close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2004
Cyclohexane derivatives
Q 0040
[4 + 2] Cyclohexane Ring Formation by a Tandem of a Free Radical Alkylation of
a Non-Activated δ-Carbon Atom and Intramolecular Carbanion Cycloalkylation.
45- 078 —
Starting from arenesulfenates as the precursors of alkoxy radicals (four-carbon atom
fragment), free radical δ-alkylation of methyl vinyl ketone (two-carbon fragment) leads
to hydroxy ketones. After conversion into keto tosylates or mesylates, followed by generation of enolate anions, they undergo cycloalkylation to give the desired cyclohexane
derivatives. No cycloalkylation reaction appears in the reaction of the alcohol derived
from (XVII), thus demonstrating the importance of the appropriate stereochemistry at
the reactive centers. Only the epimerized alcohol [cf. (XVIII)] affords the desired cyclized product. — (PETROVIC, G.; CEKOVIC*, Z.; Synthesis 2004, 10, 1671-1679;
Fac. Chem., Univ. Belgrade, YU-11000 Belgrade, Yugoslavia; Eng.) — Klein
2004
Документ
Категория
Без категории
Просмотров
0
Размер файла
37 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа