Systemic autoimmunity. Immunology Series Volume 54. Edited by Pierluigi E. Bigazzi and Morris Reichlin. New York Marcel Dekker 1991. 300 pp. Illustrated. Indexed. 149.50код для вставкиСкачать
1255 BOOK REVIEWS Handbook of Drug Therapy in Rheumatic Diseases. Joseph G. Hardin, Jr., Gesina L . Longenecker. Boston, Little Brown, & C o . , 1992. 256 p p . Illustrated. Indexed. $29.50. This is a conveniently sized handbook apparently targeted for practical use in the treatment of patients. It is divided into sections according to the conventional groupings of drugs (nonsteroidal antiinflammatory drugs [NSAIDs], corticosteroids, slow-acting antirheumatic drugs [SAARDs], and drugs for gout); it also includes a section on specific therapy for the more common rheumatic diseases. The book is adequately, though not exhaustively, indexed. The handbook has some real and gratifying strengths. Specifically, it presents an an up-to-date overview of knowledge about the mechanism(s) of action of the antirheumatic drugs in a clear, concise way, without venturing into speculation. The discussion of rheumatoid arthritis (RA) treatment is quite good, although it does not mention the current controversy about inverting the RA treatment pyramid. Unlike many other publications, this book addresses the financial burden involved with antirheumatic drug therapy (particularly with respect to the SAARDs). As RA is the prototypic rheumatic disease, its treatment is carefully and completely outlined. The book is less specific, helpful, and comprehensive in describing treatment of other rheumatic diseases (e.g., Raynaud's phenomenon, other connective tissue diseases, and degenerative joint disease). While an explanation for this shortcoming may be that less good data are available, the contrast with the thoroughness of the coverage of RA is nevertheless evident. Furthermore, the discussion on adverse reactions to NSAIDs could have benefited from more data and more emphasis on how to avoid adverse reactions (and how to treat them if they occur). Overall, I believe Handbook of' Drug Thercrpy in Rheumatic Diseases has a place in the early teaching about the treatment of rheumatic diseases, with the clear understanding that it represents the beginning, not the middle or end, of the curriculum. Daniel E. Furst, MD Virginia Mason Research Center Seattle, WA Systemic Autoimmunity. Immunology Series, Volume 54. Edited by Pierluigi E. Bigazzi and Morris Reichlin. Neu, York, Marcel Dekker, 1991. 300 p p . Illustrated. Indexed. $149.50. Autoimmune diseases have historically been classified as systemic or organ specific, according to the pattern of pathologic involvement. While this distinction retains its clinical utility, its relevance for understanding disease pathogenesis has diminished. Indeed, research on most autoimmune diseases, irrespective of classification, is now being approached using a remarkably coherent set of experimental paradigms. To review this research as it applies to the Arthritis and Rheumatism, Vol. 35, No. 10 (October 1992) connective tissue diseases, Drs. Pierluigi E. Bigazzi and Morris Reichlin have assembled Systemic Autoimmunity. The volume provides detailed descriptions of immunologic features of diseases such as systemic lupus erythematosus, Sjogren's syndrome, and polymyositis; these diseases are denoted as systemic autoimmune diseases, in contrast to neurologic and endocrine diseases, which are considered organ specific. The book consists of 10 chapters, 5 on pathogenesis and 5 on specific diseases, all written by leaders in the field. The focus is primarily on autoantibodies and the role of genes of the HLA complex in determining their expression and specificity. The discussion of clinical issues is more limited, although relevant material for the practitioner is included in each chapter. The chapters on the specific diseases are, in general, outstanding, and contain a wealth of useful information on clinical immunology, as well as comprehensive reference lists. Although the chapters on pathogenesis are expertly written, as a group they are perhaps less successful. This situation reflects problems in distilling, from the large and emerging body of literature on autoimmunity, the most relevant material for presentation. Thus, topics such as pathways of B and T cell activation, T cell receptor utilization, and murine autoimmunity would have all benefited from more extensive coverage. Since no single volume can encompass all facets of this dynamic field, these considerations in no way diminish appreciation for this scholarly and carefully crafted work. Systemic Autoimmunity can be recommended for clinicians as well as researchers interested in the most recent information on autoantibody responses in the connective tissue diseases. The purchase price, however. may limit its acquisition for personal libraries. David S. Pisetsky, MD, PhD Department of Veterans Affairs, Medical Center Durhmm. NC Receptors of Inflammatory Cells: Structure-Function Relationships. Cellular and Molecular Mechanisms of Inflarnmation. Volume I . Edited by Charles G. Cochrane and Michael A . Girnbrone. San Diego, Academic Press, 1990. 255 p p . Illustrcited. Indexed. $49.95. Inflammation is fundamental to defense mechanisms of higher organisms and is a hallmark of many diseases that affect humans. Understanding the basic mechanisms of the inflammatory process is therefore an important goal in both basic biology and applied medicine. At the cellular level, each phase of inflammation, such as the recruitment of inflammatory cells and their activation, with subsequent elaboration of various mediators, involves interaction between specific ligands and their cognate receptors. Recent advances in biochemistry and molecular biology have resulted in a profusion of literature on basic mechanisms of ligand-receptor interactions. The first volume of the series Cellular and Molecular Mechanisms of Inflammation brings together these latest advances with specific relevance to inflammation.