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j.jval.2017.08.1717

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VA L U E I N H E A LT H
Objectives: It aims to examine two proxy versions of EQ-5D-5L in Japanese for
their reliability and validity.? Methods: We compared various patient groups with
use of EQ-5D-5L in Japanese version (Self-response version) and two proxy versions.
In Proxy 1, a proxy will be asked how he/she would make an evaluation when evaluating a health condition for a subject. In Proxy 2, a proxy will be asked how it should
be determined when a subject can communicate his/her own health condition.
Proxy version evaluated an occupational therapist in charge. For the statistical processing, reliability and validity were calculated with Cronbach?s ?? coefficient and
Pearson?s correlation coefficient respectively through using STATA14.0.? Results:
Total 251 patients became the subjects. The breakdown of disorders was 101 patients
for cardiac disorder, 75 patients for respiratory disorder, 41 patients for cerebral
tumor, and 34 patients for cervical myelopathy. 159 patients were female (63.3%).
The mean scores of EQ-5D-5L were 0.739 (95%CI; 0.718-0.764) for Self-response,
0.735 (95%CI; 0.710-0.759) for Proxy 1, and 0.729 (95%CI; 0.705-0.754) for Proxy 2.
?? coefficient indicated 0.929 for Self-response/Proxy 1 and 0.956 for Self-response/
Proxy 2. When verifying ?? coefficient with 3 scores by disorder, cardiac disorder
(0.951), respiratory disorder (0.985), and cerebral tumor (0.912) indicated higher
while cervical myelopathy (0.777) indicated lower. The correlation coefficient was
0.867 for Self-response/Proxy 1 and 0.952 for Self-response/Proxy 2.? Conclusions:
We successfully clarified the reliability and validity for two proxy versions of
EQ-5D-5L in Japanese. It was concerned that Proxy 2 may possibly estimate a
patient?s QOL to be lower and the reliability would become less depending on
disorder. Thus, it is required to give careful attention to those results when using
Proxy versions.
PHP180
Allowing Respondents To Skip Items During Electronic Collection
Of Patient-Reported Outcome (PRO) Data: Does It Matter?
O?Donohoe P1, Eremenco S2, Coons SJ2, Crescioni M2, Arnera V3
Health, London, UK, 2Critical Path Institute, Tucson, AZ, USA, 3ERT-Geneva, Geneva,
Switzerland
1CRF
Objectives: The collection of electronic patient-reported outcome (ePRO) data
in clinical trials presents an opportunity to minimize missing data by requiring
subjects to respond to all items in order to complete the questionnaire. However,
implementation of this data entry rule can have unintended consequences. The
purpose of this report is to share considerations around requiring subjects to
respond to items and provide data on the prevalence of skipped items in three
therapeutic areas and ePRO modes.? Methods: Three quantitative pilot studies conducted by the PRO Consortium allowed participants to skip items on the
draft questionnaires, one of three scenarios described by O?Donohoe et al. (2015)
on considerations for requiring completion. Use of an ?active skip? ensured that
participants indicated they were choosing to skip an item, and that it was not
missed accidentally. Data on skipped items were analysed from the Non-Small
Cell Lung Cancer Symptom Assessment Questionnaire (NSCLC-SAQ) on a tablet
device, the Symptoms of Major Depressive Disorder Scale (SMDDS) on a webbased system, and the Asthma Daily Symptom Diary (ADSD) on a handheld
device.? Results: Diverse samples were recruited for the NSCLC-SAQ (N=?152),
SMDDS (Wave 1=?315; Wave 2=?207), and ADSD (N=?219) studies. No items were
skipped on the NSCLC-SAQ, while rates of item-level skipping ranged from 0.09%
to 2% of possible completions on the SMDDS and ADSD, respectively. Missing
data appeared to be at random and did not indicate problems with the items
skipped.? Conclusions: Requiring completion of items may reduce missing data
but can result in questionable data. Careful implementation of skipping rules
and the use of well-designed questionnaires assessing relevant and appropriate
concepts for the context of use may reduce respondents? desire to skip items
when allowed to do so, as evidenced by the low rates of missing item-level data
seen in three PRO Consortium studies.
