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УAssociation study of a functional promoter polymorphism in the XBP1 gene and schizophrenia Ф American Journal Of Medical Genetics Part B (Neuropsychiatric Genetics) 141B 71Ц75 (2006).

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American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 141B:430 –432 (2006)
Erratum
‘‘Association Study of a Functional Promoter Polymorphism
in the XBP1 Gene and Schizophrenia,’’ American Journal
Of Medical Genetics Part B (Neuropsychiatric Genetics)
141B:71–75 (2006)
Erik G. Jönsson,1 Sven Cichon,2,3 Johannes Schumacher,2 Rami Abou Jamra,2 Thomas G. Schulze,4
Monica Deschner,4 Kaj Forslund,1 Håkan Hall,1 Peter Propping,2 Piotr M. Czerski,5 Monika Dmitrzak-Weglarz,5
Pawel Kapelski,5 Martin Driessen,6 Wolfgang Maier,7 Joanna Hauser,5 Marcella Rietschel,4
and Markus M. Nöthen2,3
1
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
Institute of Human Genetics, University of Bonn, Bonn, Germany
3
Life & Brain Center, University of Bonn, Bonn, Germany
4
Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
5
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
6
Department of Psychiatry, Gilead Hospital, v. Bodelschwingsche Anstalten Bethel, Bielefeld, Germany
7
Department of Psychiatry, University of Bonn, Bonn, Germany
2
Please cite this article as follows: Jönsson EG, Cichon S,
Schumacher J, Jamra RA, Schulze TG, Deschner M,
Forslund K, Hall H, Propping P, Czerski PM, DmitrzakWeglarz M, Kapelski P, Driessen M, Maier W, Hauser J,
Rietschel M, Nöthen MM. 2006. ‘‘Association Study of a
Functional Promoter Polymorphism in the XBP1 Gene
and Schizophrenia,’’ American Journal Of Medical
Genetics Part B (Neuropsychiatric Genetics) 141B:71–
75 (2006). Am J Med Genet Part B 141B:430–432.
In the January 2006 issue, ‘‘Association study of a functional
promoter polymorphism in the XBP1 gene and schizophrenia’’
pages 71–75, the authors of the article express their regret of a
nomenclature error of substantial nominal impact. In the
report the C and G alleles in the three European samples
should be changed, so that C is replaced by G and vice versa.
This means that the allele frequency pattern is almost inversed
as compared to the Asian populations (Tables I–III). This
would give rise to the following changes: within the European
DOI 10.1002/ajmg.b.30333
ß 2006 Wiley-Liss, Inc.
samples the only nominal association detected and reported,
that is, the one between schizophrenia and the G/G genotype
among Swedish men, should be between schizophrenia and the
C/C genotype. Otherwise, as previously reported no significant
differences were detected within the European samples.
For the correct meta-analyses, see Tables I–III supplemented here. We previously reported a borderline significant
association between G containing genotypes and schizophrenia in the meta-analysis of the total samples. This
association is not significant after the allele correction of
the European samples (Table I, h), whereas comparisons of
alleles now give rise to a borderline significant association
between the G allele and the disorder (Table I, i; OR ¼ 1.11,
95% CI 1.01–1.23). This association, however, is to a major
extent based on the Asian samples, as removing any of the
Asian studies from the analysis yields a non-significant result.
As before, no associations were detected when meta-analyseswere performed for each gender separately (Tables II and
III).
Poznan, Poland;
Caucasian
Stockholm, Sweden,
Caucasian
Present study
Present study
234
451
374
371
608
822
555
816
273
282
122
134
950
1,232
1,558
2,054
Controls
Patients
Controls
Patients
Controls
Patients
Controls
Patients
Controls
Patients
Controls
Patients
Controls
N
Patients
Controls
Patients
Subject
category
19
39
15
64
27
45
144
106
191
178
G/G
55
117
43
349
131
258
173
111
195
148
G/C
OR, odds ratio; CI, confidence interval.
a 2
w ¼ 5.20, degree of freedom (df) ¼ , P < 0.05. Heterogeneity w2 ¼ 1.18, df ¼ 1, not significant (NS).
b 2
w ¼ 4.64, df ¼ 1, P < 0.05. Heterogeneity w2 ¼ 3.02, df ¼ 1, NS.
c 2
w ¼ 7.97, df ¼ 1, P < 0.01. Heterogeneity w2 ¼ 0.00, df ¼ 1, NS.
d 2
w ¼ 0.71, df ¼ 1, NS. Heterogeneity w2 ¼ 1.56, df ¼ 2, NS.
e 2
w ¼ 1.05, df ¼ 1, NS. Heterogeneity w2 ¼ 2.92, df ¼ 2, NS.
f 2
w ¼ 0.16, df ¼ 1, NS. Heterogeneity w2 ¼ 2.65, df ¼ 2, NS.
g 2
w ¼ 1.77, df ¼ 1, NS. Heterogeneity w2 ¼ 6.87, df ¼ 4, NS.
h 2
w ¼ 3.58, df ¼ 1, NS. Heterogeneity w2 ¼ 8.06, df ¼ 4, NS.
i 2
w ¼ 4.38, df ¼ 1, P < 0.05. Heterogeneity w2 ¼ 6.40, df ¼ 4, NS.
