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2004
Benzopyran derivatives
R 0350
Synthesis of 2-Oxo-2H-chromene-3-carboxylic Acid (5-Methyl-3-isoxazolyl) and
Amides as Potential Bioactive Compounds. —
50- 100 (3-Methyl-5-styryl-4-isoxazolyl)
Title compounds (V) and (VII) are prepared from aminoisoxazoles (I) and (VI) respectively by treatment with diethylmalonate (II) followed by cyclization with salicylaldehydes (IV) (no yields given). (Vb) shows significant antibacterial activity against
Escherichia coli, Proteus vulgaris, Bacillus mycoides and Staphylococcus aureus and
the degree of inhibition is comparable to that of streptomycin. —
(RAJANARENDAR*, E.; RAMU, K.; RAMESH, P.; Indian J. Chem., Sect. B: Org.
Chem. Incl. Med. Chem. 43 (2004) 8, 1790-1793; Dep. Chem., Kakatiya Univ.,
Warangal 506 009, India; Eng.) — H. Haber
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