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2004
Alkaloids
U 0600
46- 199
A Photochemical Approach to Pyridopyrroloquinoline Derivatives as New Potential Anticancer Agents. — With the object to obtaining some biologically active analogues of the cytotoxic alkaloids cryptolepine and ellipticine, title compounds (VII) are
prepared. Key step of the synthesis is the photocyclization of tertiary enaminones (III).
The angular cyclized compounds thus obtained are subjected to Beckmann rearrangement, preceded by the formation of (Z)-oximes (V). Finally, the γ-lactam ring is oxidized using Pd-C in diphenyl ether. — (ARAGON, P.-J.; YAPI, A.-D.; PINGUET, F.;
CHEZAL, J.-M.; TEULADE, J.-C.; CHAPAT, J.-P.; BLACHE*, Y.; Chem. Pharm.
Bull. 52 (2004) 6, 659-663; Unite Mol. Interet Biol., Lab. Chim. Org. Chim. Ther.,
Fac. Pharm., F-21079 Dijon, Fr.; Eng.) — M. Paetzel
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