Syndrome Oded Abramsky, Isabelle Korn-Lubrtzky, and Dvora Teitelbaum,Jerusalem and Rehouot, Israel 103c. Experimental Pontine and Extrapontine Myelinol ysis Robert Laureno, Washington, DC 104c. Promotion of Microtubule Assembly by Isaxonine in Avian and Human Dystrophic Cells Jerry W. Shay, Howard Feit, and Leigh E. Thomas, Dallas, T X Program and Abstracts, American Neurological Association 87 105c. Iris Pigmentation (Melanin) in Segmental Dystonic Syndromes Including Torticollis Julius Korein, New York, N Y D. Chairman: Robert J. Joynt, Rochester, NY Secretary: Alexander G. Reeves, Hanover, N H 98d. The Tegmental Mechanism for Conjugate Eye Movement Derek Denny-Brown, Boston, M A 99d. Diagnosis of Sleep Apnea by Daytime Polysomnogram G. Browne Goode and Howard Slyter, San Francisco, CA 100d. Sleep Duration, Sleep Stages, and Waking Time Are Related to Circadian Phase in Young and Older Men during Nonentrained Conditions Elliot D . Weitzman, Charles A. Czeisler, Janet C. Zimmerman, Martin C. Moore-Ede, and Joseph M . Ronda, New York, N Y , and Boston, M A ]Old. Sleep Apnea and Hypoventilation Syndrome Associated with Acquired Nonprogressive Dysautonomia Yitzchak Frank, Richard E. Kravath, Kiyoharu Inoye, Asao Harano, Charles P. Pollak, and Elliot D . Weitzman. Bronx? N Y 102d. An Electrophysiological Study of Complex Spinal Reflexes in Brain Death Douglas B. Gersh, Leopold J . Streletz, Richard A. Chambers, and Richard G. Berry, Philadelphia, P A 103d. Apneic Facial Immersion-A Test of Vagal Function Raniesh K. Kburana, Baltimore, M D 104d. Perivascular Connections from the Trigeminal Ganglia of the Cat: A Possible Neuroanatomical Substrate for Vascular Headaches in Humans Marc Mayherg, Robert Langer, and Michael A. Moskowitz, Cambridge, M A 105d. Hydrocephalus-A Hemodynamic and Hydrodynamic Disorder D . N . White, Kingston,, Ont, Canada 4:30 Poster Session -5 :30 106. Dominantly Inherited Ataxia with Motor Neuron Disease and Abnormal Urinary Glycolipid Richard Berenberg, George Howard, and Donald H . Harter, Chicago, IL 107. Amino Acid Content of Spinal Tissue from Patients Dying of Motor Neuron Disease Bernard M. Patten, Harold M . Kurlander, and Bradley Euans, Houston, T X 108. Circulating Protease Inhibitors in Amyotrophic Lateral Sclerosis: Reduced az-Macroglobulin Barry W . Festofl. Kansas City, KS 109. Increased Sensitivity to Neuromuscular Blockade in Amyotrophic Lateral Sclerosis Ajit Chikarnzane and Barry W . FeJtofl, Kansas City, KS 88 Annals of Neurology Vol 8 No 1 July 1980 110. Familial Myasthenia with Marked Type I1 Fiber Atrophy and Negative Antibody Studies Ajit Chikamane, John Kepes, Philip A. Singer, and Barry W . Festofi, Kansas City, KS 111. Eaton-Lambert Myasthenic Syndrome: Long-term Treatment of Three Patients with Prednisone Ericb W . Streib and David A. Rothner, Omaha, N B , and Cleveland, OH 112. Pharyngoesophageal Motor Function in Patients with Myotonic Dystrophy H. M. Swick, S. L. Werlin, W . J . Dohbs, and W.J . Hogan, Milwaukee, WI 113. Muscle Mitochondrial Abnormalities in the Marinesco-Sjogren Syndrome Harold G . Marks, Frances Kelleher, Guillermo A . DeLeon, and J . Richard Bowen, Wilmington, DE, and Philadelphia, P A 114. Tibial Muscular Atrophy: Familial Syndromes of Posterior Tibial Weakness Linton C . Hopkins and Charles M . Epstean, Atlanta, GA 115. Uniform Type I Fiber Myopathy: Another Form of Nonprogressive Congenital Myopathy ? Shin Joong Oh, Birmingham, A L 116. Fibroblast Stimulating Factor (or Factors) in Neuromuscular Disease Judith B. Ulreich, Lawrence Z. Stern, and Milos Chvapil, Tucson, A 2 117. Variability of Clinical and Pathological Manifestations