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2004
Purine derivatives
R 0540
Preparation of New N6,9-Disubstituted 2-Phenyl-adenines and Corresponding
8-Azaadenines. A Feasibility Study for Application to Soid-Phase Synthesis. Part
50- 126 1. — The pyrimidine core of (I) is manipulated to adenines (IX) and (XI) or azaadenines
(XIII) under conditions which are compatible with the possible utilization of a thiomethyl resin for covalent bonding to (I). In this method a phenylmethanesulfanyl group,
at a later stage oxidized to a phenylmethanesulfonyl moiety for detachment, is used as
a model for such a resin. Azaadenines (XIII) are prepared from (XII) in the same fashion as that for the preparation of adenines (IX) and (XI). Sulfones (VIII) show a marked
instability and are immediately converted into the final compounds (IX) and (XI). —
(BIAGI, G.; GIORGI*, I.; LIVI, O.; PACCHINI, F.; SCARTONI, V.; SALERNI, O. L.;
J. Heterocycl. Chem. 41 (2004) 4, 575-580; Dip. Sci. Farm., Univ. Pisa, I-56126 Pisa,
Italy; Eng.) — H. Hoennerscheid
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