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2004
Other bioactive products
U 1300
New Efficient Synthesis of Resorcinylic Macrolides via Ynolides: Establishment
Cycloproparadicicol as Synthetically Feasible Preclinical Anticancer Agent
46- 220 of
Based on Hsp90 as the Target. — Some analogues of cycloproparadiciol (I) are prepared including the first total synthesis of aigialomycin D (II). The products are evaluated for their inhibitory activity against breast cancer with (I) as the most active candidate for further studies. — (YANG, Z.-Q.; GENG, X.; SOLIT, D.; PRATILAS, C. A.;
ROSEN, N.; DANISHEFSKY*, S. J.; J. Am. Chem. Soc. 126 (2004) 25, 7881-7889;
Dep. Chem., Columbia Univ., New York, NY 10027, USA; Eng.) — Klein
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