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Mycoplasma hyorhinis swine arthritis.

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Mycoplasma Hyorhinis Swine Arthritis
We have had several letters about finding high
synovial Buid titers in the metabolic inhibition test
for Mycoplasma hyorhinis in swine arthritis (1).
In. a few animals these exceeded serum titers and
we said, “Greater synovial fluid titers of antibody
to a microorganism has not, to our knowledge,
been reported in other forms of articular disease.”
Since the point is of interest, we are pleased to
report that our knowledge has been upgraded. Dr.
Harold Clark pointed out an abstract report of a
study of complement fixing antibodies to several
human mycoplasma in arthritic patients; he and
his associates found this activity was frequently
higher in rheumatoid synovial fluids than in simultaneous serum samples (2)
Dr. Dennis Sikes produced a substantial arthritis
in swine given repeated transfusions of sterile whole
blood taken from animals with chronic Erysipelothrix insidiosa arthritis. Titers of E insidiosu agglutinating activity were much lower in the recipients than in the donors. In one of the recipients,
joint fluid antibody titers were greater than in the
serum. The organism was not recovered from the
recipient swine (3).
Dr. David Berman, also working with E insidiosa
of swine, distinguished histologically between “normal” (normal, healing or healed) and “acute”
joints (4). The synovial fluid from the normal
joints showed substantially lower titers of antierysipelothrix agglutinins than did simultaneous serum
samples but serum and fluid from acute joints
showed approximately equal titers. Since the protein content of the acute synovial fluid was lower
than that of serum, the antibody activity per milligram of protein was higher in the fluid. E insidiosa
was recovered from several of the “acute” joints (5).
If one accepts the notion that the presence of a
chronic antigenic stimulus best explains the complex histologic picture of rheumatoid synovitis, the
above reports should stimulate further comparisons
of the antibody activities of serum and synovia in
rheumatoid arthritis.
1. Barden JA, Decker JL: Mycoplusma hyorhinis
swine arthritis. I. Clinical and microbiological
features. Arthritis Rheum 14:193-201, 1971
2. Brown TM, Bailey JS, Felts WR, et al: Mycoplasma antibodies in synovia. Arthritis Rheum
9:495, 1966
3. Sikes D, Fletcher 0 Jr, Papp E: Further studies
on the pathologic alterations of tissues of swine
given repeated whole blood transfusions from
swine with rheumatoid-like arthritis. Amer J Vet
Res 28:1413-1425, 1967
4. Timoney JF Jr, Berman DT: Erysipelothiix
arthritis in swine: serum-synovial fluid gradients
for antibody and serum proteins in normal and
arthritic joints. Amer J Vet Res 31:1405-1409,
5. Timoney JF Jr, Berman DT: Erysipelothrix
arthritis in swine: bacteriologic and immunopathologic aspects. Amer J Vet Res 31:14111421, 1970
Arthritis and Rheumatism, Vol. 14, No. 6 (November-December 1971)
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arthritis, mycoplasma, swing, hyorhinis
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