close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2004
Amino acids
U 0400
Asymmetric Synthesis of Quaternary α- and β-Amino Acids and β-Lactams via
Mannich Reactions with Branched Aldehyde Donors. — It is
47- 172 Proline-Catalyzed
shown for the first time that direct asymmetric Mannich reactions of N-PMP-protected
α-imino ethyl glyoxylate with various α,α-disubstituted aldehydes afford quaternary
β-formyl α-amino acid derivatives with excellent yields and enantioselectivities. The
method is an additional organocatalytic route to synthons containing chiral all-carbon
quaternary centers. Highly efficient and two-step asymmetric syntheses of quaternary
α- and β-amino acids and β-lactams are developed without any racemization. —
(CHOWDARI, N. S.; SURI, J. T.; BARBAS*, C. F. I.; Org. Lett. 6 (2004) 15,
2507-2510; Dep. Chem., Scripps Res. Inst., San Diego, La Jolla, CA 92037, USA;
Eng.) — Steudel
Документ
Категория
Без категории
Просмотров
0
Размер файла
35 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа