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Environmental and Molecular Mutagenesis 00:00^00 (2017)
Letter to the Editor
Comments on “Sesamol Ameliorates Radiation Induced
DNA Damage in Hematopoietic System of Whole Body
c-Irradiated Mice”
S. M. J. Mortazavi
*
Diagnostic Imaging Center, Fox Chase Cancer Center, Philadelphia,
Pennsylvania 19111
This letter is regarding the concerns about the article
entitled “Sesamol ameliorates radiation induced DNA
damage in hematopoietic system of whole body girradiated mice” by Kumar et al. published in the Environ
Mol Mutagen [Kumar et al., 2017]. Despite its strengths,
the paper authored by Kumar et al. has at least one major
and some minor shortcomings. A major shortcoming of
this paper comes from ignoring this cardinal point that
without knowing the optimum dose of different radioprotectors, comparison of their effects at specific doses is
nonsense. For example, the authors have compared the
radioprotective effect of sesamol (20 mg/kg) with that of
amifostin (20 mg/kg). It is worth noting that the amifostin
doses used by other researchers is much higher [167 [Liu
et al., 2015], 200 [Akbulut et al., 2014; Liu et al., 2015;
Yurut-Caloglu et al., 2015; Aktoz et al., 2016; Cakir
et al., 2016; Demirel et al., 2016], and 400 mg/kg [Oshima et al., 2015] of WR-2721, i.p.) which clearly shows
that the optimum dose of this radioprotective agent is
much higher than the dose used by Kumar et al. Interestingly, the authors have not even performed any experiment to determine the optimum dose of Sesamol and the
rationale for using the dose of 20 mg/kg is not clear.
Another shortcoming of this paper is due to overfocusing on traditional Walter Reed (WR) radioprotectors
and ignoring the key role of radiation mitigators in a
wide range of applications from nuclear accidents to
space missions. Recent studies show the significant radioprotective effect of vitamin C and introduces this antioxidant agent as a non-toxic, cost-effective, easily available
radioprotector in life-threatening exposure to lethal doses
of ionizing radiation [Mortazavi et al., 2015b]. Furthermore, vitamin C can be used at intervals longer than 24 h
after exposure [Mortazavi et al., 2014, 2015a]. It is worth
mentioning that Kumar et al. again without knowing the
optimum dose of vitamin C or melatonin have compared
their radioprotective effects with that of Sesamol “Strong
C 2017 Wiley Periodicals, Inc.
V
antioxidant activity of sesamol has been reported in comparison to standard antioxidants like vitamin C, curcumin, melatonin, etc. [Mishra et al., 2012]; additionally, in
V79 cells it has shown higher radioprotection as compared to melatonin [Mishra et al., 2011]”.
Another shortcoming of this paper is due to using soybean oil for preparing Sesamol while amifostine was prepared in distilled water “Sesamol was dissolved in 2% (v/
v) DMSO, and final volume was made up with soybean
oil to obtain dose of 20 mg/kg bd wt (200 mL) for each
animal. While same dose of amifostine was prepared in
distilled water. Mice were administered (i.p.) sesamol and
amifostine in their respective groups.”. In this light, it can
be hypothesized that at least some of the observed radioprotective effects of Sesamol could be due to soybean oil.
CONFLICT OF INTEREST
None declared by the authors
REFERENCES
Akbulut S, Sevmis S, Karakayali H, Bayraktar N, Unlukaplan M, Oksuz
E, Dagdeviren A. 2014. Amifostine enhances the antioxidant and
hepatoprotective effects of UW and HTK preservation solutions.
World J Gastroenterol 20:12292–12300.
Aktoz T, Caloglu M, Yurut-Caloglu V, Yalcin O, Aydogdu N, Nurlu D,
Arda E, Inci O. 2016. Histopathological and biochemical
*Correspondence to S. M. J. Mortazavi, Ph.D, Professor of Medical
Physics, Visiting Scientist at Fox Chase Cancer Center, Doss Lab R432, 333 Cottman Avenue, Philadelphia, PA 19111. E-mail: S.M.Javad.
Mortazavi@fccc.edu
Received 9 August 2017; provisionally accepted 11 September 2017;
and in final form 00 Month 2017
DOI 10.1002/em.22143
Published online 00 Month 2017 in
Wiley Online Library (wileyonlinelibrary.com).
Environmental and Molecular Mutagenesis. DOI 10.1002/em
2
Mortazavi
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