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2004
Anticancer activity
X 0070
A Library Synthesis of 4-Hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic
Ethyl Ester Derivatives as Antitumor Agents. — The unoptimized substruc50- 209 Acid
tures of a screening hit from small-molecule libraries is modified by introduction of
substituents on the phenyl ring at C-6 of the benzofuran core. The synthesis of the title
derivatives is achieved by using a technique of solution-phase parallel synthesis. In
addition, sub-structure modification at the ester moiety of the screening hit leads to the
discovery of the highly potent derivatives (I). — (HAYAKAWA, I.; SHIOYA, R.;
AGATSUMA, T.; FURUKAWA, H.; NARUTO, S.; SUGANO*, Y.; Bioorg. Med.
Chem. Lett. 14 (2004) 17, 4383-4387; Lead Discovery Res. Lab., Sankyo Co., Ltd.,
Shinagawa, Tokyo 140, Japan; Eng.) — H. Hoennerscheid
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