PHP181
Knowledge And Confidence Of Healthcare Providers Working At
Hospitals About Appropriate Prescribing For Geriatrics
Akkawi ME, Nik Mohamed MH
International Islamic University Malaysia, Kuantan, Malaysia
Objectives: To assess the knowledge of health care providers (HCPs) about inappropriate prescribing (IP) in geriatrics, and their confidence in prescribing for this
population.? Methods: Six clinical vignettes were developed based on 2015 Beers
criteria and the STOPP/START criteria version 2 to assess the knowledge. The confidence was investigated by asking the HCPs about their agreement on the following
statement ?I have confidence in my ability to recommend appropriate medications
for the older patients?. The scale was validated by expert panel, piloted on 34 HCPs
and then distributed to 123 physicians and clinical pharmacists working in general
medical wards of two tertiary hospitals in Malaysia.? Results: The scale content
validity index value of 0.95 and the Cronbach?s Alpha value of 0.717 indicate good
content validity and reliability, respectively. Of the 82 HCPs who completed the
questionnaire, 35% were clinical pharmacists, 9.8% had ever undergone a training in geriatric medicine, and 70.8% stated that about 25% of their patients are
elderly. Only 7.3% had ever used the STOPP/START or Beers criteria when prescribing for older patients, and 60% of the respondents had never heard of either
criteria. The mean (SD) score in knowledge part was 3.65 (1.46) points out of 6 and
only 27 HCPs (22.9%) scored high (?? 5 points). The frequent incorrectly answered
clinical vignette was that pertaining to long-term pain management in patients
with cardiovascular comorbidities. Overall, only 34% of HCPs rated themselves as
confident in prescribing for older patients and this was significantly associated
with their knowledge score (p =? 0.02).? Conclusions: The study showed low
confidence in prescribing for older patients coupled with inadequate knowledge
about IP in more than half of the participants. Educational program regarding
geriatric pharmacotherapy is needed to boost HCP?s knowledge and confidence
in prescribing for older patients.
20 (2017) A399?A811
A683
PHP182
The Effect Of Chronic Diseases, Financial Hardship And Personality
Types In Patient?s Medication Adherence
Ibrahim K1, Schommer JC2, Tieger PD3, Tomaszewski DM4, Brown LM4, Morisky DE5
of Minnesota, Minneapolis, MN, USA, 2University of Minnesota College of Pharmacy,
Minneapolis, MN, USA, 3SpeedReading People, LLC, Hartford, CT, USA, 4Chapman University,
Irvine, CA, USA, 5UCLA School of Public Health, Los Angeles, CA, USA
1University
Objectives: Medication adherence has been shown to be associated with the
nature of the disease being treated and characteristics of the prescribed treatment. Non-adherence typically ranges between 30?50% of all patients. In addition,
patients? beliefs about health and illness and their behavioral expressions of their
personality types may be important contributors to medication adherence. The
objective of this study was to describe the associations between disease type, financial hardship and four personality temperaments (Traditionalists, Experiencers,
Idealists, Conceptualizers) with self-reported medication adherence.? Methods:
Data were collected from the 2015 National Consumer Survey of the Medication
Experience and Pharmacists? Roles, via an on-line, self-administered survey coordinated by Qualtrics Panels in the United State of America, between April 28, 2015,
and June 22, 2015. Data were analyzed using IMB/SPSS version 24.0 software. Logistic
regression analysis and descriptive statistics were used.? Results: Out of 26,173
responses, 12,195 were taking at least one prescription medication and were not
a licensed health professional, making them eligible for this study. Of these, the
highest proportion of non-adherence among those without financial hardship was
shown in breathing problems disease (37%), and least was in cancer (19%). Among
those with financial hardship, non-adherence increased significantly (listed from
the highest increase to lowest) to 41% for cancer, 40% for heart disease, 48% for
diabetes, 45% for arthritis, 50% for obesity, and 44% for stroke. Of the four personality types, Experiencers had the highest rate of non-adherence and Traditionalists
were the lowest in all disease types regardless of financial hardship. Logistic regression models showed that disease type, financial hardship, and personality type all
affected the likelihood of non-adherence.? Conclusions: In addition to acknowledging disease and treatment characteristics, financial hardship and personality
type are important considerations for improving adherence to medications.
