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The human vomeronasal organ. V. An interpretation of its discovery by Ruysch Jacobson or K├╢lliker with an English translation of K├╢lliker (1877)

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THE ANATOMICAL RECORD (PART B: NEW ANAT.) 270B:4 –15, 2003
ARTICLE
The Human Vomeronasal Organ. V. An Interpretation
of Its Discovery by Ruysch, Jacobson, or Kölliker,
With an English Translation of Kölliker (1877)
KUNWAR P. BHATNAGAR*
AND
TIMOTHY D. SMITH
The vomeronasal organs (VNOs) of mammals are highly variable epithelial structures found bilaterally in the mucosa
of the nasal septum. Whereas the discovery of the human VNO is traditionally ascribed to Frederick Ruysch (1703,
1724), the organ is named after Ludwig Levin Jacobson (1811, 1813) who described it in nonhuman mammals. We
recently have pointed out controversies surrounding the incidence and structure of the enigmatic human VNO, and
herein, we provide a historical analysis of its discovery. We present evidence that the honor of discovering the human
VNO truly belongs to Kölliker (1877), and not to Ruysch. Ruysch illustrated the lateral view of a 2-year-old infant’s
nasal septum, and it is unclear whether the right nasal passage, the tubular VNO or its opening, or an unrelated duct
is being indicated. Jacobson reported the VNO to be missing in humans. Its discovery in the human embryo can be
related in part to later authors, such as Dursy (1869). Our reappraisal of the literature confirms that Kölliker was
actually the first among these 18th–19th century investigators to provide evidence of the human VNO as a
histologically identifiable structure in the fetus and the adult. Anat Rec (Part B: New Anat) 270B:4 –15, 2003.
© 2003 Wiley-Liss, Inc.
KEY WORDS: Dursy; human; Jacobson; Kölliker; Ruysch; Sömmering; vomeronasal organ; VNO; history; translation;
chemosensory
INTRODUCTION
Most mammals possess bilateral chemosensory structures found in the nasal septal mucosa, called vomeronasal
organs (VNOs). These structures are
exceedingly variable in primates
(Smith et al., 2001a), and even humans possess a nonchemosensory homologue (Bhatnagar and Smith,
2001). Historically, Frederick Ruysch
(1638 –1731, Fig. 1a), a Dutch anatomist, has been universally and unquestionably associated with the discovery of the human VNO. In the
Dr. Bhatnagar is a Professor in the Department of Anatomical Sciences and
Neurobiology, University of Louisville
School of Medicine. He has studied chemosensory systems for more than 30
years with a special emphasis on the
human/mammalian vomeronasal system. His other research interests include human development, pineal gland
structure and function, and biology of
bats. Dr. Smith is an Associate Professor in the School of Physical Therapy,
Slippery Rock University, where he
teaches gross anatomy, histology, and
embryology. He is also an Adjunct Research Associate Professor in the Department of Anthropology, University of
Pittsburgh, where he received a Ph.D. in
Physical Anthropology. His research in-
© 2003 Wiley-Liss, Inc.
human, the organ is quite unlike that
in other vertebrates (see Bhatnagar
and Meisami, 1998; Meisami and
Bhatnagar, 1998). Instead of exhibiting clear evidence of chemosensory
function seen in most other vertebrates, the human homologue of the
VNO has no clear evidence for chemoreception (see Smith et al., 2001a, for
definitions of the vomeronasal complex) and may have other unrelated
functions (Bhatnagar and Smith
2001; Smith et al., 2001a).
The VNO of mammals in general
terests include craniofacial growth and
development, and he has a specific focus on functional histology and evolution of the mammalian vomeronasal organ. Both Dr. Smith and Dr. Bhatnagar
are Research Associates in the Carnegie
Museum of Natural History, Pittsburgh.
*Correspondence to: Kunwar P. Bhatnagar, Ph.D., Department of Anatomical
Sciences and Neurobiology, University
of Louisville School of Medicine, Louisville, KY 40292. Fax: 502-852-6228;
E-mail: bhatnagar@louisville.edu
DOI 10.1002/ar.b.10001
Published online in Wiley InterScience
(www.interscience.wiley.com).
(but not of humans) was discovered
by Jacobson (1811, 1813). That the
human VNO was discovered by Ruysch (1703), 108 years earlier, has been
repeated to the present date (see
Takami, 2002, p. 245) and never before questioned or investigated. More
so, it is interesting that Ruysch himself did not give a name to the organ,
which awaited its first description until 1811. Ruysch only presented the
right lateral view of a 2-year-old
child’s nasal septum in an illustration
with structures labeled (Figure 1b),
several of which having no comparable morphological features to those on
a septum we examined from the same
age group (Figure 1d). To assign Ruysch as the discoverer of the human
VNO misinterprets historical facts.
We intend to set the record straight
concerning discovery of the human
VNO and to grant credit where credit
is due.
There has been a distinguished list
of authors who began to mention the
human VNO, at least briefly, before
and after its monographic treatment
in mammals by Jacobson (1811,
1813). Ruysch (1703) and Sömmering
ARTICLE
THE ANATOMICAL RECORD (PART B: NEW ANAT.) 5
Figure 1. a: Frederick Ruysch (1638 –1731), from a painting by Jurriaan Poole in the Museum
Boijmans Van Beuningen, Rotterdam. Reproduced by permission of the Museum. b: The
nasal septum of a 2-year-old infant as published in Ruysch (1703, page 70; see Bhatnagar
and Reid, 1996). c: The septum in b reconstructed by the authors. The septum is rotated 90
degrees counterclockwise and cross-sectioned to show where the vomeronasal organ
(vno) is actually located relative to the paraseptal cartilage (pc), nasal septum (ns), and
nasal cavity (nc). On the left side the septum, the possible location of the openings of
Ruysch’s “nasal canal” is indicated (asterisk). d: The nasal septum of a 2-year-old infant
examined in a previous study by Bhatnagar and Smith (2001), positioned similarly for
comparison with Figure 1b. The actual position of the vomeronasal organ in this septum was
verified by serial sections and is indicated by a bracket. Note the apparently more superior
position compared with the openings indicated in b. The scale is a millimeter ruler. d is
reprinted by permission of Cambridge University Press. [Color figure can be viewed in the
online issue, which is available at www.interscience.wiley.com.]
(1809) each illustrated the lateral view
of a human nasal septum in a child
(Figure 1b) and adult (Figure 2b), respectively, although they did not show
the VNO itself (which is submucosal
in location, Bhatnagar and Smith,
2001). On the human condition, Jacobson (1811) clearly mentioned
“. . .in the monkeys it becomes so
small that we are prepared to see it
vanish completely in man.” (See English translation by Bhatnagar and
Reid, 1996, p 228.) Of interest, this
statement is nearly accurate when relying on a gross observational perspective—VNOs can be quite small in
anthropoid primates in general
(Smith et al., 2001a) and are only visible by microscopy in humans (Bhatnagar and Smith, 2001). Gratiolet
(1845) and Dursy (1869) made brief
remarks about the human VNO. Finally, Professor Rudolf Albert von
Kölliker (1877) provided the first detailed histological description of the
human VNO in the fetus and adult. He
offered 10 figures in two plates demonstrating the VNO. Kölliker’s contribution has been acknowledged by
very few in the field. In our opinion,
his monograph is as critical as the
findings of Ruysch and Jacobson.
Considering its importance, we are
providing a verbatim translation of
the original German text by Kölliker
(1877) to make its availability within
easy reach of English-speaking investigators.
As a postscript to Kölliker’s work, it
took over a century for further serious
enquiry into the human VNO, even
though there are sparse considerations of the structure in the interim
(e.g., Ishimitsu, 1958). The most detailed consideration of the development and adult structure of the human VNO has only occurred within
approximately the past two decades
(Kreutzer and Jafek, 1980; Johnson et
al., 1985; Ortmann, 1989; Smith et al.,
1997; Smith and Bhatnagar, 2000;
Trotier et al., 2000; Bhatnagar and
Smith, 2001; Witt et al., 2002). In a
series of papers, we have endeavored
to provide a perspective on history
(Bhatnagar and Reid, 1996), development (Smith and Bhatnagar, 2000),
functional morphology (Bhatnagar
and Smith, 2001), and topography
(Bhatnagar et al., 2002) of the human
VNO. Whereas this series began with
a discussion of the well-known contributions of Ruysch and Jacobson, the
present work discusses the lesser
known but definitive discoveries by
Kölliker (1877).
As of this writing, translations of relevant passages by Ruysch (1703, 1724),
Jacobson (1811, 1813), and Kölliker
(1877) are all available in English for
learned scholars to reach their own
conclusions. A partial time-line for the
years between 1703 and 2002 is provided in Table 1. This details significant
early findings on the human VNO and
uses our contributions for a more recent perspective. This report analyzes
the historical literature on the human
VNO, encompassing the work that we
Professor Rudolf Albert
von Kölliker (1877)
provided the first
detailed histological
description of the
human VNO in the fetus
and adult. Kölliker’s
contribution has been
acknowledged by very
few in the field.
have presented recently (see Table 1
and Bhatnagar and Reid, 1996). Our
previous work on dissection of a nasal
septum of a 2-year-old child was also
compared with the same aged septa examined by Ruysch (1703), an important
comparison, because our specimen has
also been mapped by means of serial
sections to relate to the gross morphology (Bhatnagar and Smith, 2001).
OBSERVATIONS AND
COMMENTS
Ruysch’s Contributions (1703,
1724)
Ruysch (Figure 1a) published a description of his collections and preparations in a 10-volume set, Thesaurus
Anatomicus (see Lindeboom, 1980). It
6 THE ANATOMICAL RECORD (PART B: NEW ANAT.)
ARTICLE
TABLE 1. Historical time-line related to the discovery of the human vomeronasal organ (VNO)
Year of
Report
1703
1809
1811
1838
1845
1869
1877
2000a
2001
2002
Relevant Findings
Reference
“Longitudinal dissection” through the nasal septal region
of an infant
Lateral view of an adult human nasal septum showing a
probe entering “Jacobson’s organ” (which was yet to
be histologically identified)
“. . . it is most developed in the rodents, next in the
ruminants. The carnivores have less, and in the monkeys
it becomes so small that we are prepared to see it
vanish completely in man.”
Jacobson’s organ arises as an invagination of the
olfactory mucous membrane, and the organ becomes
differentiated from this invagination
This work has importance for the VNO in mammals in
general, but the author does not specifically address
the human VNO
Several human VNOs were examined; the author used
the name “Jacobson’s organ” (sic), but there are no
illustrations
Provided the histological description of the VNO,
illustrated for the first time, in prenatal and postnatal
humans; he called it Jacobson’s organ, and noted that
it is homologous to that of other animals; he also
named Jacobson’s (paraseptal) cartilages
Prenatal presence of the human VNO is examined from
33 days fertilization age to near-term; the VNO appears
to lose receptor cells during early fetal development,
and a nonsensory remnant persists during the
remainder of prenatal development
The consistent presence of the VNO is recorded as a
homolog to that of other mammals, in a simplified ductlike form in the nasal septum; extremes of size
variability, bilateral asymmetry, nonchemosensory
pseudostratified ciliated epithelium is noted; serial
histological sectioning is identified as the only means of
locating and identifying the human VNO with absolute
certainty
Nasopalatine recess, nasopalatine fossa, septal mucosal
pits, the VNO and VNO opening were histologically
distinguished; it was emphasized that the human VNO
can only be identified by serial sectioning
Ruysch (1703) as translated by
Bhatnagar and Reid, 1996
Sömmering (1809) as cited by
Pearlman (1934)
Jacobson (1811), a report by
Cuvier (translated by
Bhatnagar and Reid (1996)
Rathke (1838). See Bhatnagar
and Reid (1996)
Gratiolet (1845)
Dursy (1869)
Kölliker (1877)
Smith and Bhatnagar (2000)
Bhatnagar and Smith(2001)
Bhatnagar et al. (2002)
a
A gap in the literature from 1878 to 1999 is purposely left, for the sake of brevity, in which the presence vs. absence and
homology of the human VNO is debated. For a more complete assessment of studies occurring between 1980 and 1999, see
Smith and Bhatnagar (2000), Bhatnagar and Smith (2001), and Smith et al. (2001a).
is quite probable that Ruysch’s preparations, including that of the now-famous nasal septum of an infant (Figure 1b), might still be available
somewhere for inspection. His collection was purchased in 1717 by Peter
the Great for 30,000 guilders (Lindeboom, 1980, p 41). Most certainly,
Ruysch was the first to illustrate and
remark on the nasal septum of a
2-year-old infant. The age of this cadaver is confirmed from Ruysch’s own
writing and from a painting by Jurriaan Pool that is held in the collection
of Museum Boijmans Van Beuningen,
Rotterdam (Löwensteyn, 2000). The
painting depicts Ruysch dissecting a
child. A later, often repeated extrapolation states that Ruysch described
the nasal septum of a soldier who received a facial wound (Kauer, 1969,
cited in Monti-Bloch et al., 1998;
Wysocki, 1979), but this is not related
to his description of the nasal canals
and is probably falsely attributed to
Ruysch.
Ruysch’s illustration (1703, vol. 3,
plate IV, Figure V, page 70; cf. Bhat-
nagar and Reid, 1996, p 224) of a “longitudinal dissection” (sagittal view,
Figure 1b) of a nasal septum of a human infant and his brief description
thereof are the only data related to
discovery of the human VNO. The
parts on the septum identified and labeled include the nasal septum, hairs
set in the nasal canals, one of the nasal canals, oblique sulci, and unrelated labels. The six oblique sulci have
no parallel to observations on young
or aged septa by other authors (e.g.,
Potiquet, 1891; Bhatnagar and Smith,
ARTICLE
THE ANATOMICAL RECORD (PART B: NEW ANAT.) 7
TABLE 2.
Arguments for and against the conclusion that Ruysch (1703, 1724) observed, described,
and illustrated the human vomeronasal organ (VNO)
Statement
For
Against
1. In the anterior and lower part of the
septum
2. Near the palate
Correct location in general
—
—
3. An opening or small mouth of some
sort of duct appears
VNO has a similar type of
communication
4. Concerning whose purpose or even
existence, I have read nothing by
other scholars
5. I believe that it serves to expel mucus
Correctly stated
VNO is positioned near above palate
(Bhatnagar and Smith, 2001)
The particular opening indicated
(Fig. 1b) appears too inferior and
close to the palate (see 1d)
—
2001). On the other hand, the nasal
canals have retrospectively been interpreted (erroneously in our opinion) as
the VNO. If Ruysch’s illustration is interpreted in a position 90 degrees rotated from Figure 1b, and drawn in
coronal section (Figure 1c), the position of these canals is inconsistent
with the VNO location. Based on our
data from fetal to adult stages (Smith
and Bhatnagar, 2000; Bhatnagar and
Smith, 2001), the “nasal canals” are
too close to the palate to represent the
VNO (compare Fig. 1b with Fig. 1c,d).
We must acknowledge the lack of an
available scale in Ruysch’s illustration
or, more definitively, histological series to verify our interpretation. But
there is indirect evidence supporting
our view.
The most comprehensive statement
by Ruysch relating to the “nasal canals” is as follows: “In the anterior
and lower part of the septum near the
palate, an opening or a small mouth of
some sort of duct appears, concerning
whose purpose or even existence, I
have read nothing by other scholars. I
believe it serves to expel mucous.”
(Plate IV, Figure 5, Letter E — translated from Latin). In our opinion, it is
the above statement that has given
rise to the notion that Ruysch is the
discoverer of the human VNO. Table 2
presents a word-by-word analysis providing arguments for and against a
relationship between the described
opening and the VNO opening as understood by recent work (see Bhatnagar and Smith, 2001, for further discussion).
We are now left with making interpretations. Strictly speaking, the de-
Accurately surmised
There are numerous other openings that
relate to mucus excretion.
scription by Ruysch was that of a septal mucosal pit, i.e., any externally
visible opening on the septum (Bhatnagar et al., 2002). This structure in
Figure 1b, pointed by a stylus (“D” —
“hairs, set in the nasal canal”), could
have corresponded to an opening for
any number of mucosal structures—
did it correspond to the true opening
of the VNO? Two important thoughts
lead to our following interpretation.
First, some investigators have shown
that the openings of the VNO are liable for misinterpretation, because
other structures can create a similar
aperture or surface depression (Bhatnagar et al., 2002; Jacob et al., 2000;
Smith et al., 2001b). Second, the VNO
is not synonymous with its surface
opening. In other words, it is a tube
found deep to the surface nasal septal
epithelium, which cannot be observed
grossly and, thus, must be viewed by
serial sectioning (Bhatnagar and
Smith, 2001; Bhatnagar et al., 2002).
Based on these thoughts, we conclude
as follows: (1a) The stylus in Ruysch’s
Figure 5 (Figure 1b,c) appears to
point to an opening in the septum as
he described. However, it could only
be the opening of the VNO and not the
submucosal organ itself. (1b) Although the human VNO is rather variable in superoinferior location (Bhatnagar and Smith, 2001; Smith et al.,
2001b), we believe the illustration indicates a position too close to the palate to indicate the true opening of the
VNO. (2a) Ruysch effectively encouraged Sömmering, Jacobson, Gratiolet,
and/or Dursy to explore the subject
further, and (2b) this culminated in
Kölliker’s (1877) definitive description
of a histologically identifiable, submucosal, elongated epithelial tube in the
nasal septum that comprises the human VNO. Kölliker (1877) thus described the actual organ itself, and not
a surface opening of uncertain relations, for the first time.
Sömmering’s Contributions
Samuel Thomas von Sömmering’s
(1755–1830) biographical note appears in the Dictionary of Scientific
Biography (Hintzsche, 1980b). In
1809, he (Figure 2a) published a
monograph on the human organ of
smell. Here, we rely on Pearlman
(1934) who presented an illustration
from Sömmering (Figure 2b). This
was a lateral view of the left side of the
nasal septum in an adult and had a
stylus entering an opening in the septal epithelium. The original text pertaining to this image remains unavailable to us, but the stylus was
purported (retrospectively by Pearlman) to enter the VNO. The position
of the opening is more in keeping with
published findings on surface openings that were histologically verified
to lead into the VNO (Johnson et al.,
1985; Bhatnagar and Smith, 2001).
The association of this opening in
Sömmering’s illustration with the
VNO cannot be verified with any certainty, and as noted above, a surface
opening does not correspond to the
organ itself. Thus, the portrayal of
Sömmering as the second to describe
the VNO (Pearlman, 1934) is inaccurate.
8 THE ANATOMICAL RECORD (PART B: NEW ANAT.)
Figure 2. a: Samuel Thomas von Sömmering (1755–1830). Copyright owner unknown. Courtesy of the National Library of Medicine, USA. b: The left lateral view of an adult human nasal
septum as published in Pearlman (1934, Figure 2) with the caption “view of adult human
septum. A probe is seen in Jacobson’s organ. This illustration is from Sömmering (1809) and
is the second time the organ was pictured.” The original illustration by Sömmering remains
unattainable by us.
Ludwig Levin Jacobson’s
Discoveries
In 1811, this now well-known monograph on the vomeronasal (Jacobson’s) organ of mammals appeared
under Francois Cuvier’s name, which
has been translated in its entirety by
Bhatnagar and Reid (1996). It is notable that there are no illustrations in
this work, and that most of it deals
with Steno’s (nasopalatine) duct of
mammals. The “Organ” as Jacobson
(Figure 3) called it, was said to “vanish
completely in man.” It is now clear
that Ludwig Jacobson did not play a
role in discovering the human VNO.
Two years later, in 1813, Jacobson
published a monograph in Danish,
under his own name, on the “Anatomical description of a New Organ in the
nose of the domesticated animals”
(with illustrations). This text has been
translated by Trotier and Døving
(1998). To our knowledge, it shows
the first coronal section of a VNO,
from a horse, in Figure VI, Plate IV of
this work. Jacobson, indeed, is the discoverer of the VNO in domesticated
mammals, but not of the human VNO.
Readers may obtain further historical
perspective from Bhatnagar and Reid
(1996) and Trotier and Døving (1998).
Other Relevant Contributions
Louis-Pierre Gratiolet (1815–1865, see
Coleman, 1980) wrote a thesis on the
VNO in animals. Even though he
mentioned Steno’s canal in humans, a
direct reference to the human VNO is
missing. There are four plates of illustrations, none of which pertained to
the human VNO. Gratiolet’s work has
historical value on the mammalian
VNO in general.
Emil Dursy (1828 –1878, see Mörike,
1984) published a two-volume work on
the human head. He examined several human embryos and recognized
“Jakobson’schen Organe” (sic) and its
cartilage. No illustrations accompanied
this description.
ARTICLE
without which the identity of the opening could not have been determined.
Kölliker emphatically adds “From now
on I will call (this structure) Jacobson’s
Organ” (the VNO). He also recognized
and named the bar-shaped cartilage below each VNO as Jacobson’s (paraseptal) cartilage. Kölliker also had examined newborns and children within 1
year of age. He mentions Ruysch as
having correctly described and illustrated the emptying point of this organ.
This statement by Kölliker was purely
retrospective, because even if Ruysch
has observed an opening, he did not
know the relationship to the VNO. A
VNO was observed in adults by Kölliker
for which he provided measurements;
by comparing this structure with that in
other mammals, he noted many of its
attributes missing in humans. He accepts his ignorance about the presence
of sensory epithelium. Some remarks
are made about the lack of a VNO in
birds. In closing, Kölliker mentions derivation in the human from animal-like
forms and that the human VNO is not
an atrophied organ.
This monograph was supported by
16 footnotes, two plates bearing 10
figures, and figure explanations. His
figures show complete consistency
with more recent works on the general
Kölliker as the Discoverer of
the Human VNO
Rudolf Albert von Kölliker (1817–1905;
Figure 4a) was professor of histology at
the University of Würtzburg, Germany.
A biographical note on him appears in
Encyclopedia Britannica (1990) and the
Dictionary of Scientific Biography
(Hintzsche, 1980a).
Kölliker was aware of Dursy’s (1869)
report on a blind sac in the human embryo, which emptied into the nasal cavity anteriorly, and which was interpreted by Dursy as the homolog of the
mammalian VNO. Kölliker studied fetuses 4 months and older and noticed a
round opening (what we know of today
as a septal mucosal pit, cf. Bhatnagar et
al., 2002). He showed the confluence of
this opening with the tubular VNO, histologically (Figure 4b,c). The use of histology was of paramount importance
Figure 3. Portrait of Ludwig Levin Jacobson
(1783–1843). Drawing rendered by Timothy
D. Smith from a print reproduced in Trotier
and Døving (1998). Reprinted by permission
of Oxford University Press.
ARTICLE
THE ANATOMICAL RECORD (PART B: NEW ANAT.) 9
Figure 4. a: Rudolf Albert von Kölliker (1817–1905). Reprinted by permission of the Bibliothek
Würzburg, Germany. b: Figures 6 and 7 from Kölliker (1877), showing the location of Jacobson’s organ in cross-section (top right; bottom) and its opening into the nasal cavity (top
left). c: Figure 2 from Kölliker (1877) showing the position of the vomeronasal organ relative
to other nasal cavity structures (compare with Figure 1c).
morphology and anatomical position
of prenatal (Kreutzer and Jafek, 1980;
Smith et al., 1997; Smith and Bhatnagar, 2000) and postnatal (Johnson et
al., 1985; Bhatnagar and Smith, 2001;
Smith et al., 2001b) human VNOs.
Some of his more specific microscopic observations, e.g., regarding
communicating mucous glands, also
were confirmed by later histochemical
investigations (Roslinski et al., 2000;
Bhatnagar and Smith, 2001). Considering Kölliker’s description complete
in every respect, attribution of the discovery of the human VNO to Kölliker
is well-deserved. His monograph,
translated into English, is presented
here as an appendix.
In conclusion, it is to be emphasized now that, when authors have attributed the “nasal canals” observed
by Ruysch as being the human VNO,
it has been a retrospective epiphany of
sorts. Little was known of the microscopic nature of the human VNO until
the second half of the 19th century,
when Dursy (1869) commented on
prenatal development and Kölliker
(1877) described histological structure of the VNO in fetuses and adults.
When histological observations such
as these were first provided, a discrepancy between studies became clear for
the first time—a discrepancy that continues to the present date. Studies that
used gross structural landmarks to locate the VNO reported that the VNO
may not be present in all adults (e.g.,
Potiquet, 1891). On the other hand,
histological studies reported a universal presence of the VNO in prenatal
and postnatal humans. When all data
are examined and reconstructed, Kölliker stands out as the discoverer of
the human VNO.
ACKNOWLEDGMENTS
We thank Dr. K. Lal Gauri, Professor
Emeritus, Dept. Geosciences, University of Louisville, for translating Kölliker’s work; Dr. Robert D. Luginbill
for translating page 26 from Ruysch
(1724); and Dr. Bert Ph Menco who
drew our attention to an article on
Rachel Ruysch, daughter of Frederick
Ruysch, in the magazine Kundschrift.
We also thank the research librarians
Felix Garza, Kathy Lynn Rogers,
Michel Atlas, and Jane Bottoms for
accessing the archival material for
this study. Dr. Robert D. Acland, Professor of Surgery, provided necessary
help in harvesting the nasal septum
examined in the study.
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Jacobson’s (1811) reports on the vomeronasal organ with comparative comments and English translations. Biomed
Res 7:219 –229.
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Wirbelthiere. Tubingen: Laupp (an oversize atlas, Vol. 2).
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Inc.
Gratiolet L-P. 1845. Recherches sur
l’organe de Jacobson. Thèse pour le Doctoral Médecine. Paris. 64 p ⫹ 4 plates.
Hintzsche E. 1980a. Kölliker, Rudolf Albert von. In: Dictionary of scientific biography. Vol. 7– 8. New York: Charles
Scribner’s Sons. p 437– 440.
Hintzsche E. 1980b. Sömmering, Samuel
Thomas. In: Dictionary of scientific biography. Vol. 11–12. New York: Charles
Scribner’s Sons. p 509 –511.