Total
Total European
Bonn, Mannheim,
Germany; Caucasian
Shanghai, China;
Han Chinese
Present study
Total Asian
Chen et al. [2004]
Kakiuchi et al. [2004] Tokyo, Japan; Japanese
References
Subject residence;
ethnicity
60
126
64
403
115
252
54
17
65
48
C/C
Genotype (counts)
0.66–1.18
0.95–1.34
1.12g
0.41–1.75
0.41–1.15
0.70–1.54
1.04-1.59
1.07–1.92
0.82–1.55
95% CI
0.88d
0.85
0.68
1.04
1.28a
1.43
1.13
OR
G/G versus (G/
C þ C/C)
1.16h
1.09e
0.73
1.11
1.17
1.44b
1.16
2.15
OR
0.99–1.35
0.92–1.30
0.45–1.20
0.79–1.55
0.95–1.46
1.03–2.02
0.76–1.76
1.23–3.76
95% CI
(G/G þ G/C) versus
C/C
TABLE I. XBP1-116 C/G Polymorphism and Schizophrenia: Meta-Analysis of Association Studies
35
35
30
29
34
31
62
69
64
67
OR
1.11i
1.03f
0.80
0.97
1.11
1.26c
1.26
1.25
95% CI
G versus C allele
1.01–1.23
0.90–1.17
0.55–1.17
0.76–1.24
0.94–1.31
1.07–1.47
1.02–1.56
0.99–1.59
Patients
Controls
Patients
Controls
Patients
Controls
Patients
Controls
Patients
Controls
Patients
Controls
Subject category
Patients
Controls
Patients
Controls
Patients
Controls
Patients
Controls
Patients
Controls
Patients
Controls
Subject category
307
411
160
109
75
73
542
593
224
197
766
790
N
w ¼ 0.39, df ¼ 1, NS. Heterogeneity w2 ¼ 0.35, df ¼ 2, NS.
w ¼ 0.98, df ¼ 1, NS. Heterogeneity w2 ¼ 8.06, df ¼ 2, P < 0.02.
c 2
w ¼ 0.21, df ¼ 1, NS. Heterogeneity w2 ¼ 4.46, df ¼ 2, NS.
d 2
w ¼ 1.54, df ¼ 1, NS. Heterogeneity w2 ¼ 4.92, df ¼ 3, NS.
e 2
w ¼ 1.26, df ¼ 1, NS. Heterogeneity w2 ¼ 8.07, df ¼ 3, P < 0.05.
f 2
w ¼ 2.16, df ¼ 1, NS. Heterogeneity w2 ¼ 6.64, df ¼ 3, NS.
b 2
a 2
Total
Chen et al. [2004]
Present study, total
Present study, Sweden
Present study, Poland
Present study, Germany
References
248
405
113
173
47
61
408
639
150
174
558
813
N
69
71
18
26
9
23
6
10
G/G
63
79
108
176
57
77
21
20
G/C
18
24
122
203
47
73
20
31
C/C
0.80–1.92
0.75–1.41
1.03d
0.54–1.33
0.85a
1.24
0.24–2.17
0.25–1.27
0.61–2.13
95% CI
0.73
0.56
1.14
OR
G/G versus
(G/C þ C/C)
1.08e
1.17
1.06b
1.33
1.03
1.04
OR
0.85–1.36
0.61–2.26
0.83–1.36
0.62–2.84
0.63–1.66
0.76–1.42
95% CI
(G/G þ G/C) versus C/C
67
64
29
28
33
36
34
33
G allele frequency (%)
109
73
27
38
18
16
9
9
G/G
85
94
150
173
74
40
40
35
G/C
30
30
130
200
68
53
44
29
C/C
Genotype (counts)
a
1.19
d
1.61
0.88
0.97
0.74v
0.94
OR
0.90–1.57
1.09–2.38
0.60–1.30
0.36–2.60
0.36–1.52
0.56–1.59
95% CI
G/G versus
(G/C þ C/C)
1.13
1.16
e
b
1.13
0.46
1.28v
1.29
OR
0.91–1.41
0.67–2.01
0.89–1.43
0.24–0.90
0.79–2.09
0.96–1.74
95% CI
(G/G þ G/C)
versus C/C
68
61
33
30
34
33
27
36
G allele frequency (%)
TABLE III. XBP1-116 C/G Polymorphism and Schizophrenia in Men: Meta-Analysis of Association Studies
w ¼ 0.50, df ¼ 1, NS. Heterogeneity w2 ¼ 1.92, df ¼ 2, NS.
w ¼ 0.23, df ¼ 1, NS. Heterogeneity w2 ¼ 0.37, df ¼ 2, NS.
c 2
w ¼ 0.01, df ¼ 1, NS. Heterogeneity w2 ¼ 0.58, df ¼ 2, NS.
d 2
w ¼ 0.03, df ¼ 1, NS. Heterogeneity w2 ¼ 3.26, df ¼ 3, NS.
e 2
w ¼ 0.38, df ¼ 1, NS. Heterogeneity w2 ¼ 0.45, df ¼ 3, NS.
f 2
w ¼ 0.28, df ¼ 1, NS. Heterogeneity w2 ¼ 1.16, df ¼ 3, NS.
b 2
a 2
Total
Chen et al. [2004]
Present study, total
Present study, Sweden
Present study, Poland
Present study, Germany
References
Genotype (counts)
TABLE II. XBP1-116 C/G Polymorphism and Schizophrenia in Women: Meta-Analysis of Association Studies
0.89–1.23
0.84–1.61
0.83–1.22
0.63–1.96
0.63–1.28
0.82–1.34
95% CI
f
1.12
1.34
1.04
c
0.63
1.06
1.14
OR
0.96–1.30
1.01–1.78
0.87–1.25
0.39–1.04
0.74–1.53
0.91–1.43
95% CI
G versus C allele
1.05f
1.17
1.01c
1.11
0.90
1.04
OR
G versus C allele
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journal, neuropsychiatry, 141b, 71ц75, уassociation, promote, part, polymorphism, stud, xbp1, genes, american, medical, function, genetics, schizophrenia, 2006
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