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2004
Pyridazine derivatives
R 0500
Synthesis and Hypotensive Activity of Some 6-(Substituted aryl)-4-methyl-2,3-di— The title compounds (VI) (20 examples) are synthesized
45- 172 hydropyridazin-3-ones.
by cyclization of readily available β-aroyl-2-methylene propionates (V) with hydrazine
hydrate. The majority of these pyridazinones is found to possess significant hypotensive activity in normotensive rats. — (SIDDIQUI*, A. A.; WANI, S. M.; Indian J.
Chem., Sect. B: Org. Chem. Incl. Med. Chem. 43 (2004) 7, 1574-1579; Dep. Pharm.
Chem., Fac. Pharm., New Delhi 110 062, India; Eng.) — R. Langenstrassen
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