Ishimitsu K. 1958. Über die entwicklung
der drüsen des vomeronasalorgans beim
menschen. Yokohama Med Bull 9:148 –
156.
Jacob S, Zelano B, Gungor A, Abbott D,
Naclerio R, McClintock MK. 2000. Location and gross morphology of the nasopalatine duct in human adults. Arch Otolaryngol Head Neck Surg 126:741–748.
Jacobson L. 1811. Description anatomique
d’un organe observé dans le mammiferes, Ann Mus Nat d’Hist Nat, Paris (a
report by Cuvier on Jacobson’s memoir,
see English translation by Bhatnagar
and Reid, 1996). 18:412– 424.
Jacobson L. 1813. Anatomisk beskrivelse
over et nyt organ i huusdyrenes naese.
Veter Salesk Skrift 2:209 –246. (see English translation by Trotier and Døving,
1998)
Johnson A, Josephson R, Hawke M. 1985.
Clinical and histological evidence for the
presence of the vomeronasal (Jacobson’s) organ in adult humans. J Otolaryngol 14:71–79.
Kauer JS. 1969. A study of the structure
and function of the vomeronasal (Jacobson’s) organ, including investigations
into its ultrastructure in mammals. Unpublished Master’s Thesis, Clark University (cited by Wysocki, 1979).
Kölliker A. 1877. Über die Jacobson’schen
organe des menschen. Leipzig: Wilhelm
Engelmann. 11 p ⫹ 2 plates with explanation of figures.
Kreutzer EW, Jafek BW. 1980. The vomeronasal organ of Jacobson in the human
embryo and fetus. Otolaryngol Head
Neck Surg 88:119 –123.
Lindeboom GA. 1980. Ruysch, Frederick.
In: Dictionary of scientific biography.
Vol. 11–12. New York: Charles Scribner’s
Sons. p 39 – 42.
Löwensteyn M. 2000. De wondere wereld
van Rachel Ruysch. Kunstschrift 1:16 –
23.
Meisami E, Bhatnagar KP. 1998. Structure
and diversity in mammalian accessory
olfactory bulb. Microsc Res Tech
43:476 – 499.
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Monti-Bloch L, Jennings-White C, Berliner
DL. 1998. The human vomeronasal system. Ann N Y Acad Sci 855:373–389.
Mörike von Klaus D. 1984. Hundertfünfzig
Jahre Anatomie auf dem Österbrg. www.anatomie.uni-tuebingen.de/history/
ana150.html. 7 p.
Ortmann R. 1989. Über sinneszellen am
fetalen vomeronasalen organ des menschen. HNO 37:191–197.
Pearlman SJ. 1934. Jacobson’s organ (organon vomero-nasale, Jacobsoni): its
anatomy, gross, microscopic and comparative, with some observations as well
on its function. Ann Otol Rhinol Laryngol 43:739 –768.
Potiquet M. 1891. Du canal de Jacobson.
De la possibilité de le reconnaitre sur le
vivant et de son rôle probable dans la
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12:737–753.
Rathke H. 1838. Entwicklungsgeschichte
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Roslinski DL, Bhatnagar KP, Burrows AM,
Smith TD. 2000. Comparative morphology and histochemistry of glands associ-
ARTICLE
ated with the vomeronasal organ in humans, mouse lemurs, and voles. Anat
Rec 260:92–101.
Ruysch F. 1703. Thesaurus Anatomicus Tertius. Amstelaedami: Joannen Wolters. p
48 – 49, 70; Plate IV. Fig. 5. (see English
translation by Bhatnagar and Reid, 1996).
Ruysch F. 1724. Thesaurus Anatomicus.
Vol. III. Amsterdam: Waesberg J. p 26.
Smith TD, Bhatnagar KP. 2000. The human vomeronasal organ. II. Prenatal development. J Anat 197:421– 436.
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Prenatal growth of the human vomeronasal organ. Anat Rec 248:447– 455.
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Anatomical position of the vomeronasal
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Takami S. 2002 Recent progress in the
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Trotier D, Døving KB. 1998. ‘Anatomical
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Trotier D, Eloit C, Wassef M, Talman G,
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341.
APPENDIX
UEBER
DIE JACOBSON’SCHEN ORGANE DES MENSCHEN
VON
A. KOLLIKER
MIT 2 TAFELN
ABOUT
THE JACOBSON’S ORGAN OF HUMAN BEINGS
BY
A. KOELLIKER
IN F. VON RINECKER, FETSCHRIFT. LEIPZIG:
WILHELM ENGELMANN. PP. 3- 11 ⴙ EXPLANATION OF FIGURES ⴙ 2 PLATES.
BY A. KOLLIKER 1877
In 1869, Dursy1 reported in human embryos from 8-20 ‘ctm’ long, a small blind sac emptying in the nasal cavity
in the lower frontal end of the nasal septum, and interpreted this as homologue of Jacobson’s organ in mammals.
Strikingly, this concise definition of the structure did not find any further notice, at least no mention of it has been
found in recent anatomical or embryological journals, and yet its occurrence is fully confirmed and can be
demonstrated easily in every human embryo. Furthermore, it is found in the postembryonic period in children as
well as in the adult. Without doubt these organs are equivalent to the mammalian Jacobson’s tubes
(Jacobson’schen Rohren) and from now on it will not appear that they will be an insignificant addition, though
rudimentary structures in humans.
I have looked at the human embryos older than four months and have found almost the same conditions in all
of them. On the lower frontal portion of the nasal septum, somewhat before where the Stenson’s passages empty
in the nose, and in a frontal plane passing through the incisors, one finds on both sides a small rounded opening
which can be recognized with the naked eye in embryos older than six months, and at least with a hand lens in
younger embryos. Vertical sections in this vicinity of the septum (Figs. 2 to 7) teach us that this opening leads into
a cylindrical or laterally compressed canal, which runs approximately parallel with the floor of the nasal cavity, in
which the mucous membrane that drapes the cartilaginous septum slightly extends backwards and then blindly
ARTICLE
THE ANATOMICAL RECORD (PART B: NEW ANAT.) 11
12 THE ANATOMICAL RECORD (PART B: NEW ANAT.)
ARTICLE
ends. This canal is draped with the same epithelium which also covers the mucous skin of the septum; in one case
of a six-month-old embryo I have observed well- preserved hair on this epithelium. In addition, in embryos older
than six months this canal has a sometimes more and sometimes less defined wall of connective tissue that clearly
shows that individual glandular passages develop from the epithelial covering of the canal, as they are found in
large numbers in the rest of the septal mucosa. The cross-section of the epithelial tubes of this canal is 0.16 to 0.32
mm in younger embryos, whereby it is to be noted that the canal at its opening is completely round, but in the
remaining course it appears flattened. In older embryos the canal is throughout higher than wide, and in one case
of a six-month-old embryo was 0.42 mm high and 0.22 mm wide not counting the connective tissue cover. Its
lumen was 0.29 mm high and 0.086 mm wide with the epithelium 54 to 59 microns thick. The length of the canal
I have not yet determined exactly and can thus far only give approximations from the number of sections in which
I have seen it, its length not exceeding 1 mm.
I observe further that the connective tissue wrapping the canal is not developed clearly in all embryos. Where it
is found, it generally appears in the contour of the epithelial canal, only that it is more stretched in height as in
Figure 7.
From the position of the described organ, which from now on I will call Jacobson’s organ, is to notice that it lies
without exception in the neighborhood of the thinnest part of the cartilaginous septum. Conversely, the underlying
marginal portion of the septum is the thickest which without exception builds a long bulge over the floor of the
nasal cavity following which one can trace the Jacobson’s organ.
On the lower edge of the nasal septum of the embryos lie, at the position of the Jacobson’s organ, two flat
cartilaginous strips (Figs. 3,4), which were observed by Jacobson2 and later by Huschke3 who called these as
‘Pflugschaarknorpel’ (ploughshare cartilage) are equivalent to the cartilage in adults also mentioned by Dursy.
Because these cartilages, which by the way exceed the Jacobson’s organ in length on both sides and project as
spikes (Figs. 2,5), are doubtless the homologue of the cartilage which enclose the Jacobson’s organ in mammals.
So I name them Jacobson’s cartilage and note further that these structures are seated on its lateral sides as soon
as the vomer becomes distinct, thus these in my experience are also seen, albeit atrophied, in adults.
After I had found the Jacobson’s organ in embryos of different ages, it was easier for me to search for these in
postembryonic stages; yet I had only newborns and children within one year of age available to me at that time.
The only person who had seen this structure was RUYSCH, as cited by J. Fr. Meckel and E. H. Weber, who had correctly
described and illustrated 4 in his “Thesaurus anatomicus” the emptying of the organ by introducing a probe (italics are
ours). At the corresponding site where the organ is found in older embryos I have also found the organ without
exception in the newborns (Figure 1) and children one year in age, which I had till then studied, allowing to affirm
that at this age it is a normal occurrence. In support, I provide the following measurements in a newborn of few
days with the long diameter of the head 16.3 cm and whose nasal septum was 1.65 cm high and 3.3 cm long (Figure
1), in an eight-month-old embryo with head length 8.5 cm, septum 2.2 cm high, and in an embryo of six months
(septum 2 cm long and 1 cm high) on the side position.
Distance of the Jacobson’s organ from surface of the nasal cavity
Width of the opening of Jacobson’s organ
Distance of the same from Stenson’s passage
Distance of the same from frontal nasal cavity
Distance of the same from upper edge of the septum
Embryo
6 months
1.5
0.5
?2.5
5.0
8.7
Embryo
8 months
3.0
0.7
5.0
8.0
9.0
Child of
few days
2.5
0.33
9.5
14.2
The Jacobson’s organ occurs not only among children, but is also found in adults and is not different from that
mentioned in short and partly in incomprehensible words by Meckel (J. Fr.)5 and illustrated by Sommering6 as the
mucous membrane passage (Schleimhautgang) on nasal septum. I find this passage, that undoubtedly represents
a further development of the Jacobson’s organ of a child, in a large majority of cases that I have observed since I
became aware of this organ (Figure 8), and stand by to characterize this as an organ of greater perpetual
occurrence than Stenson’s passage, even though it is easily possible that in the few cases in which I missed this on
one or both sides it was due to sickness that the mucous was wasted. My knowledge of the fine architecture of the
Jacobson’s organ in the grown ups is based on relationships due to scarcity of well-preserved specimens for study
and I can only say that this passage does not mostly proceed backwards but is also at the same time somewhat
pulled upwards, exceptionally it even runs steeply upwards, so that its situation is exactly the same as that in the
embryos and in the children. Understandably, in adults the swelling that embraces the lower thick margin of the
septal cartilage is much better developed and one does not always easily find the opening of the organ when one
is directed toward this swelling and the Stenonian duct.
In 18 cases the measurements in adults are as follows:
Distance of the Jacobson’s organ from surface of the nasal cavity
Distance of the same from the Stenonian duct
Distance of the same from the angle between the septum and the upper lip
Width at the opening of the organ
Length of the canal
6.0–13.0 mm, in the middle 8.5 mm
1.0–8.0 mm, in the middle 5.0 mm
21.0–29.0, in the middle 24.0 mm
1.0–1.6 mm, in the middle 1.1 mm
2.0–7.0 in the middle 3.6 mm
ARTICLE
THE ANATOMICAL RECORD (PART B: NEW ANAT.) 13
That the Jacobson’s cartilage occurs—whether perpetual is subject to further investigation— on both sides in
adults in my experience on 1-3, was already mentioned and I further point out that recent studies, with the
exception of Dursey, do not appear to recognize it. Taking this opportunity I present a condition, to my knowledge
not yet reported, of the cartilaginous septum. The same always develops from its lower posterior edge as a 4 – 6 mm
wide cartilage plate, which, more or less is completely enclosed and covered by the upper edge of vomer plate, pulls
backwards and upwards along the lower edge of lamina perpendicularis of the Siebbein (?some bone) and nearly
reaches the rostrum sphenoidale, yet fuses with the same (Figure 9). This “ processus sphenoidalis septi cartilaginei” as I call it, had possibly been seen by Schwegel7 , but his writing was so vague that this cannot be said with
certainty.
I have also made observations on the oft mentioned Stenson’s passage or the ductus nasopalatinae. I find the
nasal junction of this passage open in most cases, but there are enough examples in which this is completely closed
or disappears totally without any trace. Concerning its junction with the gum among adults, so far I have not seen
any case in which the same condition existed, whereas it can be seen among children from the first year. Definite
information however can be obtained by carefully preparing serial sections which I have been able to prepare only
one of adults in which it showed that passage at the gums was closed. In this case the passage had, where there was
a distinct clearing, a 53 ␮m thick flicker (flimmer) epithelium with cylindrical cells and so many grape-shaped
mucous glands joining it, that they had completely overtaken the surrounding connective tissue. Near the nasal
opening to about 1.28 mm long passage and the surrounding connective tissue (corresponding to the width of the
bony canal), 5.13 mm, the structure, not considering the glands, looked almost cavernous due to the presence of
numerous veins. Soon, the passage became narrower to 0.5 mm, then descending 0.22 mm it disappeared (Figure
10).
