close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2004
Pyridine derivatives with bridges
R 0460
Double Cyclization of Bis(α-hetarylmethyl)amino Esters to Optically Active
N-Heterocycles of HIV-Inhibiting Activity. — The synthesis of optically
49- 135 Bridged
active anellated azabicyclo[3.3.1]nonanes (IV) and (XI) is readily achieved by halogen/
lithium exchange and subsequent double cyclization of bis(α-hetarylmethyl)amino
esters (III) and (X), resp., which in turn are obtained on various ways from o-bromohetarylmethyl bromides (I) and optically active amino acid esters (II). The cyclization
is influenced by the steric bulk of the reactants and in some cases only the monocyclization products (VI)/(VII) or (XII) are achieved. The double cyclization products
possess interesting inhibiting activity against reverse transcriptase and DNA polymerase of HIV-1. — (FALTZ, H.; BENDER, C.; WOEHRL, B. M.;
VOGEL-BACHMAYR, K.; HUEBSCHER, U.; RAMADAN, K.; LIEBSCHER*, J.;
Eur. J. Org. Chem. 2004, 16, 3484-3496; Inst. Chem., Humboldt-Univ., D-12489
Berlin, Germany; Eng.) — Mischke
2004
Документ
Категория
Без категории
Просмотров
0
Размер файла
42 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа