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2004
Other bioactive products
U 1300
Antimitotic Activity of Glaupalol-Related Coumarins from Glaucidium palma— The new coumarins (I) and (II) are isolated from the rhizomes of G. palmatum
47- 206 tum.
(Glaucidiaceae) along with five related coumarins. Their absolute configurations are
elucidated by spectroscopic data, chemical derivatization, and exciton chirality method. Some coumarins show moderate cytotoxicity against KB cells. The cytotoxicity of
paclitaxel is synergistically enhanced in addition of glaupalol (III). This compound
shows paclitaxel-like activity to microtubule systems; it promotes the polymerization
of tubulin and reduces the depolymerization process induced by Ca2+ addition. —
(MORITA, H.; DOTA, T.; KOBAYASHI*, J.; Bioorg. Med. Chem. Lett. 14 (2004) 14,
3665-3668; Grad. Sch. Pharm. Sci., Hokkaido Univ., Sapporo 060, Japan; Eng.) —
H. Hoennerscheid
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