This is essentially what I have to convey about the Jacobson’s organ among human beings. Now I wish to state
concisely why I, like Dursy, place the organ in question without fail on the side of the Jacobson’s organ of
mammals, although many attributes of the last have not been observed in human beings, such as a cartilaginous
capsule, the access from olfactory cilia, the opening into the Stenson’s passage; the specific epithelium (S. C.
Balogh in Wiener Sitzungesberichte, 1860) and the supply of nasopalatine region with fibers.
What first concerns the relationship to Stenson’s passages or ductus nasopalatinus, so these are not original,
because in very young mammalian embryos with still unformed palates, they merge freely into the Jacobson’s
organ simply on the frontal lower portion of the nasal septum. Thus among humans as well this primitive condition
could exist, and it appears quite understandable that in him the Jacobson’s organ from the beginning on has a
higher position on the septum compared to that in animals, so they could not at all come in the area of the
Stenson’s passage.
From this higher position, it can be further explained why in humans the Jacobson’s cartilage typically has a
constant position on the lower septum. One could then argue that these cartilages extend much farther than the
Jacobson’s organ in mammals, and are not part of the floor of the nasal cavity. Such is truly the case with the
Jacobson’s organ.
With reference to the developed opinions in the last two paragraphs I further observe, that in human beings in
certain cases the Jacobson’s organ lies very close to the concerned cartilage.
Further, whether or not the Jacobson’s organ of humans contains nerve fibers and possess sensory epithelium
(sinnesepithel), is not known and therefore these points do not enter into this discussion. Because the olfactory
fibers on the septum reach furthest to the area of Jacobson’s organ, as also given by SCARPA, it does not seem
implausible that these organs among humans by their specific construction offer indications of kinship to the
mammalian organ. Even if it were not so, I would not find any hindrance to the above explanations that the organ
of the mammalian embryos in the beginning also do not show any specific epithelium.8
This is not the place to discuss in detail the Jacobson’s organ among animals, therefore, I observe the following.
First of all, much is yet to be learned about the extension and structure of this organ. With respect to mammals,
I point to the hardly known knowledge in Germany of Gratiolet’s9 work, and observe that after my studies on oxen,
the cartilage of the organ and the inner epithelium are not thoroughly described, about which I will reserve my
further comments. Among lower vertebrates the reptiles seem to have the Jacobson’s organ (Rathke10), Stannius11,
von Leydig12, and perhaps also the amphibians (Gotte13, Born14) and the fishes (Winther15). However, except that
of v. Leydig, precise statements are yet not available on any of these classes.
Among birds Jacobson’s organ is so far not known and my efforts on this have been fruitless. Nevertheless, it is
striking that the exit passage of the nasal gland partly extends in a fashion as in humans. Because this passage in
my knowledge has not been accurately described by any one16, so I give for other’s benefit a short description of
its course in geese. From the upper edge of the eye cavity begins the passage of the nasal gland, under the frontal
anterius and runs in a depression between these bones and the nasal bone at the upper surface of the ligamentous
side portion of the nose. Somewhat behind the bony nasal cavity the passage perforates the ligament wall and runs
on its underside, i.e., on the lateral wall, downwards towards the floor of the nasal cavity, where it enters the
connecting fold, which the fore-chamber of shell (GEGENBAUR) meets with the septum, whereby it is endowed
14 THE ANATOMICAL RECORD (PART B: NEW ANAT.)
ARTICLE
with a concave cavity directed towards the front. So, the passage reaches the septum and runs in it right and left
of septal cartilage towards front, finally ending at a site, sharply defined in goose, with a small ending which is
difficult to recognize. This point is found there, where the lateral margin of a fractured plate that makes the middle
portion of the frontal section of the floor of the nasal cavity joins the septum. In a grown goose, the passage is
nearly 4 –5 mm in the septum and its ending is 5 mm from the frontal edge of the septum (at the site where both
frontal pouches of the nasal cavity come together). On frontal sections across the septum lies the over 1 mm wide
passage beneath a thickening of septal cartilage and above the strong nervi nasopalatini. However, I would not have
described this situation in such a detail had this wide passage not reminded me of the human Jacobson’s organ by
its position on the septum; perhaps, that portion of the organ lying in the septum is homologous with Jacobson’s
organ. In the latter case, additional consideration is deserved, due to the fact that another small blind sac begins
where this passage turns laterally, so that one may interpret it as the Jacobson’s organ, into which the nasal gland
empties posteriorly. I note further, that at the junction of the passage, which I have also seen in hen and Buteo
vulgaris, a pavement (flat) epithelium as seen in nasal frontal cavities, that in a young goose bears brown pigment
granules, is found instead of the cylindrical epithelium that occurs inside.
Secondly I allow myself some remarks regarding the function of Jacobson’s organ in mammals. When one
considers the short width of this organ and the narrowness of the passages through the Stenson’s canal, which are
additionally closed near the mouth cavity in certain animals (in horse after Cuvier, in Cavia and in camel after
Gratiolet), when one further thinks that the organ in question is enveloped by a rigid capsule and closed behind,
then one is led to believe that it would be impossible to have the purpose to take air and olfactory materials from
oral cavity through Stenson’s passage and thereby to distinguish harmful from harmless food products (Cuvier). So
it remains, when one does not want to accept that Jacobson’s ducts are simply secretory organs-for which the
indications come above all from their profusion of blood, their innumerable glands, and their richness on branches
of nasopalatinus nerve, against which however speak the availability of innumerable olfactory fila and its sensory
epithelium-nothing else can be assumed that they differentiate juices and substances from each other, which work
on their specific nerves and so enable the organisms to somewhat directly obtain knowledge of chemical composition of their own secretions. Under this assumption the flicker (flimmerung) in the organ, which in my
observations on calf produces current going from inside to outside, becomes understandable. Whether the organ
is also secondarily to supply secretions which moistens the nasal cavity (Jacobson) or the snout, which can
facilitate the intake of food or works on the nerves of tongue is possible. However, I do not want to close doors on
these considerations and above all point out that possible physiological experiments could settle it on one or the
other side.
In conclusion, I stress once again that through the Jacobson’s organ in humans the number of rudimentary,
perhaps totally non-functional organs, will not just be increased by an insignificant feature. Undoubtedly this organ
is inherited from an earlier, animal-related form, and appeared in humans in a way, which shows that this unlike
the Meckel’s cartilage, the Muller’s passage in human form among others as atrophied, rather be considered only
as an undeveloped embryonic feature, like the breast gland in man.
EXPLANATION OF FIGURES
ON PLATES I AND II
(Editor’s Note: The plates have been reproduced at about 50% of their original size.)
