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2004
Thiadiazole derivatives
R 0300
Potential Protease Inhibitors Based on a Functional Cyclic Sulfamide Scaffold.
Starting from racemic serine methyl ester (I), 19 thiadiazolidin 1,1-dioxides are pre44- 143 —
pared which vary in the amide moiety at the 3-position and the substituents at 5-position
(H, CONHR, SO2R). The inhibitory activity of these compounds against human leukocyte elastase is screened, leading to compounds (VIII) as the most active ones. —
(ZHONG, J.; GAN, X.; ALLISTON, K. R.; LAI, Z.; YU, H.; GROUTAS, C. S.;
WONG, T.; GROUTAS*, W. C.; J. Comb. Chem. 6 (2004) 4, 556-563; Dep. Chem.,
Wichita State Univ., Wichita, KS 67260, USA; Eng.) — Klein
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