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j.hlc.2017.06.463

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Abstracts
S244
461
Alterations in Echocardiographic Right
Ventricular Size and Function Parameters
with Pulmonary Embolism
S. Trivedi 1,∗ , A. Terluk 2 , E. Chia 3 ,
C. Mussap 2 , V. Chow 4 , L. Kritharides 4 ,
A. Ng 4 , L. Thomas 1
1 Westmead
Hospital, Sydney, Australia
2 Liverpool Hospital, Sydney, Australia
3 St George Hospital, Sydney, Australia
4 Concord Hospital, Sydney, Australia
Background: Performing a transthoracic echocardiogram
(TTE) is recommended in pulmonary embolism (PE); established TTE features of PE include right ventricular (RV)
dilation and systolic dysfunction. We sought to determine the
most sensitive TTE parameter associated with confirmed PE.
Methods: 239 consecutive patients with confirmed PE
by computed-tomography pulmonary angiography (CTPA)
and/or lung ventilation/perfusion scintigraphy (VQ scan)
from 2 tertiary centres, (Liverpool Hospital, n = 74; Concord
Hospital, n = 165), from 2001-2010 with adequate TTE images
performed during admission were analysed. Demographics and clinical events were collected from hospital medical
records. TTE measurements were performed by 4 investigators blinded to patients’ details. The PE cohort was compared
with a group of healthy controls (n = 74).
Results: Of 239 patients (mean age 65.8 years, 57% female),
70 (29%) had DVT, 30 (13%) had diabetes and 26 (11%) malignancy. RV volumes were increased in the PE cohort (RV
end-diastolic volume, 55.7 vs 31.5 mL, p < 0.0001). Parameters
of RV function including fractional area change (FAC) (30.5%
vs 41.2%, p = 0.02) and RV ejection fraction (EF) were reduced
as was the pulmonary VTI (12.7 cm vs 15.6 cm, p < 0.0001)).
Left ventricular EF was similar between the groups. Receiveroperating-characteristic (ROC) curve analysis demonstrated
that RV end-diastolic and end-systolic volumes had the highest area-under-curve (AUC: 0.86 and 0.87 respectively) and
ratio of pulmonary valve to infundibulum an AUC of 0.78. RV
functional parameters were not as powerful determinants.
Conclusions: Our PE cohort demonstrates numerous significant RV structural abnormalities that may be incorporated
into diagnostic algorithms.
http://dx.doi.org/10.1016/j.hlc.2017.06.462
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462
An Update on Soldier’s Heart: Complete
Results from the 2015-16 ‘NSW Healthy
Military Recruits Cardiometabolism
(NHMRC)’ Study
K. Stanton 1,∗ , L. Wylie 1 , D. Celermajer 2,3
1 Heart
Research Institute, Sydney, Australia
University of Sydney, Sydney, Australia
3 Cardiology Department, Royal Prince Alfred
Hospital, Sydney, Australia
2 The
Background: In 2016, we reported preliminary results on
53 Army recruits and the effect of exercise on their anthropometry and echocardiography. We now report on the entire
study experience.
Purpose: To investigate the effects of a combined endurance
and strength program on cardiac remodelling, in Army
recruits.
Methods: 115 male recruits (21+/-3 yrs old) were studied before (Phase 1) and after (Phase 2) an 80-day exercise
program. A subset of 63 completed a further 72-day higherintensity program (Phase 3).
Results: Fitness significantly improved after moderateintensity (estimated VO2 max 44.9 to 50.3 ml/kg/min,
p < 0.01) and high intensity training (VO2 max 51.1 l/kg/min,
p < 0.01). BMI (p < 0.01) and body-fat percentage (p < 0.01)
decreased significantly.
Phase 2
Phase 2
Phase 3
...........................................
15.6 ± 4.0
12.5 ± 2.6
12.8 ± 2.3
Left Ventricular End
Diastolic Volume (ml)
* ++
127 ± 23
139 ± 20
153 ± 24
Left Ventricular Mass
(g) * ++
149 ± 27
157 ± 30
167 ± 26
Left Ventricular Stroke
Volume (ml) *
83 ± 16
90 ± 20
91 ± 16
Right Ventricular End
Diastolic Area * ++
21 ± 4
24 ± 3
26 ± 4
Right Ventricular base
(mm) * ++
37 ± 4
39 ± 4
44 ± 5
Body fat (%) * ++
* Phase 1 vs Phase 2 p≤0.01, ++ Phase 2 vs Phase 3 p≤0.01
Conclusion: Soldier’s Heart is characterised by increased
cardiac chamber size, LV mass and improved biventricular
function in response to increasing training intensity.
http://dx.doi.org/10.1016/j.hlc.2017.06.463
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