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2004
Pyridine derivatives
R 0380
Synthesis of Aminopyridines from 2-Fluoropyridine and Lithium Amides. —
which are not activated by electron-withdrawing substituents react
48- 120 2-Fluoropyridines
sluggishly with primary and secondary amines to give 2-aminopyridines [cf. (III)].
However, the use of lithium amides results in a more efficient nucleophilic substitution
reaction. 2-Chloro- and 3-bromopyridine react with lithium amides to give ring-opened
products (no details given). — (PASUMANSKY, L.; HERNANDEZ, A. R.;
GAMSEY, S.; GORALSKI, C. T.; SINGARAM*, B.; Tetrahedron Lett. 45 (2004) 34,
6417-6420; Dep. Chem. Biochem., Univ. Calif., Santa Cruz, CA 95064, USA; Eng.)
— Mais
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