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2004
Fused pyridine derivatives
R 0450
Synthesis and Structure—Activity Relationships of 1,5-Diazaanthraquinones as
Compounds. — A variety of 1,5-diazaanthraquinones [cf. (III), (VI)] are
49- 134 Antitumor
synthesized employing single or double hetero-Diels—Alder strategies. Their in vitro
antitumor activity is assayed and compared with data obtained for their 1,8-diaza-regioisomers [cf. (IX)]. Some of these 1,5-diazaanthraquinones are very interesting antitumor compounds, particularly for some solid tumors. — (AVENDANO, C.; PEREZ, J.
M.; DEL MAR BLANCO, M.; DE LA FUENTE, J. A.; MANZANARO, S.; VICENT,
M. J.; MARTIN, M. J.; SALVADOR-TORMO, N.; MENENDEZ*, J. C.; Bioorg.
Med. Chem. Lett. 14 (2004) 15, 3929-3932; Dep. Quim. Org. Farm., Fac. Farm., Univ.
Complutense, E-28040 Madrid, Spain; Eng.) — M. Schroeter
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