close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2004
Benzopyran derivatives
R 0350
Inhibition of Monoamine Oxidases by Coumarin-3-acyl Derivatives: Biological
and Computational Study. — Coumarincarboxylic esters, acids (V), and
46- 136 Activity
coumarinacyl chlorides (VI) are synthesized and investigated for their ability to inhibit
selectively monoamine oxidases. In the case of acids (V) and chlorides (VI) the coumarin nucleus is more conveniently constructed by the heterocyclization reaction
between hydroxybenzaldoximes (II) and carbon suboxide (III) to achieve multigram
scale results and easy purification. The esters show weak activity against both MAO
isoforms, while acids (V) are more active as inhibitors of MAO-B. Acid (Va) displays
high selectivity towards the MAO-B isoenzyme. Acyl chlorides (VI) exhibit strong
anti-MAO activity against both isoforms, with (VIc) being the most active compound
against MAO-B, but low selectivity behavior. — (CHIMENTI, F.; SECCI*, D.;
BOLASCO, A.; CHIMENTI, P.; GRANESE, A.; BEFANI, O.; TURINI, P.; ALCARO,
S.; ORTUSO, F.; Bioorg. Med. Chem. Lett. 14 (2004) 14, 3697-3703; Dip. Stud.
Chim. Tecnol. Sostanze Biol. Attive, Univ. La Sapienza, I-00185 Roma, Italy; Eng.)
— H. Hoennerscheid
Документ
Категория
Без категории
Просмотров
0
Размер файла
17 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа