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2004
Pyridazine derivatives
R 0500
New Derivatives of Pyrrolo[3,4-d]pyridazinone and Their Anticancer Effects. —
series of 18 new title compounds of type (III), (V) and (VI) are prepared. Some of
44- 173 A
the compounds are tested for their anticancer activity. Compounds (VIc)—(VId) give
the best results. However substantial inhibition of the cell growth is observed only at
concentrations ≥10 -5mole/l. They are not considered for additional testing. —
(MALINKA*, W.; REDZICKA, A.; LOZACH, O.; Farmaco 59 (2004) 6, 457-462;
Dep. Chem. Drugs, Wroclaw Univ. Med., PL-50-137 Wroclaw, Pol.; Eng.) —
M. Bohle
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