Fig. 1. Nasal dividing wall of a few days-old child with the opening of the Jacobson’s organ. Natural size.
Fig. 2. Frontal section through the frontal portion nasal cavity, the gums and the sacks of the inner incisor of
human embryo of 4 months. The Jacobson’s organ sits deeper than normal and shows one of its junctions. The
Jacobson’s cartilage appears on both sides closer to the septum in the form of three small bars, which are not
continuation of each cartilage, as shown in Figs. 3 and 4. x 8.
Fig. 3. A similar section located somewhat posteriorly in another human embryo of 4 months. The Jacobson’s
organs lie higher, the Jacobson’s cartilage are simple. The position of the inferior concha (Muschel) is clear as of
both upper molars. x 8.
Fig. 4. A similar frontal section of a human embryo of 5 months. One sees the transverse sections of the
Jacobson’s organ, the Jacobson’s cartilage, the position of 4 incisors, the upper molar, the inferior concha and
centered within the gum a round epithelial mass, the overly grown mass formed by the growth of gum partition
by the epithelium in the gum node of a primitive mouth cavity. x 8.
Fig. 5. Nasal septum of human embryo of 6 months. one Jacobson’s organ with opening, the other met obliquely.
Jacobson’s cartilage of both sides represented by 3 small ligaments.
Fig. 6. Jacobson’s organ of embryo of Fig. 3 with the joining portion of nasal septum in high magnification. The
opening is seen in one organ.
Fig. 7. The same organ towards its posterior end, here with clear connective tissue encapsulation.
Fig. 8. Nasal partitioning wall of an adult with the opening of Jacobson’s organ. Natural size.
ARTICLE
THE ANATOMICAL RECORD (PART B: NEW ANAT.) 15
Fig. 9. Cartilaginous and bony nasal septum of a grown up in natural size. a. cartilaginous septal sphenoidal
process, exposed by removal of the lamella of upper frontal edge of the vomer bone. b. Jacobson’s cartilage
(Pflugschaarknorpel, Huschke)
Fig. 10. Soft portion of an adult Canalis incisivus, approximately 19 times enlarged. a. Stenson’s passage with
three joining glandular passages. b. artery. c. vein. d. nasopalatinus Scarpae. e. secretory glands.
FOOTNOTES
1. On the evolutionary history of the human head and of higher vertebrates. Tubingen 1869 with atlas. p.
135–139, Table VII, Fig. 6 c, Fig. 7; Table VIII, Fig. 2 c; Table IX, Fig. 6 c.
2. Annales du Museum d’histoire naturelle. Vol. XVIII. 1811. Cuvier’s report on Jacobson’s memoir. p. 421.
3. Lessons from the viscera and sensory organs in Sommering’s Anatomie. p. 606.
4. Thesaurus Anatomicus III. Amstelod. 1703. p. 49. “ It appears in the anterior and inferior parts of the septum
just above the palate, appearing literally along with its duct. I have read nothing from authors concerning Its use
and its existence. I think it serves for mucus secretion. See Plate IV, Fig. 5, Thesaurus 3, Letter E. ” (Authors’ note:
see Bhatnagar and Reid, 1996, p. 223).
5. In Handb. Der Menschel. Anat. Bd. IV. 1820. p. 141. “ On the lower edge of septal wall, a passage often runs
posterior to front a narrow, blind on the back, which opens not too far behind the frontal edge; evidently about the
Jacobson’s organ (Sic. ?) in this regard Ruysch and Jacobson l.s.c. are cited and should have been named ”
remainder of the Jacobson’s organ.“
6. The illustration of the human organ of smell, Frankfurt 1809, Table II, Fig. 1, 9. “ Opening of the perpetual
mucous membrane canal, in which a probe has been introduced. Such a probe can be easily introduced in the canal
for several unit length.”
7. Zeitschr. f. rat. Medicin. 3. R. Bd. V. 1859. p. 309.
8. In a sheep embryo of 2.7 cm I found in Jacobson’s organ cylindrical epithelium; contrary to this, in one embryo
of 11 cm, already a differentiated epithelium on both sides is found in which the medial side was three or four times
thicker as the lateral sides.
9. Recherches sur l’organe de JACOBSON. Paris, Rignoux, 1845. Thesis.
10. Developmental history of the viper. That Rathke describes as nasal gland is not different from Jacobson’s
organ.
11. Compare Anatomy of Vertebrates. 2nd edition, 1854. p. 175.
12. About the knowledge of sensory organ of snakes in M. Schultze’s Archives. Vol. VIII, 1872. p. 318 –329. Plate
XV.
13. Development of fire-bellied toad. p. 654.
14. About the nasal cavities and tear passage in amphibians in Gagenbauer’s Morph. Jaharbuch, Vol 2, p. 577.
Whether those written by Goette and Born as side sacs of nasal cavity be considered as Jacobson’s organ, is not yet
proved. Born is against such explanation, because the organs in question open only in the nasal cavity and not also
in the mouth cavity (p. 604. Anm.). Because same conditions are present in Jacobson’s organ of humans and few
mammals (see below), so is this reason not adequate.
15. Fiskenes Ansigt, Forste Afsnit in Naturh. Tidsskrift. 3. R. X. vol. P. 185. Pl. I, Fig. 16, 18; Plate II, Figs. 1, 3,
5. Those parts indicated in young salmon by Winther are, less deep, front at snout at the outside between both nasal
cavities, these depressions are not Jacobson’s organ. If this explanation is correct, so it can be said, that the
Jacobson’s organ existed originally independently of nasal depressions, that also Dursy had in some sense tried to
defend in the case of embryos of higher orders. (l.c.s. p. 132, u. Fig.).
16. Jacobson (Sur une glande conflomeree appartenant a la cavite nasale in Nouveau Bulletin des sciences de la
societe philomatique de Paris. T. III. VI. Annee. 1813. page 267) says, the gland joins at the frontal portion of the
nasal cavity at the end of lower turbinate (Muschel). Also Nitsch had the site of nasal opening, that he found only
in geese and in the Charadrius oedicnemus, not accurately described) (Meck. Archiv. VI. p. 234) and observes only
“ this ends in the nose apparently quite in front” (p. 248) and in Charadrius “ the opening is found on the inner side
of the outer nasal wall.”
TRANSLATOR’S COMMENTS
No attempt was made for a literary translation; instead it is mainly kept literal to maintain Kolliker’s ideas
as expressed in the German text. Throughout the memoir, each page had its footnotes; in the translation,
all 16 footnotes have been consecutively numbered and brought together.
K. Lal Gauri, Professor-Emeritus, University of Louisville
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discovery, vomeronasal, jacobson, 1877, lliker, interpretation, human, organy, English, translation, ruysch
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