in Familial Fiber Type Disproportion Roger W . Kula, JGanna H . Sher, S. A. Shafiq, and Judith Hardy-Stashin, Brookhn, N Y 118. Dominantly Inherited Muscular Dystrophy with “Ragged-Red’’ Fibers and Abnormal Mitochondria Clarence Washington, Arthur Ginsberg, and S. M . Sumi, Baltimore, M D , and Seattle, W A 119. Membrane Fluorescence Studies of Dystonic Fibroblasts Jay W . Pettegrew, Nancy J . Minshew, and John S. Nichols, Dallas, T X 120. Skeletal Muscle Adaptation to Alcohol R. G. Haller, N . W . Carter, E. Ferguson, and J . P. Knochel, Dallas, T X 121. The Effect of Electrical Stimulation on Denervated Skeletal Myofibers Bruce R. Pachter, Arthur Eberstein, and Joseph Goodgold, New York, N Y 122. Introducing a New, Computer-assisted Technique for Measuring Muscle Fiber Conduction Velocities at Full Interference Pattern Israel Y a m , Mamin B. Shapiro, Andrew Mitz, and Erik W . Pottala, Bethesda, M D 123. Postpoliomyelitis Amyotrophy with Rod (Nemaline) Bodies in Skeirtal Muscle R. A . Brumback, A. F . Borge, and R. W . Leech, Fargo, N D 124. Xenograft Studies in Primary Amyloid Neuropathy Mario Kornfeld, Otto Appenzeller, and Ruth Atkinson, Albuquerque, N M 125. The Pathogenesis of Pneumatic Tourniquet Paralysis in Humans William F. Brown and Stephen K . Yates, London, Ont, Canada 126. Familial Subacute Polyradiculoneuropathy of Infancy S. M . Sumi, Cheng-Mei Shaw, and Coldevin B. Carlson, Seattle, W A 127. Value of Needle Examination versus Sensory Latencies in Carpal Tunnel Syndrome Lisa P. Trofatter and E. Wayne Massey, Durham, NC 128. In Vivo Documentation of Dysfunction in Alpha Motor Axons of Different Diameter James Domingue, B. T . Shahani, and R. R. Young, Boston, M A 129. Frequency and Type of Nerve Injury Associated with Coronary Artery Bypass Graft Surgery Richard J . Lederman, Anthony C . Breuer, Anthony J . Furlan, Maurice R. Hanson, Floyd D . Loop, Delos M . Cosgrove, and F . George Estafanous, Cleveland, OH 6 30 Cocktails and Dinner 136. Increased Blood-Brain Barrier Permeability and the Effect of Catecholamines on Cerebral Oxygen Utilization Alan A. Artru and John D. Michenfelder, Rochester, MN 137. “Crossed Cerebellar Diaschisis” in Human Supratentorial Brain Infarction J . C. Baron, M. G. Bousser, D . Comar, and P . Castaigne, Orsay and Paris, France 138. Peripheral Sympathetic Nerves Replace a Central Cholinetgic Pathway after Injury James N . Davis and Kezth A . Crutcher, Durham, N C 139. Choline Chloride in Huntington Disease Kenneth L . Davis, Leo E . Hollzster, Stephen M . Stahl, and Philip A. Berger, New York, N Y , and Stanhrd, CA 140. Enkephalins and Experimental Extrapyramidal Movement Disorders B . I. Diamond and R. L . Borison, Chicago, I L 141. New Therapeutic Forms of L-Dopa B . I. Diamond, K. S. Rajun, and R. L. Borison, Chzcago, I L 142. Amantadine and Gilles de la Tourette Syndrome R . L. Borison andJ. M . Davis, Chicago, I L 143. Muscle Pyruvate Oxidation in Spinocerebellar Degenerations Owen B. Evans, Nashville, T N Wednesday, September 10 8:OO Poster Session (continental breakfast served) -9.00 130. Digoxin-induced Cardiac Arrhythmia: Digitalization of Receptor Sites in Brainstem A. Bhagat, J . D . Mann, T . W . Furlow, Jr., H . Traurig, and N . H . Bass, Lexington, K Y , and Charlottesville, V A 131. Barbiturates and Transmitter Release at the Neuromuscular Synapse Jonathan H. Pincus and Nancy F . Insler, New Haven, C T 132. Valproic Acid Interaction with Carbamazepine G. Mattson, R. H . Mattson, a n d J . A. Cramer, West Haven, C T 133. Quantitative Measurement of Local Metabolic Rate for Glucose Utilizing Tritiated 2-Deoxyglucose Guillevmo M . Alexander, Robert Jay Schwartzman, Rodney D . Bell, Jen YE, and A n n Renthal, San Antonio, T X 134. Effect of Norepinephrine Depletion on Potassium Transport in Cerebral Cortex Thomas J . Sick, Sami 1. Harik, Joseph C . LaManna, and Myron Rosenthal, Miamt, FL 135. Dichloroacetate Stimulates Pyruvate Dehydrogenase Synthesis and Activity in Rat Liver Owen B. Evans and Peter W . Stacpoole, Nashville, TN 144. Glutamate Dehydrogenase Deficiency in Spinocerebellar Degenerations: Correlation with Adult-onset Recessive Ataxia Andreas Plaitakas, Sol1 Bed, William 0 . NicklaJ, and Melvin D . Yahr. New York, N Y 145. Portuguese Autosomal Dominant Hereditary Ataxia of Unknown Cause (“PADHAUC”) Harmeet Sachdev, Lysia Forno, and Chades A. Kune, Palo Alto and Hayward, C A 146. Derangement of Voluntary Movement in Athetosis Mark Hallett and Norbert0 Alvarez, Boston, M A 147. Isoniazid in Huntington Disease: Effect on Chorea and GABA Levels AT. V. Bala Manyarn, Leonard Katz, Theodore A. Hare, Kathryn KanaefJki, and Robert D . Tremblay, Wilmington, DE, and Philadelphia, P A 148. Treatment of Face Pain with Baclofen Gerhard H. Fromm, Chrrstopher F. Terrence, and Amrik S. Chattha, Pittsburgh, P A 149. Purine Nucleotide Metabolism in Myoadenylate Deaminase Deficiency Tetsuo Ashizawa, Bernard M . Patten, and Rzchard L. Sabina, Hoaston, T X , und Durham, N C 150. Altered Muscle Polyamine Levels in Human Neuromuscular Diseases Anna M . Kaminska, Lawrence Z . Stern, Joanne S. Finch, and Diane H . Russell, Tucson, AZ Program and Abstracts, American Neurological Association 89 151. Chondrodystrophic Dwarfism w i t h Continuous Muscle Fiber Activity (Schwartz-Jampel Syndrome): Description of Additional Abnormalities K. Engebretson, W. H . Olson, G. G. Gascon, and R. A. Brumback, Fargo, N D 152. Trismus: A New Sign in Polymyositis Ajit Chikarmane, Philip A. Singer, and Barry W. Festoff; Kansas City, KS 153. Illusions of Supernumerary Limbs i n Myelopathy Judith Capraro, Lawrence Jacobs, William McHugh, and Svend Gdthgen, Bufialo, N Y 154. Characterization of Altered Neuronal Proteins i n Alzheimer Disease D . J . Selkoe, F. J . Salazur, B. A. Brown, and C. A. Marotta, Belmont, MA 9.00 The Foster Ettling Bennett Memorial Lecture -1 0:OO Receptors i n the Brain Solomon H . Snyder, Bahimore, M D 1O:OO Coffee Break -10~30 10:30 Symposium on Neuropeptides -12:30 Chairman: Earl A, Zimmerman, New York, N Y Participants : Earl A. Zimmerman, Peptide Pathways in the Central Nervous System Robert L. MacDonald, Peptides as Neurotransmitters Wylie Vale, Peptide Analogs: Future Therapeutic Implications Alan I. Faden, The Role of Endorphins in Shock and Spinal Cord Injury: Clinical Implications Abstracts la. Positron Imaging of the Normal Brain-Functional Asymmetries S. Finklestein, N. A. Alpert, R. H . Ackerman, F . S. Buonanno, J . A. Correid,J. Chang, S. Kulas, and G. L. Brownell, Boston, MA Positron images in 14 awake normal right-handed subjects indicate functional asymmetries in cerebral blood flow (CBF) and metabolism. Transverse section imaging permits investigation of physiology in deep as well as superficial structures. Studies of CBF (14 subjects) and oxygen metabolism (11 subjects) were obtained in resting volunteers during continuous inhalation of Cl5O, and l5OZ, respectively. Two of these subjects also had studies of glucose metabolism following intravenous injection of "FDG. Qualitative images were examined in all subjects. In 3, quantitative values for flow and metabolism were obtained. Cerebral blood flow and metabolism were coupled in all brain regions. Oxygen metabolism was coupled to glucose metabolism in subjects in whom this