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2004
Isoxazole derivatives
R 0240
Synthesis, Antiprotozoal and Cytotoxic Activities of New N-(3,4-Dimethyl-5Derivatives. — 3 Derivatives (III), (IV),
44- 139 -isoxazolyl)-1,2-naphthoquinone-4-amino
and (VI) are prepared as possible prodrugs of (I), a compound which exhibits significant activity against Trypanosoma cruzi and Plasmodium falciparum but shows cytotoxicity against murine L-6 cells. Compounds (III) and (IV) are active against T. cruzi
but are also cytotoxic toward L-6 cells so that they cannot be used as prodrugs of (I).
— (SPERANDEO*, N. R.; BRINON, M. C.; BRUN, R.; Farmaco 59 (2004) 6,
431-435; Dep. Farm., Fac. Cienc. Quim., Univ. Nac. Cordoba, 5016 Cordoba, Argent.;
Eng.) — M. Bohle
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