PHP183
Why Do People Participate In Health-Related Preference Studies?
A Discrete-Choice Experiment
Bridges JF, Janssen EM
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Objectives: Patient and citizens are increasingly asked to participate in surveys about health to promote community centeredness. Ethical standards govern
how one might interact with respondents, but there is a paucity of research asking what potential respondents want out of this type of research. We sought to
document the preferences and motivations of potential respondents to survey
research.? Methods: Respondents from a national panel completed a discretechoice experiment comparing pairs of potential studies respondents could participate in at a local hospital. Studies were defined across six attributes (validity,
relevance, bias, burden, time, and reimbursement) with three possible levels each. A
D-efficient design resulted in three blocks of 12 tasks. A choice model was estimated
using a continuous coded mixed logit and latent class analysis (LCA). After completing the survey respondents were asked which motivating factors they used to justify
their choices from pre-defined list of factors that were identified through community engagement.? Results: :�9 people participated in the survey. Participants
valued validity (OR=?2.4), relevance (OR=?1.8), and minimizing bias (OR=?1.7) the
most. A 2-class LCA confirmed that the majority of participants (76%) valued quality indicators, but 24% of respondents strongly valued incentives such as increasing
reimbursement (OR=?3.4) or decreasing time (OR=?1.3). While both groups had similar
motivations, the quality-focused class was more likely to be motivated by ?measuring real preference? (p<?0.001) and ?benefits to society? (p=?0.009).? Conclusions:
Given the increase in studies focused on patient and community centeredness, the
paucity of preference-based research focused on what patients and citizens want
out of research is surprising. Understanding the motivations of respondents is not
only important in designing future studies, but also in interpreting the results of
existing studies.
PHP184
Breakfast Consumption And Associated Factors Among Students In
Olabisi Onabanjo University, Ogun State, Nigeria
Ojieabu CE, Sholeye O, Ojieabu W, Onabajo B
Olabisi Onabanjo University, Sagamu, Nigeria
Objectives: This study therefore assessed the pattern of breakfast consumption
in undergraduate students and its associated factors.? Methods: A cross-sectional
study was carried out among 302 students of allied health sciences in Olabisi
Onabanjo University, Sagamu, Ogun State, selected via multi-stage sampling. Data
was collected with the aid of a semi-structured, self-administered questionnaire
and analyzed using SPSS 20.0. Relevant descriptive and inferential statistics were
calculated. Participation was fully voluntary.? Results: The mean age of respondents was 20�years, 73.5% of the participants were females while 26.5% were males.
Only 32.5% of the respondents consumed breakfast on a daily basis while 67.5%
skipped breakfast . About 4% of the total respondents ate breakfast weekly. Majority
(67.9%) of the individuals had a low Individual Dietary Diversity Score (IDDS). There
was a significant relationship between breakfast consumption and academic performance of the students (p=?0.000) as well as breakfast consumption and eating
outside the home (p=?0.004). Out of the breakfast skippers in this study (67.5%)
majo1rity of them skipped breakfast due to time constraints as well as financial
constraints.? Conclusions: Majority of the respondents had no knowledge about
the importance of breakfast consumption. The pattern of breakfast consumption
of the respondents was irregular and was majorly influenced by time constraints,
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