was studied. In all subjects, flow and metabolism were greater in the occipital than in the parietooccipital cortical regions and in the inferomedial frontal than in the lateral frontal cortical regions. In 8 of the 14 subjects there was evidence of greater flow and metabolism in the dominant frontotemporal region compared to the corresponding nondominant region. In no subject was the converse true. Positron images in 90 Annals of Neurology Vol 8 No 1 July 1980 subjects with diseased brains must be interpreted in light of asymmetries found in normal resting individuals. 2a. Selective Necrosis i n t h e Central Nervous System-Histopathological Observations in the Macaque Monkey following Transient Focal Cerebral Ischemia U.DeGirokdmi, R. M. Crowell, and F . W . Marcoux, Worcester,Boston, and Burlington, M A Forty unanesthetized macaque monkeys underwent reversible middle cerebral artery occlusion via a previously implanted transorbital snare ligature. Focal cerebral ischemia, followed by reperfusion, was instituted for periods of 15 minutes to four hours. Animals were sacrificed by intracardiac formalin perfusion two weeks later. Brains were embedded in celloidin and serially cut horizontally, and sections at 3.75 mm intervals were sained with hematoxylin and eosin, cresyl violet, and Loyez. The following generalizations summarize our results: (1) in comparison with our previous studies using the same protocol and longer periods of occlusion, reduction of the duration of occlusion below four hours results in a decrease in the size and change in the distribution of the lesion: shorter occlusion times involve deep structures and spare the cortex; (2) gray and white matter have different susceptibilities to ischemia: as the duration of occlusion is decreased, the white matter is less vulnerable to infarction than the gray; and (3) within the gray matter, gradients to ischemic injury exist: neurons (small) and pericapillary tissues seem most sensitive. This study presents histological evidence of selective necrosis presumed to be due to selective vulnerability in experimentally induced ischemia. (Supported by Grant NS10828 from NINCDS.) 3a. Local Metabolic Responses in Brain Accompanying Motor Activity C. Kennedy, M . Miyaoka, S. Suda, K. Macko, C.Jawis, M . Mishkin, and L. Sokolofi, Bethesda, M D Alterations in neuronal activity have been shown to be accompanied by corresponding changes in rates of glucose utilization. We employed the ['4Cldeoxyglucose method to determine the magnitude of such changes in the niotor, somatosensory, and cerebellar pathways of rhesus monkeys during the performance of a task that required reaching toward and pressing plastic keys. Unilateral arm and hand movements were executed approximately forty times per minute throughout a 45-minute experimental period. Rates of glucose utilization were measured at all levels of the neuraxis in four working and four inactive monkeys. No consistent right-left differences were found in any structure in the inactive animals. In working animals, unilateral increments varying up to 50% were found in the following structures: laminae I through IX of the cervical cord, the cuneate nucleus, the lateral reticular nucleus, crus I1 of the cerebellum, the red nucleus, the ventral posterolateral nucleus of the thalamus, part of the globus pallidus, and discrete portions of the posterior parietal, somatosensory, primary, premotor, and supplementary motor cortices. The study revealed that more energy is expended in somatosensory monitoring and cerebellar control systems than in the primary motor system itself during repetitive arm and hand movements.