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2004
Pyrazine derivatives
R 0550
Antioxidative Activities of Novel Diphenylalkyl Piperazine Derivatives with High
for the Dopamine Transporter. — A new series of diarylalkylpiperazine
50- 129 Affinities
derivatives [cf. (VI), (VII), (XI), (XII)] are synthesized and evaluated for their inhibitory activity against auto-oxidative lipid peroxidation in canine brain homogenates.
The title compounds possess moderate to potent antioxidative activity. The most active
derivative (XII) is 5-fold more potent than α-tocopherol. — (KIMURA*, M.; et al.;
Bioorg. Med. Chem. Lett. 14 (2004) 16, 4287-4290; Pharm. R&D Lab., POLA Chem.
Ind. Inc., Yokohama, Kanagawa 244, Japan; Eng.) — R. Staver
2004
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