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2004
Ring closure reactions
O 0130
Synthesis of Polyfunctionally Substituted Heteroaromatic Compounds via BenzoChalcones with Antimicrobial and Antifungal Activities. — The unre44- 046 triazolyl
ported benzotriazolyl chalcones (III) and pentadienone derivative (XVI) are utilized as
building blocks for new polyfunctionally substituted heteroaromatic compounds. The
reactivity of the new chalcones (III) and of dienone (XVI) toward carbon and nitrogen
nucleophiles is investigated. Some structural modifications of compound (VII), an isomer of (VIb) which is not obtained from (IIIb), are also carried out. Some compounds
are screened for their antifungal and antibacterial activity. Compounds (VIb), (VIII),
(X), (XII), and (XIV) display strong antibacterial and antifungal activity. —
(AL-OMRAN*, F.; EL-KHAIR, A. A.; J. Heterocycl. Chem. 41 (2004) 3, 327-333;
Dep. Chem., Fac. Sci., Kuwait Univ., Safat 13060, Kuwait; Eng.) —
H. Hoennerscheid
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