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2004
Imidazole derivatives
R 0190
Synthesis of Imidazolidin-4-one and 1H-Imidazo[2,1-a]isoindole-2,5(3H,9bH)-diDerivatives of Primaquine: Scope and Limitations. — Amino acid derivatives
44- 132 one
(I) and (II) undergo cyclization with ketones to give imidazolidinones [cf. (III)—(VII),
20 examples] in good yields. For selected imidazolidinones low rates of hydrolysis in
physiological conditions are measured suggesting that they may be useful as effective
and metabolically stable derivatives of antimalarial agents (I) and (II). — (GOMES*,
P.; ARAUJO, M. J.; RODRIGUES, M.; VALE, N.; AZEVEDO, Z.; ILEY, J.;
CHAMBEL, P.; MORAIS, J.; MOREIRA, R.; Tetrahedron 60 (2004) 26, 5551-5562;
Dep. Quim., Fac. Cienc., Univ. Porto, P-4169 Porto, Port.; Eng.) — Klein
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